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学科主题: 口腔医学
题名:
Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction
作者: Su, Jia-Zeng1; Yang, Ning-Yan1; Liu, Xiao-Jing1; Cai, Zhi-Gang1; Lv, Lan2; Zhang, Lei1; Wu, Li-Ling3,4; Liu, Deng-Gao5; Ren, Wen-Ge5; Gao, Yan6; Yu, Guang-Yan1
刊名: BRITISH JOURNAL OF OPHTHALMOLOGY
发表日期: 2014-12-01
DOI: 10.1136/bjophthalmol-2014-305117
卷: 98, 期:12, 页:1672-1677
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: SEVERE KERATOCONJUNCTIVITIS SICCA ; DRY EYE ; CLASSIFICATION ; DIAGNOSIS ; SECRETION
英文摘要:

Aims To determine the pathological basis and clinical features of obstructive sialadenitis in transplanted submandibular glands (SMGs).

Methods A total of 161 patients (174 eyes) with keratoconjunctivitis sicca underwent microvascular SMG transplantation. Patients were followed up at approximately 1 and 4 months and annually thereafter. Clinical data, including dry eye discomfort, symptoms of ductal obstruction, and Schirmer test, were recorded. Sialography was performed in six patients. In addition, SMG autotransplantation was performed in 22 rabbits. Salivary flow was recorded and the morphology of glands was examined at 6 months postoperatively by light microscopy.

Results Among the patients, 16 out of 172 glands during the latent period (0-3 months) and 2 out of 154 glands with long-term follow-up (>1 year) showed obstructive sialadenitis. Typical manifestations were continuous small volumes of viscous secretions, recurrent gland swelling, decreased Schirmer test values, and irregular dilation of the main duct on sialography. The transplanted SMGs eventually showed no secretion in five cases. Of the 22 rabbit SMGs, 4 had obstructive sialadenitis. Morphological examination showed chronic inflammatory infiltration with salivary deposits.

Conclusions Obstructive sialadenitis of transplanted SMGs is a chronic inflammation secondary to ductal obstruction, which leads to insufficient ocular lubrication and potential treatment failure.

语种: 英语
所属项目编号: 81271161 ; 20120001110045 ; 7132201
项目资助者: National Natural Science Foundation of China ; Ministry of Education ; Beijing Natural Science Foundation
WOS记录号: WOS:000345284300013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51066
Appears in Collections:北京大学口腔医学院_医学影像科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
3.Capital Univ Med Sci, Affiliated Beijing Tong Ren Hosp, Dept Ophthalmol, Beijing, Peoples R China
4.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100081, Peoples R China
5.Peking Univ, Sch & Hosp Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China
6.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China

Recommended Citation:
Su, Jia-Zeng,Yang, Ning-Yan,Liu, Xiao-Jing,et al. Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction[J]. BRITISH JOURNAL OF OPHTHALMOLOGY,2014,98(12):1672-1677.
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