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The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes
Li, Xi1; Lian, Feng-Mei2; Guo, Dong1; Fan, Lan1; Tang, Jie1; Peng, Jing-Bo1; Deng, Hong-Wen1; Liu, Zhao-Qian1; Xiao, Xin-Hua3; Wang, Yan-Rong4; Qu, Ke-Yi5; Deng, Sheng6; Zhong, Qi7; Sha, Yi-Ling8; Zhu, Yan2; Bai, Yu-Jing2; Chen, Xin-Yan2; Zhou, Qiang2; Zhou, Hong-Hao1; Tong, Xiao-Lin2; Zhang, Wei1
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/327629
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]TYPE-2 DIABETES-MELLITUS ; IMPAIRED FASTING GLUCOSE ; INSULIN-RESISTANCE ; BERBERINE ; PHARMACOGENETICS ; GENE ; POLYMORPHISMS ; PREVALENCE ; MEDICINE ; HUMANS
英文摘要

Therapeutic interventions in prediabetes are important in the primary prevention of type 2 diabetes (T2D) and its chronic complications. However, little is known about the pharmacogenetic effect of traditional herbs on prediabetes treatment. A total of 194 impaired glucose tolerance (IGT) subjects were treated with traditional hypoglycemic herbs (Tianqi Jiangtang) for 12 months in this study. DNA samples were genotyped for 184 mutations in 34 genes involved in drug metabolism or transportation. Multinomial logistic regression analysis indicated that rs1142345 (A > G) in the thiopurine S-methyltransferase (TPMT) gene was significantly associated with the hypoglycemic effect of the drug (P = 0.001, FDR P = 0.043). The "G" allele frequencies of rs1142345 in the healthy (subjects reverted from IGT to normal glucose tolerance), maintenance (subjects still had IGT), and deterioration (subjects progressed from IGT to T2D) groups were 0.094, 0.214, and 0.542, respectively. Binary logistic regression analysis indicated that rs1142345 was also significantly associated with the hypoglycemic effect of the drug between the healthy and maintenance groups (p = 0.027, OR = 4.828) and between the healthy and deterioration groups (P = 0.001, OR = 7.811). Therefore, rs1142345 was associated with the clinical effect of traditional hypoglycemic herbs. Results also suggested that TPMT was probably involved in the pharmacological mechanisms of T2D.

语种英语
WOS记录号WOS:000318919500001
项目编号81273595 ; 81001476 ; 30901834 ; 81202594 ; 2012AA02A518 ; 2013ZX09509107 ; IRT0946 ; 2012QNZT086 ; 2012QNZT083 ; 2012QNZT084 ; 12JJ7006 ; 11K073 ; 12K005 ; NCET-10-0843 ; NCET-11-0509
资助机构National Scientific Foundation of China ; 863 Project ; Key New Drug Creation and Development Programme of China ; Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China ; Fundamental Research Funds for the Central Universities ; Science Foundation of Hunan Province
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51043
专题北京大学第三临床医学院_内分泌科
作者单位1.Yiling Hosp, Dept Endocrinol, Yichang 443100, Hubei, Peoples R China
2.Cent S Univ, Inst Clin Pharmacol, Pharmacogenet Res Inst, Changsha 410078, Hunan, Peoples R China
3.China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China
4.China Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Beijing 100730, Peoples R China
5.Peking Univ, Peking Univ Hosp 3, Dept Endocrinol, Beijing 100083, Peoples R China
6.Cent S Univ, Xiangya Hosp, Dept Pharm, Changsha 410078, Hunan, Peoples R China
7.Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410078, Hunan, Peoples R China
8.First Peoples Hosp Hegang, Dept Endocrinol, Hegang 154100, Heilongjiang, Peoples R China
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GB/T 7714
Li, Xi,Lian, Feng-Mei,Guo, Dong,et al. The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Li, Xi.,Lian, Feng-Mei.,Guo, Dong.,Fan, Lan.,Tang, Jie.,...&Zhang, Wei.(2013).The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Li, Xi,et al."The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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