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Improved outcomes using G-CSF-mobilized blood and bone marrow grafts as the source of stem cells compared with G-PB after HLA-identical sibling transplantation in patients with acute leukemia
Zhao, Xiao-su1; Chen, Yao1; Zhao, Xiang-yu1; Liu, Dai-hong1; Xu, Lan-ping1; Wang, Yu1; Han, Wei1; Chen, Yu-hong1; Chen, Huan1; Zhang, Xiao-hui1; Liu, Kai-yan1; Huang, Xiao-jun1,2
关键词Acute Leukemia Allogeneic Hematopoietic Stem Cell Transplantation Graft Hla Identical Graft Outcome
刊名CLINICAL TRANSPLANTATION
2013-11-01
DOI10.1111/ctr.12225
27期:6页:844-851
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Transplantation
资助者Key Program of National Natural Science Foundation of China ; Ministry of Health of China ; Scientific Research Foundation for Capital Medicine Development ; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation ; Key Program of National Natural Science Foundation of China ; Ministry of Health of China ; Scientific Research Foundation for Capital Medicine Development ; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation
研究领域[WOS]Surgery ; Transplantation
关键词[WOS]COLONY-STIMULATING FACTOR ; VERSUS-HOST-DISEASE ; UNMANIPULATED HAPLOIDENTICAL BLOOD ; SEVERE APLASTIC-ANEMIA ; HEMATOLOGIC MALIGNANCIES ; PLATELET ENGRAFTMENT ; PEDIATRIC-PATIENTS ; CLINICAL-OUTCOMES ; IMPACT ; CD34(+)
英文摘要

This retrospective study compared the transplantation outcomes of 98 consecutive patients with acute leukemia. Allogeneic hematopoietic stem cell transplantation was performed using G-CSF-mobilized bone marrow and blood (G-BM&PB) or G-CSF-mobilized peripheral blood (G-PB) from HLA-identical sibling donors. The G-BM&PB and G-PB groups displayed significantly different neutrophil recovery rates (medians of 15 vs. 14d, respectively; p=0.009) but similar platelet recovery rates. The cumulative incidences of grades II-IV acute graft-versus-host disease (aGVHD) in the G-BM&PB and G-PB cohorts were similar (16.2 +/- 4.7% vs. 21.8 +/- 7.4%, respectively; p=0.676), but the incidences of grades III-IV aGVHD were significantly different (5.5 +/- 3.1% vs. 18.9 +/- 7.1%, respectively; p=0.042). The G-BM&PB and G-PB cohorts displayed similar cumulative incidences of chronic GVHD (cGVHD, 49.1 +/- 5.7% vs. 42.7 +/- 6.8%, respectively; p=0.465), one-yr cumulative incidences of treatment-related mortality (16.5 +/- 3.5% vs. 24.4 +/- 4.1%, respectively; p=0.220), and five-yr cumulative incidences of relapse (13.9 +/- 4.8% vs. 26.8 +/- 7.2%, respectively; p=0.113). The five-yr probability of leukemia-free survival (LFS) was significantly higher in the G-BM&PB group than in the G-PB group (77.8 +/- 5.2% vs. 57.6 +/- 8.6%, respectively; p=0.023). Multivariate analysis identified G-PB as an independent risk factor for grades III-IV aGVHD and LFS. Our results suggest that HLA-identical transplantation with G-BM&PB results in superior clinical outcomes compared with G-PB for patients with acute leukemia.

语种英语
所属项目编号81230013 ; 2011-4022-08
资助者Key Program of National Natural Science Foundation of China ; Ministry of Health of China ; Scientific Research Foundation for Capital Medicine Development ; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation ; Key Program of National Natural Science Foundation of China ; Ministry of Health of China ; Scientific Research Foundation for Capital Medicine Development ; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation
WOS记录号WOS:000327765500024
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51006
专题北京大学第二临床医学院_血液科
作者单位1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xiao-su,Chen, Yao,Zhao, Xiang-yu,et al. Improved outcomes using G-CSF-mobilized blood and bone marrow grafts as the source of stem cells compared with G-PB after HLA-identical sibling transplantation in patients with acute leukemia[J]. CLINICAL TRANSPLANTATION,2013,27(6):844-851.
APA Zhao, Xiao-su.,Chen, Yao.,Zhao, Xiang-yu.,Liu, Dai-hong.,Xu, Lan-ping.,...&Huang, Xiao-jun.(2013).Improved outcomes using G-CSF-mobilized blood and bone marrow grafts as the source of stem cells compared with G-PB after HLA-identical sibling transplantation in patients with acute leukemia.CLINICAL TRANSPLANTATION,27(6),844-851.
MLA Zhao, Xiao-su,et al."Improved outcomes using G-CSF-mobilized blood and bone marrow grafts as the source of stem cells compared with G-PB after HLA-identical sibling transplantation in patients with acute leukemia".CLINICAL TRANSPLANTATION 27.6(2013):844-851.
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