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学科主题: 临床医学
题名:
Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder
作者: Hou, Haifeng1,2,3,4; Jia, Shaowe5; Hu, Shu5; Fan, Rong5; Sun, Wen5; Sun, Taotao5; Zhang, Hong1,2,3,4
刊名: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
发表日期: 2012
DOI: 10.1155/2012/854524
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: DEPENDENT PATIENTS ; HEROIN USERS ; VIDEO GAME ; RELEASE ; METHAMPHETAMINE ; TOMOGRAPHY ; ABSTINENCE ; MARKERS ; ABUSERS ; GENES
英文摘要:

In recent years, internet addiction disorder (IAD) has become more prevalent worldwide and the recognition of its devastating impact on the users and society has rapidly increased. However, the neurobiological mechanism of IAD has not bee fully expressed. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in individuals with IAD. SPECT brain scans were acquired on 5 male IAD subjects and 9 healthy age-matched controls. The volume (V) and weight (W) of bilateral corpus striatum as well as the Tc-99m-TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models. It was displayed that DAT expression level of striatum was significantly decreased and the V, W, and Ra were greatly reduced in the individuals with IAD compared to controls. Taken together, these results suggest that IAD may cause serious damages to the brain and the neuroimaging findings further illustrate IAD is associated with dysfunctions in the dopaminergic brain systems. Our findings also support the claim that IAD may share similar neurobiological abnormalities with other addictive disorders.

语种: 英语
所属项目编号: Z2110230 ; 2010ZA075 ; 2011ZDA013 ; 81101023 ; 81170306 ; 81173468 ; 2011CB504400 ; 2012BAI13B06
项目资助者: Zhejiang Provincial Natural Science Foundation of China ; Health Bureau of Zhejiang Province ; National Science Foundation of China (NSFC) ; Ministry of Science and Technology of China
WOS记录号: WOS:000302686700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51068
Appears in Collections:北京大学深圳医院_核医学科_期刊论文

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作者单位: 1.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China
2.Zhejiang Univ, Med PET Ctr, Hangzhou 310009, Zhejiang, Peoples R China
3.Zhejiang Univ, Inst Nucl Med & Mol Imaging, Hangzhou 310009, Zhejiang, Peoples R China
4.Key Lab Med Mol Imaging Zhejiang Prov, Hangzhou 310009, Zhejiang, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Nucl Med, Shenzhen 310009, Peoples R China

Recommended Citation:
Hou, Haifeng,Jia, Shaowe,Hu, Shu,et al. Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,2012.
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