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学科主题: 临床医学
题名:
Improved outcomes using G-CSF-mobilized blood and bone marrow grafts as the source of stem cells compared with G-PB after HLA-identical sibling transplantation in patients with acute leukemia
作者: Zhao, Xiao-su1; Chen, Yao1; Zhao, Xiang-yu1; Liu, Dai-hong1; Xu, Lan-ping1; Wang, Yu1; Han, Wei1; Chen, Yu-hong1; Chen, Huan1; Zhang, Xiao-hui1; Liu, Kai-yan1; Huang, Xiao-jun1,2
关键词: acute leukemia ; allogeneic hematopoietic stem cell transplantation ; graft ; HLA identical ; graft ; outcome
刊名: CLINICAL TRANSPLANTATION
发表日期: 2013-11-01
DOI: 10.1111/ctr.12225
卷: 27, 期:6, 页:844-851
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery ; Transplantation
研究领域[WOS]: Surgery ; Transplantation
关键词[WOS]: COLONY-STIMULATING FACTOR ; VERSUS-HOST-DISEASE ; UNMANIPULATED HAPLOIDENTICAL BLOOD ; SEVERE APLASTIC-ANEMIA ; HEMATOLOGIC MALIGNANCIES ; PLATELET ENGRAFTMENT ; PEDIATRIC-PATIENTS ; CLINICAL-OUTCOMES ; IMPACT ; CD34(+)
英文摘要:

This retrospective study compared the transplantation outcomes of 98 consecutive patients with acute leukemia. Allogeneic hematopoietic stem cell transplantation was performed using G-CSF-mobilized bone marrow and blood (G-BM&PB) or G-CSF-mobilized peripheral blood (G-PB) from HLA-identical sibling donors. The G-BM&PB and G-PB groups displayed significantly different neutrophil recovery rates (medians of 15 vs. 14d, respectively; p=0.009) but similar platelet recovery rates. The cumulative incidences of grades II-IV acute graft-versus-host disease (aGVHD) in the G-BM&PB and G-PB cohorts were similar (16.2 +/- 4.7% vs. 21.8 +/- 7.4%, respectively; p=0.676), but the incidences of grades III-IV aGVHD were significantly different (5.5 +/- 3.1% vs. 18.9 +/- 7.1%, respectively; p=0.042). The G-BM&PB and G-PB cohorts displayed similar cumulative incidences of chronic GVHD (cGVHD, 49.1 +/- 5.7% vs. 42.7 +/- 6.8%, respectively; p=0.465), one-yr cumulative incidences of treatment-related mortality (16.5 +/- 3.5% vs. 24.4 +/- 4.1%, respectively; p=0.220), and five-yr cumulative incidences of relapse (13.9 +/- 4.8% vs. 26.8 +/- 7.2%, respectively; p=0.113). The five-yr probability of leukemia-free survival (LFS) was significantly higher in the G-BM&PB group than in the G-PB group (77.8 +/- 5.2% vs. 57.6 +/- 8.6%, respectively; p=0.023). Multivariate analysis identified G-PB as an independent risk factor for grades III-IV aGVHD and LFS. Our results suggest that HLA-identical transplantation with G-BM&PB results in superior clinical outcomes compared with G-PB for patients with acute leukemia.

语种: 英语
所属项目编号: 81230013 ; 2011-4022-08
项目资助者: Key Program of National Natural Science Foundation of China ; Ministry of Health of China ; Scientific Research Foundation for Capital Medicine Development ; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation
WOS记录号: WOS:000327765500024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51006
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Xiao-su,Chen, Yao,Zhao, Xiang-yu,et al. Improved outcomes using G-CSF-mobilized blood and bone marrow grafts as the source of stem cells compared with G-PB after HLA-identical sibling transplantation in patients with acute leukemia[J]. CLINICAL TRANSPLANTATION,2013,27(6):844-851.
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