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Modifications of aminogocoside antibiotics targeting RNA
Zhou, Jian; Wang, Guannan; Zhang, Li-He; Ye, Xiu-Shan
关键词Targeting Rna Aminoglycoside Structure Activity Relationship Drug Discovery Review
刊名MEDICINAL RESEARCH REVIEWS
2007-05-01
DOI10.1002/med.20085
27期:3页:279-316
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]HUMAN-IMMUNODEFICIENCY-VIRUS ; RIBOSOMAL DECODING SITE ; ANTHRAX LETHAL FACTOR ; HIV-1 TAR RNA ; SURFACE-PLASMON RESONANCE ; REV RESPONSIVE ELEMENT ; SMALL-MOLECULE DRUGS ; AMINOGLYCOSIDE ANTIBIOTICS ; CRYSTAL-STRUCTURE ; NEOMYCIN-B
英文摘要

The increased awareness of the central role of RNA has led to realization that RNA, as structural and functional information accumulation, is also drug target to small molecular therapy. Aminoglycosides are a group of well-known antibiotics, which function through binding to specific sites in prokaryotic ribosomal RNA (rRNA) and affecting the fidelity of protein synthesis. Unfortunately, their clinical practice has been curtailed by toxicity and rapid increasing number of resistant strains. Therefore, it is highly desirable to design new modified aminoglycosides that will overcome the undesirable properties of natural occurring aminoglycosides. On the other hand, aminoglycosides as potential antiviral (HIV) agents were also reported. Herein, we survey the current efforts to develop new aminoglycoside derivatives with modification and reconstruction on each sugar ring and review the latest advances in structure-activity relationships (SAR). (c) 2006 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000246000000001
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51021
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Zhou, Jian,Wang, Guannan,Zhang, Li-He,et al. Modifications of aminogocoside antibiotics targeting RNA[J]. MEDICINAL RESEARCH REVIEWS,2007,27(3):279-316.
APA Zhou, Jian,Wang, Guannan,Zhang, Li-He,&Ye, Xiu-Shan.(2007).Modifications of aminogocoside antibiotics targeting RNA.MEDICINAL RESEARCH REVIEWS,27(3),279-316.
MLA Zhou, Jian,et al."Modifications of aminogocoside antibiotics targeting RNA".MEDICINAL RESEARCH REVIEWS 27.3(2007):279-316.
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