北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 消化科  > 期刊论文
学科主题: 临床医学
题名:
Factors influencing intercellular spaces in the rat esophageal epithelium
作者: Zhang, Dong-Hong; Zhou, Li-Ya; Dong, Xiu-Yun; Cui, Rong-Li; Xue, Yan; Lin, San-Ren
关键词: Esophagus ; Dilated intercellular spaces ; Stress, acute ; Aspirin ; Reflux, acid
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2010-03-07
DOI: 10.3748/wjg.v16.i9.1063
卷: 16, 期:9, 页:1063-1069
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: GASTROESOPHAGEAL-REFLUX DISEASE ; OMEPRAZOLE TREATMENT ; MORPHOLOGICAL FEATURE ; ETHANOL INJURY ; ACID REFLUX ; STRESS ; SYMPTOMS ; LESIONS ; MUCOSA ; PERMEABILITY
英文摘要:

AIM: To evaluate the effect of acute stress, hydrochloric acid, ethanol, aspirin, and prednisolone on the intercellular spaces of the esophageal epithelium.

METHODS: Part I, male Sprague-Dawley rats were randomly divided into eight groups and treated with the damaging or control factors. The esophagus of each rat was macroscopically inspected. Histological changes in mucosal biopsies were examined by light microscopy, and the widths of intercellular spaces were determined by transmission electron microscopy (TEM). Part II, in part I, we found that acute stress and aspirin induced dilated intercellular spaces (DIS) of the esophageal epithelium. Therefore, the effect of acid suppression pretreatment with esomeprazole on esophageal epithelial DIS induced by water immersion and restraint stress (WRS) and aspirin was further investigated to determine the association of DIS with acid reflux. After administration of 0.9% sodium chloride solution or esomeprazole solution orally for five days, rats underwent WRS or intragastric administration of aspirin solution. Esophageal epithelial intercellular spaces were investigated by TEM.

RESULTS: (1) The five damaging factors produced no lesions or inflammation in esophageal mucosa of rats under either gross or routine histological inspections. Esophageal epithelial intercellular space diameters in stress and aspirin groups were significantly greater, nearly three or two-fold respectively, than those in their corresponding control groups (stress model: 0.38 +/- 0.05 mu m v5 0.13 +/- 0.02 mu m, P < 0.01; aspirin model: 0.32 +/- 0.12 mu m vs 0.19 +/- 0.05 mu m, P < 0.01). Neither intragastric administration of hydrochloric acid or ethanol, nor hypodermic injection of prednisolone produced DIS compared with their corresponding control groups (hydrochloric acid model: 0.24 +/- 0.03 mu m vs 0.19 +/- 0.05 mu m, P > 0.05; ethanol model: 0.25 +/- 0.10 mu m vs 0.19 +/- 0.05 mu m, P > 0.05; prednisolone model: 0.20 +/- 0.03 mu m v5 0.14 +/- 0.03 mu m, P > 0.05); and (2) No significant difference in the intercellular space diameters was observed between the group pretreated with esomeprazole and the control group, in both the stress and aspirin models (stress model: 0.35 +/- 0.05 mu m v5 0.37 +/- 0.05 mu m, P > 0.05; aspirin model: 0.24 +/- 0.02 mu m vs 0.27 +/- 0.03 mu m, P > 0.05).

CONCLUSION: Acute stress and aspirin can induce DIS of the esophageal epithelium in rats, and it is not correlated with acid reflux. (C) 2010 Baishideng. All rights reserved.

语种: 英语
WOS记录号: WOS:000275406100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51050
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Dong-Hong,Zhou, Li-Ya,Dong, Xiu-Yun,et al. Factors influencing intercellular spaces in the rat esophageal epithelium[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(9):1063-1069.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Dong-Hong]'s Articles
[Zhou, Li-Ya]'s Articles
[Dong, Xiu-Yun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Dong-Hong]‘s Articles
[Zhou, Li-Ya]‘s Articles
[Dong, Xiu-Yun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace