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学科主题: 药学
题名:
Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: Preparation, characterization, and in vivo evaluation
作者: Chen, Xingwei1; Li, Xinru1; Zhou, Yanxia1; Wang, Xiaoning1; Zhang, Yanhui1; Fan, Yating1; Huang, Yanqing2; Liu, Yan1
关键词: Chitosan ; glucose phosphate ; thermosensitive hydrogel ; ocular irritation ; cornea penetration ; allergic conjunctivitis
刊名: JOURNAL OF BIOMATERIALS APPLICATIONS
发表日期: 2012-11-01
DOI: 10.1177/0885328211406563
卷: 27, 期:4, 页:391-402
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: ALLERGIC CONJUNCTIVITIS ; RHEOLOGICAL EVALUATION ; PHOSPHATE SOLUTIONS ; SUSTAINED DELIVERY ; OPHTHALMIC USE ; ANIMAL-MODELS ; GEL ; PILOCARPINE ; GELATION ; SITU
英文摘要:

The purpose of this study was to evaluate the feasibility of in situ thermosensitive hydrogel based on chitosan in combination with disodium alpha-d-Glucose 1-phosphate (DGP) for ocular drug delivery system. Aqueous solution of chitosan/DGP underwent sol-gel transition as temperature increased which was flowing sol at room temperature and then turned into non-flowing hydrogel at physiological temperature. The properties of gels were characterized regarding gelation time, gelation temperature, and morphology. The sol-to-gel phase transition behaviors were affected by the concentrations of chitosan, DGP and the model drug levocetirizine dihydrochloride (LD). The developed hydrogel presented a characteristic of a rapid release at the initial period followed by a sustained release and remarkably enhanced the cornea penetration of LD. The results of ocular irritation demonstrated the excellent ocular tolerance of the hydrogel. The ocular residence time for the hydrogel was significantly prolonged compared with eye drops. The drug-loaded hydrogel produced more effective anti-allergic conjunctivitis effects compared with LD aqueous solution. These results showed that the chitosan/DGP thermosensitive hydrogel could be used as an ideal ocular drug delivery system in terms of the suitable sol-gel transition temperature, mild pH environment in the hydrogel as well as the organic solvent free.

语种: 英语
所属项目编号: 2009zx09310-001
项目资助者: National Development of Significant New Drugs (New Preparation and New Technology)
WOS记录号: WOS:000310332000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51013
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Pharmaceut Teaching Expt Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Xingwei,Li, Xinru,Zhou, Yanxia,et al. Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: Preparation, characterization, and in vivo evaluation[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2012,27(4):391-402.
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