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Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: Preparation, characterization, and in vivo evaluation
Chen, Xingwei1; Li, Xinru1; Zhou, Yanxia1; Wang, Xiaoning1; Zhang, Yanhui1; Fan, Yating1; Huang, Yanqing2; Liu, Yan1
关键词Chitosan Glucose Phosphate Thermosensitive Hydrogel Ocular Irritation Cornea Penetration Allergic Conjunctivitis
刊名JOURNAL OF BIOMATERIALS APPLICATIONS
2012-11-01
DOI10.1177/0885328211406563
27期:4页:391-402
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
资助者National Development of Significant New Drugs (New Preparation and New Technology) ; National Development of Significant New Drugs (New Preparation and New Technology)
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]ALLERGIC CONJUNCTIVITIS ; RHEOLOGICAL EVALUATION ; PHOSPHATE SOLUTIONS ; SUSTAINED DELIVERY ; OPHTHALMIC USE ; ANIMAL-MODELS ; GEL ; PILOCARPINE ; GELATION ; SITU
英文摘要

The purpose of this study was to evaluate the feasibility of in situ thermosensitive hydrogel based on chitosan in combination with disodium alpha-d-Glucose 1-phosphate (DGP) for ocular drug delivery system. Aqueous solution of chitosan/DGP underwent sol-gel transition as temperature increased which was flowing sol at room temperature and then turned into non-flowing hydrogel at physiological temperature. The properties of gels were characterized regarding gelation time, gelation temperature, and morphology. The sol-to-gel phase transition behaviors were affected by the concentrations of chitosan, DGP and the model drug levocetirizine dihydrochloride (LD). The developed hydrogel presented a characteristic of a rapid release at the initial period followed by a sustained release and remarkably enhanced the cornea penetration of LD. The results of ocular irritation demonstrated the excellent ocular tolerance of the hydrogel. The ocular residence time for the hydrogel was significantly prolonged compared with eye drops. The drug-loaded hydrogel produced more effective anti-allergic conjunctivitis effects compared with LD aqueous solution. These results showed that the chitosan/DGP thermosensitive hydrogel could be used as an ideal ocular drug delivery system in terms of the suitable sol-gel transition temperature, mild pH environment in the hydrogel as well as the organic solvent free.

语种英语
所属项目编号2009zx09310-001
资助者National Development of Significant New Drugs (New Preparation and New Technology) ; National Development of Significant New Drugs (New Preparation and New Technology)
WOS记录号WOS:000310332000002
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51013
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Pharmaceut Teaching Expt Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Xingwei,Li, Xinru,Zhou, Yanxia,et al. Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: Preparation, characterization, and in vivo evaluation[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2012,27(4):391-402.
APA Chen, Xingwei.,Li, Xinru.,Zhou, Yanxia.,Wang, Xiaoning.,Zhang, Yanhui.,...&Liu, Yan.(2012).Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: Preparation, characterization, and in vivo evaluation.JOURNAL OF BIOMATERIALS APPLICATIONS,27(4),391-402.
MLA Chen, Xingwei,et al."Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: Preparation, characterization, and in vivo evaluation".JOURNAL OF BIOMATERIALS APPLICATIONS 27.4(2012):391-402.
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