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学科主题: 临床医学
题名:
Association of the-183 polymorphism in the IFN-gamma gene promoter with hepatitis B virus infection in the Chinese population
作者: Qi, SX1; Cao, BW1; Jiang, MW1; Xu, CQ1; Dai, Y1; Li, K1; Wang, K1; Ke, Y1; Ning, T1
关键词: hepatitis B virus ; IFN-gamma ; promoter ; polymorphism ; susceptibility
刊名: JOURNAL OF CLINICAL LABORATORY ANALYSIS
发表日期: 2005
DOI: 10.1002/jcla.20090
卷: 19, 期:6, 页:276-281
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: SINGLE NUCLEOTIDE POLYMORPHISM ; EXPRESSION ; CELLS
英文摘要:

Interferon-gamma (IFN-gamma) is a pleiotropic cytokine that plays an important role in regulating cellular immune responses. Regulation of IFN-gamma expression is considered to be strictly controlled at the transcriptional level. Two single-nucleotide polymorphisms (SNPs) within the human IFN-gamma promoter (at positions -183 and -155) are considered to influence the promoter activity by altering the acting transcription factor-1 (AP-1) binding. We sought to assess the association between the SNPs of the IFN-gamma promoter and the host susceptibility to hepatitis B virus (HBV) infection, as well as its interaction with age and gender. No polymorphism at position-155 was detected in any of the participants, but a significant difference was found in the polymorphism at position -183 between the cases and controls (G/T and T/T vs. GG; P< 0.01, odds ratio (OR) = 4.50 (95% confidence interval (Cl) = 2.23-9.09). A susceptibility analysis revealed a gradually increased trend of the OR value from the young to the old group (OR = 3.03, 4.17, and 5.56). Similarly, the association of the -183 polymorphism was markedly different in females (OR = 5.71). Our data suggest that the polymorphism at position -183 of the IFN-gamma gene promoter may be associated with susceptibility to HBV infection, and age and gender factors are coordinative risk factors.

语种: 英语
WOS记录号: WOS:000233701100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51067
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Qianfo Hosp, Jinan, Shandong, Peoples R China
2.Peking Univ, Hosp 1, Beijing, Peoples R China
3.Xuzhou 1 Peoples Hosp, Xuzhou, Jiangsu, Peoples R China
4.Peking Univ, Dept Genet, Beijing Inst Canc Res, Sch Oncol, Beijing 100034, Peoples R China
5.Shandong Univ, Coll Med, Jinan 250100, Shandong, Peoples R China

Recommended Citation:
Qi, SX,Cao, BW,Jiang, MW,et al. Association of the-183 polymorphism in the IFN-gamma gene promoter with hepatitis B virus infection in the Chinese population[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2005,19(6):276-281.
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