北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese
作者: Yang Jiyun2,3,4,5; Li Guisen1,2; Zhu Li6,7,8; Shi Yi2,3,4,5; Lv Jicheng6,7,8; Lu Fang2,3,4,5; Liu Xiaoqi2,3,4,5; Ma Shi2,3,4,5; Jing Cheng2,3,4,5; Lin Ying2,3,4,5; Wang Haiyan6,7,8; Wang Li1,2; Zhang Hong6,7,8; Yang Zhenglin2,3,4,5
关键词: IgA nephropathy ; HLA-DRB1 ; Association study
刊名: BMC MEDICAL GENETICS
发表日期: 2012-05-14
DOI: 10.1186/1471-2350-13-33
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: IMMUNOGLOBULIN-A NEPHROPATHY ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; MAJOR HISTOCOMPATIBILITY COMPLEX ; JAPANESE PATIENTS ; RECEPTOR GENE ; SUSCEPTIBILITY ; HLA ; PROGRESSION ; POPULATION ; ANTIGEN
英文摘要:

Background: Immunoglobulin A nephropathy (IgAN), an immune-complex-mediated glomerulonephritis defined immunohistologically by the presence of glomerular IgA deposits, is the most common primary glomerular disease worldwide and a significant cause of end-stage renal disease. Familial clustering of patients with IgAN suggests a genetic predisposition.

Methods: In this study, 192 patients with IgAN and 192 normal controls in the Sichuan cohort and 935 patients with IgAN and 2,103 normal controls in the Beijing cohort were investigated. HLA-DRB1*01-DRB1*10 specificities were genotyped by the PCR-SSP technique in both cohorts. Based on the HLA-DRB1*04-positive results, the subtypes of HLA-DRB1*04 were analyzed using sequencing-based typing (SBT) in 291 IgAN cases and 420 matched controls.

Results: The frequency of HLA-DRB1*04 in the IgAN group was significantly higher than that in the control group (0.129 vs. 0.092, P = 8.29 x 10(-5), odds ratio (OR) = 1.381, 95% confidence interval (CI) 1.178-1.619). Other alleles at the HLA-DRB1 locus were observed with no significant differences between the case and control groups. The dominant alleles of the HLA-DRB1*04 subtypes were DRB1*0405 in both cohorts. The frequencies of HLA-DRB1*0405 and 0403 were significantly increased in the patients compared to healthy subjects.

Conclusion: HLA-DRB1*04 was significantly associated with primary IgAN in Chinese population. This result implies that HLA-DRB1 gene plays a major role in primary IgAN.

语种: 英语
所属项目编号: 04JY029-045 ; 05ZQ026-018 ; 09ZQ026-034
项目资助者: Department of Science and Technology of Sichuan Province ; Sichuan Academy of Medical Sciences &amp ; Sichuan Provincial People&prime ; s Hospital ; Sichuan Province Science and Technology Foundation for Youth
WOS记录号: WOS:000307079300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51026
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Sichuan Acad Med Sci, Div Renal, Chengdu, Peoples R China
2.Sichuan Prov Peoples Hosp, Chengdu 617002, Sichuan, Peoples R China
3.Sichuan Acad Med Sci, Ctr Human Mol Biol & Genet, Chengdu 617002, Sichuan, Peoples R China
4.Sichuan Acad Med Sci, Key Lab Human Dis Gene Study Sichuan Prov, Chengdu 617002, Sichuan, Peoples R China
5.Inst Lab Med, Chengdu, Peoples R China
6.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
7.Peking Univ, Div Renal, Hosp 1, Beijing 100871, Peoples R China
8.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China

Recommended Citation:
Yang Jiyun,Li Guisen,Zhu Li,et al. The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese[J]. BMC MEDICAL GENETICS,2012,13.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang Jiyun]'s Articles
[Li Guisen]'s Articles
[Zhu Li]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang Jiyun]‘s Articles
[Li Guisen]‘s Articles
[Zhu Li]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace