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Identification of a gene associated with astragalus and angelica′s renal protective effects by silver staining mRNA differential display
Yu, L; Lu, YY; Li, JZ; Wang, HY
关键词Kidney Fibrosis Gene Expression Astragalus Angelica
刊名CHINESE MEDICAL JOURNAL
2002-06-01
115期:6页:923-927
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]MESSENGER-RNA ; KIDNEY
英文摘要

Objective To identify genes associated with the chronic progression of renal disease and astragalus and angelica (A&A) ′ s renal protective effects.

Methods The technique of silver staining mRNA differential display (DD) was used to investigate changes of gene expression in normal, sclerotic and A&A treated sclerotic kidneys. We isolated genes differentially expressed during the progression of renal disease which could be normalized by A&A.

Results Several genes related to A&A′ s protective effects were isolated and one of them was confirmed by Northern blot.

Conclusion Silver staining mRNA differential display is a simple and effective technique for isolating differentially expressed genes. The isolated new gene may be related to the progression of chronic renal disease and contribute to A&A′s protective effects.

语种英语
WOS记录号WOS:000176693300028
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51005
专题北京大学第一临床医学院_肾脏内科
北京大学公共卫生学院_流行病与卫生统计学系
北京大学第一临床医学院_药剂科
北京大学精神卫生研究所_护理部
作者单位Peking Univ, Teaching Hosp 1, Dept Nephrol, Inst Nephrol, Beijing 100034, Peoples R China
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GB/T 7714
Yu, L,Lu, YY,Li, JZ,et al. Identification of a gene associated with astragalus and angelica′s renal protective effects by silver staining mRNA differential display[J]. CHINESE MEDICAL JOURNAL,2002,115(6):923-927.
APA Yu, L,Lu, YY,Li, JZ,&Wang, HY.(2002).Identification of a gene associated with astragalus and angelica′s renal protective effects by silver staining mRNA differential display.CHINESE MEDICAL JOURNAL,115(6),923-927.
MLA Yu, L,et al."Identification of a gene associated with astragalus and angelica′s renal protective effects by silver staining mRNA differential display".CHINESE MEDICAL JOURNAL 115.6(2002):923-927.
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