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学科主题: 临床医学
题名:
Levels of Phthalate Metabolites in Urine of Pregnant Women and Risk of Clinical Pregnancy Loss
作者: Mu, Di1; Gao, Fumei1; Fan, Zhanlan1; Shen, Huan2; Peng, Hui1; Hu, Jianying1
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2015-09-01
DOI: 10.1021/acs.est.5b02617
卷: 49, 期:17, 页:10651-10657
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Environmental ; Environmental Sciences
研究领域[WOS]: Engineering ; Environmental Sciences & Ecology
关键词[WOS]: N-BUTYL PHTHALATE ; BODY-MASS INDEX ; BISPHENOL-A ; DI(2-ETHYLHEXYL) PHTHALATE ; DEVELOPMENTAL TOXICITY ; DIISOBUTYL PHTHALATE ; SPONTANEOUS-ABORTION ; WAIST CIRCUMFERENCE ; GENERAL-POPULATION ; PROSPECTIVE COHORT
英文摘要:

Toxicological studies have shown that phthalate esters (PAEs), a class of widely used and environmentally prevalent chemicals, can increase the abortion rate in animals, but epidemiological evidence is scarce. This study aimed to explore the relationship between the urinary concentration of phthalate metabolites and the risk of clinical pregnancy loss. A total of 132 women who underwent clinical pregnancy loss (cases) and 172 healthy pregnant women (controls) were recruited from Beijing, China. Eight phthalate metabolites in urine were determined by ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Five phthalate metabolites, monomethyl phthalate (MMP), monoethyl phthalate (MEP), mono-isobutyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), and mono (2-ethlyhexyl) phthalate (MEHP), were detected in at least 95% of the urine samples, with the highest median concentration of 51.0 mu g/g of creatinine for MnBP of all participants. The differences in urinary concentrations of phthalate metabolites between cases and controls were evaluated using the Mann-Whitney U test. The concentrations of MEP (median of 18.7 mu g/g of creatinine), MiBP (23.3 mu g/g of creatinine), and MnBP (58.2 mu g/g of creatinine) detected in the cases were significantly higher than those (15.7 mu g/g of creatinine for MEP, 19.4 mu g/g of creatinine for MiBP, and 43.9 mu g/g of creatinine for MnBP) in the controls (p < 0.05). Increasing risks of clinical pregnancy loss were observed from the first to fourth quartiles of the MEP, MiBP, and MnBP concentrations (p < 0.05 for trend). We concluded that exposure to MEP, MiBP, and MnBP was associated with an increased risk of clinical pregnancy loss.

语种: 英语
所属项目编号: 21577001 ; 21507003 ; 7112141
项目资助者: National Natural Science Foundation of China ; Beijing National Science Foundation
WOS记录号: WOS:000360773600045
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51003
Appears in Collections:北京大学第二临床医学院_计划生育与生殖医学科_期刊论文

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作者单位: 1.Peking Univ, Coll Urban & Environm Sci, Lab Earth Surface Proc, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Mu, Di,Gao, Fumei,Fan, Zhanlan,et al. Levels of Phthalate Metabolites in Urine of Pregnant Women and Risk of Clinical Pregnancy Loss[J]. ENVIRONMENTAL SCIENCE &amp; TECHNOLOGY,2015,49(17):10651-10657.
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