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学科主题基础医学
Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia
Yang, Yan-Rui1; He, Yi1; Zhang, Ying1; Li, Yi1; Li, Yafang1; Han, Yan1; Zhu, Haihao1; Wang, Yun1
关键词Cdk5 Activation Pain Hypersensitization Heat Hyperalgesia
刊名PAIN
2007
DOI10.1016/j.pain.2006.08.008
127期:1-2页:109-120
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]Anesthesiology ; Neurosciences & Neurology
关键词[WOS]PROTEIN-KINASE ; THERMAL HYPERALGESIA ; NEURITE OUTGROWTH ; NEUROPATHIC PAIN ; NERVOUS-SYSTEM ; SPINAL-CORD ; P35 ; RAT ; EXPRESSION ; GROWTH
英文摘要

Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. it is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity. The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative of p35, could only be detected in the dorsal horn neurons. Importantly, in the case of control rats, the p35 protein level was much higher in small- and medium-diameter DRG neurons than it was in large neurons. Following CFA injection, Cdk5 activity was upregulated in both primary sensory and dorsal horn neurons. Cdk5 activation in DRG neurons required p35, whereas p25 was required in the dorsal horn. Intrathecal pretreatment with Roscovitine, a specific inhibitor of Cdk5 activity, and intrathecal delivery of the DN-Cdk5(NI44) gene both alleviated CFA-induced heat hyperalgesia, but not mechanical allodynia. In contrast, overexpression of Cdk5, p35 or p25 in primary sensory and dorsal horn neurons significantly enhanced heat hyperalgesia. We conclude that Cdk5/p35 and Cdk5/p25 complexes in primary sensory and dorsal horn neurons may potentially be involved in nociceptive transmission after inflammation and may be employed in synaptic plasticity underlying pain hypersensitization. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000243881900015
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51054
Collection北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Key Lab Neurosci, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Key Lab Neurosci, Dept Neurobiol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yan-Rui,He, Yi,Zhang, Ying,et al. Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia[J]. PAIN,2007,127(1-2):109-120.
APA Yang, Yan-Rui.,He, Yi.,Zhang, Ying.,Li, Yi.,Li, Yafang.,...&Wang, Yun.(2007).Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia.PAIN,127(1-2),109-120.
MLA Yang, Yan-Rui,et al."Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia".PAIN 127.1-2(2007):109-120.
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