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学科主题: 基础医学
题名:
Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism
作者: Overstreet, David H.2; Cui, Cai-Lian1,3,4; Ma, Yao-Ying1; Guo, Chang-Yong1; Han, Ji-Sheng1,3,4; Lukas, Scott E.5; Lee, David Y. -W.1
关键词: electroacupuncture ; iP rat ; alcohol ; naltrexone
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2008-10-01
DOI: 10.1007/s11064-008-9791-9
卷: 33, 期:10, 页:2166-2170
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: ETHANOL-DEPENDENT RATS ; ACUPUNCTURE ANALGESIA ; NUCLEUS-ACCUMBENS ; P RATS ; STIMULATION ; DOPAMINE ; RECEPTOR ; RELEASE ; INHIBITION ; EXPRESSION
英文摘要:

Electroacupuncture (EA) has been shown to modify the effects of various drugs of abuse, including alcohol. Inbred P rats were trained to drink alcohol voluntarily and then subjected to two periods of alcohol deprivation lasting 3 days. During the second deprivation, the rats received either EA or sham EA. The rats were pretreated with naltrexone (5 mg/kg) or saline 30 min before each of the EA or sham EA sessions. Approximately 6 h after the last naltrexone or saline treatment, the alcohol tubes were returned and alcohol and water intakes were recorded later at 2, 4, 6, and 24 h. Only EA led to a decrease in alcohol intake, which was most prominent at 6 and 24 h, and this inhibitory effect of EA was blocked by naltrexone, suggesting that activation of the endogenous opiate system may be responsible for EA′s effects on alcohol intake in the alcohol-dependent iP rats.

语种: 英语
所属项目编号: P01-AT002038 ; KO5 DA00343 ; 2003-CB515407
项目资助者: NCCAM and NIAAA ; NIDA ; National Basic Research Programme of China
WOS记录号: WOS:000259190900034
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51051
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Harvard Univ, Bioorgan & Nat Prod Lab, Mailman Res Ctr 317, McLean Hosp,Sch Med, Belmont, MA 02478 USA
2.Univ N Carolina, Bowles Ctr Alcohol Studies, Sch Med, Chapel Hill, NC 27599 USA
3.Peking Univ, Neurosci Res Inst, Hlth Sci Ctr, Beijing 100083, Peoples R China
4.Peking Univ, Dept Neurobiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
5.Harvard Univ, Behav Psychopharmacol Res Lab, McLean Hosp, Sch Med, Belmont, MA 02478 USA

Recommended Citation:
Overstreet, David H.,Cui, Cai-Lian,Ma, Yao-Ying,et al. Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism[J]. NEUROCHEMICAL RESEARCH,2008,33(10):2166-2170.
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