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学科主题: 临床医学
题名:
Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells
作者: Liu, Zhenhua; Xiao, Yunbei; Yuan, Yeqing; Zhang, Xiaowei; Qin, Caipeng; Xie, Jing; Hao, Yichang; Xu, Tao; Wang, Xiaofeng
关键词: oleic acid ; renal cell carcinoma ; cell proliferation ; integrin-linked kinase
刊名: ONCOLOGY LETTERS
发表日期: 2013-04-01
DOI: 10.3892/ol.2013.1160
卷: 5, 期:4, 页:1395-1399
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: BREAST-CANCER CELLS ; COUPLED RECEPTOR GPR40 ; FATTY-ACIDS ; THERAPEUTIC TARGET ; PROSTATE-CANCER ; PROTEIN ; PROGRESSION ; STRATEGIES ; OBESITY ; RISK
英文摘要:

An increased risk of renal cell carcinoma (RCC) has been linked with obesity and metabolic syndrome. However, the mechanisms by which lipid metabolic disorders affect the development of RCC remain unclear and highly controversial. Integrin-linked kinase (ILK) is a serine/threonine protein kinase involved in the regulation of tumor cell growth and angiogenesis. In the present study, the effect of free fatty acids in the promotion of RCC progression was investigated by upregulating ILK. Results of the MTT assay indicated that treatment of 786-O cells with oleic acid induced a concentration-dependent increase in cell viability. Flow cytometry analysis revealed that the effect of oleic acid on cell apoptosis was not significant. Following treatment with oleic acid, the expression of ILK, phospho-Akt and G protein-coupled receptor 40 (GPR40) was increased in 786-O cells. These effects were reversed when the expression of ILK was downregulated using specific small interfering RNA. These results indicate that free fatty acids are associated with the development of renal cell carcinoma via activation of the GPR40/ILK/Akt pathway, revealing a novel mechanism for the correlation between metabolic disturbance and renal carcinoma.

语种: 英语
所属项目编号: 31171341
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000321003100057
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51031
Appears in Collections:北京大学第二临床医学院_泌尿外科_期刊论文

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作者单位: Peking Univ, Dept Urol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Zhenhua,Xiao, Yunbei,Yuan, Yeqing,et al. Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells[J]. ONCOLOGY LETTERS,2013,5(4):1395-1399.
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