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学科主题: 临床医学
题名:
Angiotensin-converting enzyme inhibitor usage in patients with incidental atherosclerotic renal artery stenosis
作者: Yang, JG1; Hu, DY1; Li, TC1; Peng, JJ1; Yu, H1; Pang, WY1; Wang, CH1; Xiao, J1; Xu, Y1
关键词: renovascular disease ; angiotensin-converting enzyme inhibitor ; cardiac catheterization
刊名: HYPERTENSION RESEARCH
发表日期: 2004-05-01
卷: 27, 期:5, 页:339-344
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: HIGH BLOOD-PRESSURE ; RENOVASCULAR DISEASE ; CARDIAC-CATHETERIZATION ; VASCULAR-DISEASE ; DYSFUNCTION ; PREVALENCE ; FAILURE ; INSUFFICIENCY ; HYPERTENSION ; NEPHROPATHY
英文摘要:

The efficacy of angiotensin converting enzyme (ACE) inhibitors in treatment of renovascular disease has been controversial. It has been reported that patients with incidental atherosclerotic renal artery stenosis (ARAS) are sometimes treated with ACE inhibitors before being considered for renal revascularization. This study was designed to describe the frequency and the characteristics of patients with incidental ARAS, and to examine the frequency of ACE inhibitor usage in such patients. We studied a cohort of consecutive patients undergoing abdominal aortography at the time of cardiac catheterization. Patients were stratified and compared based on the presence and severity of ARAS. ARAS (greater than or equal to50%) was present in 146 (17.0%) of 859 evaluable patients. Factors independently related to the presence of ARAS were age (odds ratio (OR)=1.07, p<0.001), severity of coronary artery disease (OR=2.13, p<0.001) and peripheral vascular disease (OR=1.79, p=0.021). Among all patients with ARAS, the percentage of ACE inhibitor usage was 74.7% (109/146). Among patients with severe ARAS, moderate ARAS, mild ARAS, insignificant ARAS and normal renal arteries, the percentage of ACE inhibitor usage was 85.7% (95% confidence interval (Cl): 69-100%), 82.9% (95% Cl: 71-95%), 68.5% (95% Cl: 59-78%), 68.6% (95% Cl: 55-82%) and 53.9% (95% Cl: 50-58%), respectively (contingency coefficient=0.17, p<0.001). In patients with severe ARAS, ACE inhibitor use, calcium channel blocker use and diuretic use were shown to correlate significantly with serum creatinine levels after controlling for potential confounding factors. In this study, ACE inhibitors were used commonly in patients with incidental ARAS; the frequency of ACE inhibitor use correlated with the severity of ARAS.

语种: 英语
WOS记录号: WOS:000221850800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51010
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Capital Univ Med Sci, Beijing Tongren Hosp, Ctr Cardiovasc, Beijing 100730, Peoples R China
2.Peking Univ, Peoples Hosp, Hlth Sci Ctr, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Yang, JG,Hu, DY,Li, TC,et al. Angiotensin-converting enzyme inhibitor usage in patients with incidental atherosclerotic renal artery stenosis[J]. HYPERTENSION RESEARCH,2004,27(5):339-344.
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