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学科主题临床医学
Factors influencing intercellular spaces in the rat esophageal epithelium
Zhang, Dong-Hong; Zhou, Li-Ya; Dong, Xiu-Yun; Cui, Rong-Li; Xue, Yan; Lin, San-Ren
关键词Esophagus Dilated Intercellular Spaces Aspirin Stress Acute Reflux Acid
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2010-03-07
DOI10.3748/wjg.v16.i9.1063
16期:9页:1063-1069
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]GASTROESOPHAGEAL-REFLUX DISEASE ; OMEPRAZOLE TREATMENT ; MORPHOLOGICAL FEATURE ; ETHANOL INJURY ; ACID REFLUX ; STRESS ; SYMPTOMS ; LESIONS ; MUCOSA ; PERMEABILITY
英文摘要

AIM: To evaluate the effect of acute stress, hydrochloric acid, ethanol, aspirin, and prednisolone on the intercellular spaces of the esophageal epithelium.

METHODS: Part I, male Sprague-Dawley rats were randomly divided into eight groups and treated with the damaging or control factors. The esophagus of each rat was macroscopically inspected. Histological changes in mucosal biopsies were examined by light microscopy, and the widths of intercellular spaces were determined by transmission electron microscopy (TEM). Part II, in part I, we found that acute stress and aspirin induced dilated intercellular spaces (DIS) of the esophageal epithelium. Therefore, the effect of acid suppression pretreatment with esomeprazole on esophageal epithelial DIS induced by water immersion and restraint stress (WRS) and aspirin was further investigated to determine the association of DIS with acid reflux. After administration of 0.9% sodium chloride solution or esomeprazole solution orally for five days, rats underwent WRS or intragastric administration of aspirin solution. Esophageal epithelial intercellular spaces were investigated by TEM.

RESULTS: (1) The five damaging factors produced no lesions or inflammation in esophageal mucosa of rats under either gross or routine histological inspections. Esophageal epithelial intercellular space diameters in stress and aspirin groups were significantly greater, nearly three or two-fold respectively, than those in their corresponding control groups (stress model: 0.38 +/- 0.05 mu m v5 0.13 +/- 0.02 mu m, P < 0.01; aspirin model: 0.32 +/- 0.12 mu m vs 0.19 +/- 0.05 mu m, P < 0.01). Neither intragastric administration of hydrochloric acid or ethanol, nor hypodermic injection of prednisolone produced DIS compared with their corresponding control groups (hydrochloric acid model: 0.24 +/- 0.03 mu m vs 0.19 +/- 0.05 mu m, P > 0.05; ethanol model: 0.25 +/- 0.10 mu m vs 0.19 +/- 0.05 mu m, P > 0.05; prednisolone model: 0.20 +/- 0.03 mu m v5 0.14 +/- 0.03 mu m, P > 0.05); and (2) No significant difference in the intercellular space diameters was observed between the group pretreated with esomeprazole and the control group, in both the stress and aspirin models (stress model: 0.35 +/- 0.05 mu m v5 0.37 +/- 0.05 mu m, P > 0.05; aspirin model: 0.24 +/- 0.02 mu m vs 0.27 +/- 0.03 mu m, P > 0.05).

CONCLUSION: Acute stress and aspirin can induce DIS of the esophageal epithelium in rats, and it is not correlated with acid reflux. (C) 2010 Baishideng. All rights reserved.

语种英语
WOS记录号WOS:000275406100004
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51050
专题北京大学第三临床医学院_肾内科
北京大学第三临床医学院_消化科
作者单位Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Dong-Hong,Zhou, Li-Ya,Dong, Xiu-Yun,et al. Factors influencing intercellular spaces in the rat esophageal epithelium[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(9):1063-1069.
APA Zhang, Dong-Hong,Zhou, Li-Ya,Dong, Xiu-Yun,Cui, Rong-Li,Xue, Yan,&Lin, San-Ren.(2010).Factors influencing intercellular spaces in the rat esophageal epithelium.WORLD JOURNAL OF GASTROENTEROLOGY,16(9),1063-1069.
MLA Zhang, Dong-Hong,et al."Factors influencing intercellular spaces in the rat esophageal epithelium".WORLD JOURNAL OF GASTROENTEROLOGY 16.9(2010):1063-1069.
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