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学科主题基础医学
The structural basis of Ca2+ transport by the Ca2+-ATPase from skeletal sarcoplasmic reticulum
Wei, RS; Wang, PR; Yin, CC
关键词Ca2+-pump (Ca2+-ATPase) crystal structure conformational change
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
2006-03-01
33期:3页:210-220
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]P-TYPE ATPASES ; CALCIUM-PUMP ; CRYSTAL-STRUCTURE ; ION-TRANSPORT ; MECHANISM ; BINDING ; OCCLUSION ; FORMS ; DISSOCIATION ; ACTIVATION
英文摘要

The Ca2+-ATPase of sarcoplasmic reticulum is a Ca2+ pump that plays a key role in regulating cytosol calcium concentration in muscle cells. It undergoes a sequential conformational transition during the transport process. According to the classical E1/E2 theory, in the E1 state the binding sites have high affinity and open to the cytoplasm, whereas in the E2 state the binding sites have low affinity and face the luminal side. Crystal structures of several states during the reaction cycle of Ca2+-ATPase have been solved recently, including a Ca2+-bound form (E1-2Ca(2+)), a Ca2+-unbound form stabilized by a potent inhibitor thapsigargin (TG) (E2-TG), an ATP-bound form (E1-ATP), an E1-P-ADP state, and an E2-Pi state. The details of these crystal structures and the relationship between structure and function of Ca2+-ATPase during reaction cycle were summarized, and the issues to be addressed in future research were raised.

语种中文
WOS记录号WOS:000236134000002
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51055
专题北京大学基础医学院_生物物理学系
北京大学基础医学院
作者单位Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
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GB/T 7714
Wei, RS,Wang, PR,Yin, CC. The structural basis of Ca2+ transport by the Ca2+-ATPase from skeletal sarcoplasmic reticulum[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2006,33(3):210-220.
APA Wei, RS,Wang, PR,&Yin, CC.(2006).The structural basis of Ca2+ transport by the Ca2+-ATPase from skeletal sarcoplasmic reticulum.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,33(3),210-220.
MLA Wei, RS,et al."The structural basis of Ca2+ transport by the Ca2+-ATPase from skeletal sarcoplasmic reticulum".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 33.3(2006):210-220.
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