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学科主题基础医学
Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism
Overstreet, David H.2; Cui, Cai-Lian1,3,4; Ma, Yao-Ying1; Guo, Chang-Yong1; Han, Ji-Sheng1,3,4; Lukas, Scott E.5; Lee, David Y. -W.1
关键词Electroacupuncture Ip Rat Alcohol Naltrexone
刊名NEUROCHEMICAL RESEARCH
2008-10-01
DOI10.1007/s11064-008-9791-9
33期:10页:2166-2170
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]ETHANOL-DEPENDENT RATS ; ACUPUNCTURE ANALGESIA ; NUCLEUS-ACCUMBENS ; P RATS ; STIMULATION ; DOPAMINE ; RECEPTOR ; RELEASE ; INHIBITION ; EXPRESSION
英文摘要

Electroacupuncture (EA) has been shown to modify the effects of various drugs of abuse, including alcohol. Inbred P rats were trained to drink alcohol voluntarily and then subjected to two periods of alcohol deprivation lasting 3 days. During the second deprivation, the rats received either EA or sham EA. The rats were pretreated with naltrexone (5 mg/kg) or saline 30 min before each of the EA or sham EA sessions. Approximately 6 h after the last naltrexone or saline treatment, the alcohol tubes were returned and alcohol and water intakes were recorded later at 2, 4, 6, and 24 h. Only EA led to a decrease in alcohol intake, which was most prominent at 6 and 24 h, and this inhibitory effect of EA was blocked by naltrexone, suggesting that activation of the endogenous opiate system may be responsible for EA′s effects on alcohol intake in the alcohol-dependent iP rats.

语种英语
WOS记录号WOS:000259190900034
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/51051
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Harvard Univ, Bioorgan & Nat Prod Lab, Mailman Res Ctr 317, McLean Hosp,Sch Med, Belmont, MA 02478 USA
2.Univ N Carolina, Bowles Ctr Alcohol Studies, Sch Med, Chapel Hill, NC 27599 USA
3.Peking Univ, Neurosci Res Inst, Hlth Sci Ctr, Beijing 100083, Peoples R China
4.Peking Univ, Dept Neurobiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
5.Harvard Univ, Behav Psychopharmacol Res Lab, McLean Hosp, Sch Med, Belmont, MA 02478 USA
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GB/T 7714
Overstreet, David H.,Cui, Cai-Lian,Ma, Yao-Ying,et al. Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism[J]. NEUROCHEMICAL RESEARCH,2008,33(10):2166-2170.
APA Overstreet, David H..,Cui, Cai-Lian.,Ma, Yao-Ying.,Guo, Chang-Yong.,Han, Ji-Sheng.,...&Lee, David Y. -W..(2008).Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism.NEUROCHEMICAL RESEARCH,33(10),2166-2170.
MLA Overstreet, David H.,et al."Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism".NEUROCHEMICAL RESEARCH 33.10(2008):2166-2170.
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