IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson′s disease
Wang, X1; Lu, YY1; Zhang, HQ1; Wang, K1; He, QH1; Wang, Y1; Liu, XY1; Li, LS1; Wang, XM1
关键词neural progenitor cells Parkinson&prime s disease cell differentiation cell transplantation migration dopaminergic neurons central nervous system
刊名INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
2004-06-01
DOI10.1016/j.ijdevneu.2004.05.008
22期:4页:175-183
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Developmental Biology ; Neurosciences
研究领域[WOS]Developmental Biology ; Neurosciences & Neurology
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; STEM-CELLS ; DOPAMINE NEURONS ; NEUROTROPHIC FACTOR ; ADULT-RAT ; HUMAN NEUROSPHERES ; PRECURSOR CELLS ; TRANSPLANTATION ; SURVIVAL ; BRAIN
英文摘要

Neural progenitor cells have shown the effectiveness in the treatment of Parkinson′s disease, but the therapeutic efficacy remains variable. One of important factors that determine the efficacy is the necessity of pre-differentiation of progenitor cells into dopaminergic neurons before transplantation. This study therefore investigated the therapeutic efficacy of mesencephalon-derived human neural progenitor cells with or without the pre-differentiation in alleviating a rat model of Parkinson′s disease. We found that a combination of 50 ng/ml fibroblast growth factor 8, 10 ng/ml glial cell line-derived neurotrophic factor and 10 muM forskolin facilitated the differentiation of human fetal mesencephalic progenitor cells into dopaminergic neurons in vitro. More importantly, after transplanted into the striatum of parkinsonian rats, only pre-differentiated grafts resulted in an elevated production of dopamine in the transplanted site and the amelioration of behavioral impairments of the parkinsonian rats. Unlike pre-differentiated progenitors, grafted intact progenitors rarely differentiated into dopaminergic neurons in vivo and emigrated actively away from the transplanted site.

These data demonstrates the importance of pre-differentiation of human progenitor cells before transplantation in enhancing therapeutic potency for Parkinson′s disease. (C) 2004 ISDN. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000222953500001
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51056
专题北京大学基础医学院_神经生物学系
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学药学院_化学生物学系
北京大学第一临床医学院_口腔科
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Stem Cell Res Ctr, Beijing 100083, Peoples R China
3.Capital Univ Med Sci, Dept Physiol, Beijing 100054, Peoples R China
推荐引用方式
GB/T 7714
Wang, X,Lu, YY,Zhang, HQ,等. Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson′s disease[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2004,22(4):175-183.
APA Wang, X.,Lu, YY.,Zhang, HQ.,Wang, K.,He, QH.,...&Wang, XM.(2004).Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson′s disease.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,22(4),175-183.
MLA Wang, X,et al."Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson′s disease".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 22.4(2004):175-183.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Distinct efficacy of(365KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, X]的文章
[Lu, YY]的文章
[Zhang, HQ]的文章
百度学术
百度学术中相似的文章
[Wang, X]的文章
[Lu, YY]的文章
[Zhang, HQ]的文章
必应学术
必应学术中相似的文章
[Wang, X]的文章
[Lu, YY]的文章
[Zhang, HQ]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson′s disease.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。