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学科主题: 基础医学
题名:
Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson′s disease
作者: Wang, X1; Lu, YY1; Zhang, HQ1; Wang, K1; He, QH1; Wang, Y1; Liu, XY1; Li, LS1; Wang, XM1
关键词: neural progenitor cells ; Parkinson&prime ; s disease ; cell differentiation ; cell transplantation ; migration ; dopaminergic neurons ; central nervous system
刊名: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
发表日期: 2004-06-01
DOI: 10.1016/j.ijdevneu.2004.05.008
卷: 22, 期:4, 页:175-183
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Developmental Biology ; Neurosciences
研究领域[WOS]: Developmental Biology ; Neurosciences & Neurology
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; STEM-CELLS ; DOPAMINE NEURONS ; NEUROTROPHIC FACTOR ; ADULT-RAT ; HUMAN NEUROSPHERES ; PRECURSOR CELLS ; TRANSPLANTATION ; SURVIVAL ; BRAIN
英文摘要:

Neural progenitor cells have shown the effectiveness in the treatment of Parkinson′s disease, but the therapeutic efficacy remains variable. One of important factors that determine the efficacy is the necessity of pre-differentiation of progenitor cells into dopaminergic neurons before transplantation. This study therefore investigated the therapeutic efficacy of mesencephalon-derived human neural progenitor cells with or without the pre-differentiation in alleviating a rat model of Parkinson′s disease. We found that a combination of 50 ng/ml fibroblast growth factor 8, 10 ng/ml glial cell line-derived neurotrophic factor and 10 muM forskolin facilitated the differentiation of human fetal mesencephalic progenitor cells into dopaminergic neurons in vitro. More importantly, after transplanted into the striatum of parkinsonian rats, only pre-differentiated grafts resulted in an elevated production of dopamine in the transplanted site and the amelioration of behavioral impairments of the parkinsonian rats. Unlike pre-differentiated progenitors, grafted intact progenitors rarely differentiated into dopaminergic neurons in vivo and emigrated actively away from the transplanted site.

These data demonstrates the importance of pre-differentiation of human progenitor cells before transplantation in enhancing therapeutic potency for Parkinson′s disease. (C) 2004 ISDN. Published by Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000222953500001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51056
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Stem Cell Res Ctr, Beijing 100083, Peoples R China
3.Capital Univ Med Sci, Dept Physiol, Beijing 100054, Peoples R China

Recommended Citation:
Wang, X,Lu, YY,Zhang, HQ,et al. Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson′s disease[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2004,22(4):175-183.
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