学科主题临床医学
Plasma microRNA-586 is a new biomarker for acute graft-versus-host disease
Wang, Yinuo1; Zhao, Xiaosu2; Ye, Xiaoyang1; Luo, Hongxue1; Zhao, Tongfeng1; Diao, Yarui3; Zhang, Hongyu4; Lv, Meng2; Zhang, Wei1; Huang, Xiaojun2; Wan, Jun1,5
关键词Acute Graft-versus-host Disease Microrn Mir-586 Allogeneic Hematopoietic Cell Transplantation (Allo-hsct)
刊名ANNALS OF HEMATOLOGY
2015-09-01
DOI10.1007/s00277-015-2414-z
94期:9页:1505-1514
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; STEM-CELL TRANSPLANTATION ; SOLUBLE INTERLEUKIN-2-RECEPTOR ; CIRCULATING MICRORNAS ; SERUM-LEVELS ; T-CELLS ; GVHD ; DIAGNOSIS ; MARKERS ; CANCER
英文摘要

Acute graft-versus-host disease (aGVHD) is one of the major causes of morbidity and mortality in patients receiving allogeneic hematopoietic cell transplantation (allo-HSCT). MicroRNAs (miRs) were found to have the potential to be the new biomarkers of aGVHD. In this study, we collected samples from 98 patients who underwent allo-HSCT; 63 patients developed aGVHD, and 35 patients did not. Plasma samples were collected at three time points (before aGVHD, at the onset of aGVHD, and after aGVHD) from 52 patients, and the miR-586 expression level was detected by quantitative real-time PCR. We found that the plasma miR-586 level was decreased at the onset of grade I-II aGVHD (P=0.074). In contrast, when infections were detected, plasma miR-586 level was increased. Moreover, we detected the miR-586 expression level in patients who had infections but did not have aGVHD, and we found that miR-586 was upregulated (P=0.005). We also compared the plasma miR-586 level at day 7 after transplantation between aGVHD patients and control patients. In the aGVHD group, there was a considerably higher miR-586 expression in comparison with the non-aGVHD group (P < 0.05). A more significant difference between the two groups was found when the patients with infections were excluded (P=0.004). Furthermore, receive operating characteristic (ROC) analysis indicated that a higher expression level of miR-586 at day 7 could predict impending aGVHD. The optimal cutoff value of miR-586 to predict aGVHD was 2200 copies/mu L with a sensitivity of 87.5 % and specificity of 55.0 %, and the area under the curve (AUC) was 0.739 (95 % CI 0.598-0.880, P=0.004). Our study suggests that miR-586 might participate in the occurrence of aGVHD and could be a putative target for novel aGVHD therapy. The plasma level of miR-586 at day 7 after allo-HSCT would be a potential biomarker for predicting the occurrence of aGVHD.

语种英语
WOS记录号WOS:000359013700009
项目编号81000465 ; 81171017 ; 81300440 ; GJHZ20120616153140827 ; JCYJ20120616153316095 ; KQC201105300001A ; 7132181
资助机构National Natural Scientific Foundation of China ; Shenzhen Basic Research Grants ; Peacock Plan Research Grant ; Beijing Natural Science Foundation
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51038
专题北京大学第二临床医学院_北京大学血液病研究所
北京大学第二临床医学院_血液科
北京大学第三临床医学院_呼吸科
作者单位1.Ludwig Inst Canc Res, La Jolla, CA 92093 USA
2.Shenzhen Peking Univ Hong Kong Univ Sci & Technol, Biomed Res Inst, Shenzhen Key Lab Neuronal Struct Biol, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Collaborat Innovat Ctr Hematol, Peking Univ Peoples Hosp, Peking Univ Inst Hematol, Beijing 100871, Peoples R China
4.Peking Univ Shenzhen Hosp, Dept Hematol, Shenzhen 518036, Guangdong, Peoples R China
5.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Wang, Yinuo,Zhao, Xiaosu,Ye, Xiaoyang,et al. Plasma microRNA-586 is a new biomarker for acute graft-versus-host disease[J]. ANNALS OF HEMATOLOGY,2015,94(9):1505-1514.
APA Wang, Yinuo.,Zhao, Xiaosu.,Ye, Xiaoyang.,Luo, Hongxue.,Zhao, Tongfeng.,...&Wan, Jun.(2015).Plasma microRNA-586 is a new biomarker for acute graft-versus-host disease.ANNALS OF HEMATOLOGY,94(9),1505-1514.
MLA Wang, Yinuo,et al."Plasma microRNA-586 is a new biomarker for acute graft-versus-host disease".ANNALS OF HEMATOLOGY 94.9(2015):1505-1514.
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