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学科主题: 基础医学
题名:
Leucine metabolism in regulation of insulin secretion from pancreatic beta cells
作者: Yang, Jichun1; Chi, Yujing1; Burkhardt, Brant R.2,3; Guan, Youfei1; Wolf, Bryan A.2,3
关键词: ATP synthase ; glutamate dehydrogenase ; leucine ; mTOR
刊名: NUTRITION REVIEWS
发表日期: 2010-05-01
DOI: 10.1111/j.1753-4887.2010.00282.x
卷: 68, 期:5, 页:270-279
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: ACTIVATED PROTEIN-KINASE ; CHAIN AMINO-ACIDS ; MTOR-SIGNALING PATHWAY ; RAT SKELETAL-MUSCLE ; GLUTAMATE-DEHYDROGENASE ; ATP SYNTHASE ; INS-1 CELLS ; ALPHA-KETOISOCAPROATE ; UNCOUPLING PROTEIN-2 ; MAMMALIAN TARGET
英文摘要:

Leucine, a branched-chain amino acid that must be supplied in the daily diet, plays an important role in controlling protein synthesis and regulating cell metabolism in various cell types. In pancreatic beta cells, leucine acutely stimulates insulin secretion by serving as both metabolic fuel and allosteric activator of glutamate dehydrogenase to enhance glutaminolysis. Leucine has also been shown to regulate gene transcription and protein synthesis in pancreatic islet beta cells via both mTOR-dependent and -independent pathways at physiological concentrations. Long-term treatment with leucine has been shown to improve insulin secretory dysfunction of human diabetic islets via upregulation of certain key metabolic genes. In vivo, leucine administration improves glycemic control in humans and rodents with type 2 diabetes. This review summarizes and discusses the recent findings regarding the effects of leucine metabolism on pancreatic beta-cell function.

语种: 英语
所属项目编号: NSFC 30870995 ; 30771030 ; DK070744
项目资助者: Natural Science Foundation of China ; Ministry of Education of China ; National Institute of Diabetes, Digestive, and Kidney Diseases
WOS记录号: WOS:000277168900002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51041
Appears in Collections:基础医学院_北京大学糖尿病中心_期刊论文

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作者单位: 1.Univ Penn, Sch Med, Philadelphia, PA 19104 USA
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Ctr Diabet, Beijing 100191, Peoples R China
3.Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Recommended Citation:
Yang, Jichun,Chi, Yujing,Burkhardt, Brant R.,et al. Leucine metabolism in regulation of insulin secretion from pancreatic beta cells[J]. NUTRITION REVIEWS,2010,68(5):270-279.
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