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学科主题临床医学
Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells
Liu, Zhenhua; Xiao, Yunbei; Yuan, Yeqing; Zhang, Xiaowei; Qin, Caipeng; Xie, Jing; Hao, Yichang; Xu, Tao; Wang, Xiaofeng
关键词Oleic Acid Renal Cell Carcinoma Cell Proliferation Integrin-linked Kinase
刊名ONCOLOGY LETTERS
2013-04-01
DOI10.3892/ol.2013.1160
5期:4页:1395-1399
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]BREAST-CANCER CELLS ; COUPLED RECEPTOR GPR40 ; FATTY-ACIDS ; THERAPEUTIC TARGET ; PROSTATE-CANCER ; PROTEIN ; PROGRESSION ; STRATEGIES ; OBESITY ; RISK
英文摘要

An increased risk of renal cell carcinoma (RCC) has been linked with obesity and metabolic syndrome. However, the mechanisms by which lipid metabolic disorders affect the development of RCC remain unclear and highly controversial. Integrin-linked kinase (ILK) is a serine/threonine protein kinase involved in the regulation of tumor cell growth and angiogenesis. In the present study, the effect of free fatty acids in the promotion of RCC progression was investigated by upregulating ILK. Results of the MTT assay indicated that treatment of 786-O cells with oleic acid induced a concentration-dependent increase in cell viability. Flow cytometry analysis revealed that the effect of oleic acid on cell apoptosis was not significant. Following treatment with oleic acid, the expression of ILK, phospho-Akt and G protein-coupled receptor 40 (GPR40) was increased in 786-O cells. These effects were reversed when the expression of ILK was downregulated using specific small interfering RNA. These results indicate that free fatty acids are associated with the development of renal cell carcinoma via activation of the GPR40/ILK/Akt pathway, revealing a novel mechanism for the correlation between metabolic disturbance and renal carcinoma.

语种英语
WOS记录号WOS:000321003100057
项目编号31171341
资助机构National Natural Science Foundation of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51031
专题北京大学第二临床医学院_泌尿外科
北京大学第三临床医学院_泌尿外科
作者单位Peking Univ, Dept Urol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Liu, Zhenhua,Xiao, Yunbei,Yuan, Yeqing,et al. Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells[J]. ONCOLOGY LETTERS,2013,5(4):1395-1399.
APA Liu, Zhenhua.,Xiao, Yunbei.,Yuan, Yeqing.,Zhang, Xiaowei.,Qin, Caipeng.,...&Wang, Xiaofeng.(2013).Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells.ONCOLOGY LETTERS,5(4),1395-1399.
MLA Liu, Zhenhua,et al."Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells".ONCOLOGY LETTERS 5.4(2013):1395-1399.
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