|The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese|
|Yang Jiyun2,3,4,5; Li Guisen1,2; Zhu Li6,7,8; Shi Yi2,3,4,5; Lv Jicheng6,7,8; Lu Fang2,3,4,5; Liu Xiaoqi2,3,4,5; Ma Shi2,3,4,5; Jing Cheng2,3,4,5; Lin Ying2,3,4,5; Wang Haiyan6,7,8; Wang Li1,2; Zhang Hong6,7,8; Yang Zhenglin2,3,4,5|
|关键词||Iga Nephropathy Hla-drb1 Association Study|
|刊名||BMC MEDICAL GENETICS|
|WOS标题词||Science & Technology|
|类目[WOS]||Genetics & Heredity|
|研究领域[WOS]||Genetics & Heredity|
|关键词[WOS]||IMMUNOGLOBULIN-A NEPHROPATHY ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; MAJOR HISTOCOMPATIBILITY COMPLEX ; JAPANESE PATIENTS ; RECEPTOR GENE ; SUSCEPTIBILITY ; HLA ; PROGRESSION ; POPULATION ; ANTIGEN|
Background: Immunoglobulin A nephropathy (IgAN), an immune-complex-mediated glomerulonephritis defined immunohistologically by the presence of glomerular IgA deposits, is the most common primary glomerular disease worldwide and a significant cause of end-stage renal disease. Familial clustering of patients with IgAN suggests a genetic predisposition.
Methods: In this study, 192 patients with IgAN and 192 normal controls in the Sichuan cohort and 935 patients with IgAN and 2,103 normal controls in the Beijing cohort were investigated. HLA-DRB1*01-DRB1*10 specificities were genotyped by the PCR-SSP technique in both cohorts. Based on the HLA-DRB1*04-positive results, the subtypes of HLA-DRB1*04 were analyzed using sequencing-based typing (SBT) in 291 IgAN cases and 420 matched controls.
Results: The frequency of HLA-DRB1*04 in the IgAN group was significantly higher than that in the control group (0.129 vs. 0.092, P = 8.29 x 10(-5), odds ratio (OR) = 1.381, 95% confidence interval (CI) 1.178-1.619). Other alleles at the HLA-DRB1 locus were observed with no significant differences between the case and control groups. The dominant alleles of the HLA-DRB1*04 subtypes were DRB1*0405 in both cohorts. The frequencies of HLA-DRB1*0405 and 0403 were significantly increased in the patients compared to healthy subjects.
Conclusion: HLA-DRB1*04 was significantly associated with primary IgAN in Chinese population. This result implies that HLA-DRB1 gene plays a major role in primary IgAN.
|项目编号||04JY029-045 ; 05ZQ026-018 ; 09ZQ026-034|
|资助机构||Department of Science and Technology of Sichuan Province ; Sichuan Academy of Medical Sciences & ; Sichuan Provincial People&prime ; s Hospital ; Sichuan Province Science and Technology Foundation for Youth|
|作者单位||1.Sichuan Acad Med Sci, Div Renal, Chengdu, Peoples R China|
2.Sichuan Prov Peoples Hosp, Chengdu 617002, Sichuan, Peoples R China
3.Sichuan Acad Med Sci, Ctr Human Mol Biol & Genet, Chengdu 617002, Sichuan, Peoples R China
4.Sichuan Acad Med Sci, Key Lab Human Dis Gene Study Sichuan Prov, Chengdu 617002, Sichuan, Peoples R China
5.Inst Lab Med, Chengdu, Peoples R China
6.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
7.Peking Univ, Div Renal, Hosp 1, Beijing 100871, Peoples R China
8.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
|Yang Jiyun,Li Guisen,Zhu Li,et al. The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese[J]. BMC MEDICAL GENETICS,2012,13.|
|APA||Yang Jiyun.,Li Guisen.,Zhu Li.,Shi Yi.,Lv Jicheng.,...&Yang Zhenglin.(2012).The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese.BMC MEDICAL GENETICS,13.|
|MLA||Yang Jiyun,et al."The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese".BMC MEDICAL GENETICS 13(2012).|