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学科主题口腔医学
Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction
Su, Jia-Zeng1; Yang, Ning-Yan1; Liu, Xiao-Jing1; Cai, Zhi-Gang1; Lv, Lan2; Zhang, Lei1; Wu, Li-Ling3,4; Liu, Deng-Gao5; Ren, Wen-Ge5; Gao, Yan6; Yu, Guang-Yan1
刊名BRITISH JOURNAL OF OPHTHALMOLOGY
2014-12-01
DOI10.1136/bjophthalmol-2014-305117
98期:12页:1672-1677
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]SEVERE KERATOCONJUNCTIVITIS SICCA ; DRY EYE ; CLASSIFICATION ; DIAGNOSIS ; SECRETION
英文摘要

Aims To determine the pathological basis and clinical features of obstructive sialadenitis in transplanted submandibular glands (SMGs).

Methods A total of 161 patients (174 eyes) with keratoconjunctivitis sicca underwent microvascular SMG transplantation. Patients were followed up at approximately 1 and 4 months and annually thereafter. Clinical data, including dry eye discomfort, symptoms of ductal obstruction, and Schirmer test, were recorded. Sialography was performed in six patients. In addition, SMG autotransplantation was performed in 22 rabbits. Salivary flow was recorded and the morphology of glands was examined at 6 months postoperatively by light microscopy.

Results Among the patients, 16 out of 172 glands during the latent period (0-3 months) and 2 out of 154 glands with long-term follow-up (>1 year) showed obstructive sialadenitis. Typical manifestations were continuous small volumes of viscous secretions, recurrent gland swelling, decreased Schirmer test values, and irregular dilation of the main duct on sialography. The transplanted SMGs eventually showed no secretion in five cases. Of the 22 rabbit SMGs, 4 had obstructive sialadenitis. Morphological examination showed chronic inflammatory infiltration with salivary deposits.

Conclusions Obstructive sialadenitis of transplanted SMGs is a chronic inflammation secondary to ductal obstruction, which leads to insufficient ocular lubrication and potential treatment failure.

语种英语
WOS记录号WOS:000345284300013
项目编号81271161 ; 20120001110045 ; 7132201
资助机构National Natural Science Foundation of China ; Ministry of Education ; Beijing Natural Science Foundation
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51066
专题北京大学口腔医学院_医学影像科
北京大学基础医学院
北京大学口腔医学院_口腔放射科
北京大学口腔医学院_外科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
3.Capital Univ Med Sci, Affiliated Beijing Tong Ren Hosp, Dept Ophthalmol, Beijing, Peoples R China
4.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100081, Peoples R China
5.Peking Univ, Sch & Hosp Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China
6.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Su, Jia-Zeng,Yang, Ning-Yan,Liu, Xiao-Jing,et al. Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction[J]. BRITISH JOURNAL OF OPHTHALMOLOGY,2014,98(12):1672-1677.
APA Su, Jia-Zeng.,Yang, Ning-Yan.,Liu, Xiao-Jing.,Cai, Zhi-Gang.,Lv, Lan.,...&Yu, Guang-Yan.(2014).Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction.BRITISH JOURNAL OF OPHTHALMOLOGY,98(12),1672-1677.
MLA Su, Jia-Zeng,et al."Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction".BRITISH JOURNAL OF OPHTHALMOLOGY 98.12(2014):1672-1677.
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