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学科主题: 基础医学
题名:
Transforming growth factor-beta(1) deteriorates microrheological characteristics and motility of mature dendritic cells in concentration-dependent fashion
作者: Zheng, Qinni1,2; Long, Jinhua3,4; Jia, Binbin6; Xu, Xiaoli1,2; Zhang, Chunlin2; Li, Long7; Wen, Zongyao5; Jin, Feng3,4; Yao, Weijuan5; Zeng, Zhu1,2
关键词: Mature dendritic cells ; transforming growth factor-beta(1) ; microrheological characteristics ; immune escape mechanism of tumor
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2014
DOI: 10.3233/CH-121653
卷: 56, 期:1, 页:25-40
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: MURINE ERYTHROLEUKEMIA-CELLS ; TGF-BETA ; CANCER PROGRESSION ; TUMOR-CELLS ; LYMPH-NODES ; P53 GENE ; METASTASIS ; FASCIN ; DIFFERENTIATION ; REORGANIZATION
英文摘要:

Dendritic cells (DCs) are potent and specialized antigen-presenting cells that play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Tumor cells can escape from immune attack by secreting suppressive cytokines which solely or cooperatively impair the immune function and microrheological properties of DCs. However, the underlying mechanisms are not fully defined. Transforming growth factor-beta(1) (TGF-beta(1)) has been identified as a major cytokine in the tumor microenvironment. To determine the effects of TGF-beta(1) on mature DCs (mDCs) from microrheological viewpoint, cells were treated with different concentrations of TGF-beta(1). The results showed that the impaired microrheological parameters, including osmotic fragility, electrophoretic mobility, deformability, membrane fluidity, F-actin organization and so on, as well as motilities of mDCs relied heavily on TGF-beta(1) concentration. Moreover, these changes were correlated with the expression levels of fascin1, cofilin1, phosphorylated cofilin1 and profilin, this could be one of the crucial aspects of immune escape mechanisms of tumors, hinting that the signal pathway of TGF-beta(1) should be blocked in appropriate way before performing DCs-based immunotherapy against cancer. It is clinically important to understand the biological behavior of DCs and immune escape mechanism of tumor as well as how to improve efficiency of the anti-tumor therapy based on DCs.

语种: 英语
所属项目编号: 11162003 ; 31260227 ; 31170886 ; 210196 ; 201124 ; GZ-SY-[2011]-3065 ; 2009-79 ; J-2008-2274 ; 2010-1-12
项目资助者: National Natural Science Foundations of China ; Key Project of Chinese Ministry of Education ; Supporting Project of Distinguished Young Science and Technology Scholars of Guizhou Province ; Offends Pass Item of Science and Technology for Social Development in Guizhou Province ; Special Foundation of Governor of Guizhou Province ; Foundation of Science and Technology of Guizhou Province ; Foundation of Science and Technology of Guiyang of Guizhou Province
WOS记录号: WOS:000332245300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51065
Appears in Collections:基础医学院_北京大学血液流变中心_期刊论文

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作者单位: 1.Chengde Med Coll, Dept Med Phys, Chengde, Hebei Province, Peoples R China
2.Guiyang Med Coll, Dept Biotechnol, Guiyang 550004, Guizhou Provinc, Peoples R China
3.Guiyang Med Coll, Dept Cell Biol, Guiyang 550004, Guizhou Provinc, Peoples R China
4.Guiyang Med Coll, Dept Head & Neck, Affiliated Hosp, Guiyang 550004, Guizhou Provinc, Peoples R China
5.Guiyang Med Coll, Canc Hosp, Guiyang 550004, Guizhou Provinc, Peoples R China
6.Peking Univ, Hemorheol Ctr, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
7.Guiyang Med Coll, Affiliated Hosp, Dept Nephrol, Guiyang 550004, Guizhou Provinc, Peoples R China

Recommended Citation:
Zheng, Qinni,Long, Jinhua,Jia, Binbin,et al. Transforming growth factor-beta(1) deteriorates microrheological characteristics and motility of mature dendritic cells in concentration-dependent fashion[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2014,56(1):25-40.
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