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学科主题临床医学
Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder
Hou, Haifeng1,2,3,4; Jia, Shaowe5; Hu, Shu5; Fan, Rong5; Sun, Wen5; Sun, Taotao5; Zhang, Hong1,2,3,4
刊名JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
2012
DOI10.1155/2012/854524
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]DEPENDENT PATIENTS ; HEROIN USERS ; VIDEO GAME ; RELEASE ; METHAMPHETAMINE ; TOMOGRAPHY ; ABSTINENCE ; MARKERS ; ABUSERS ; GENES
英文摘要

In recent years, internet addiction disorder (IAD) has become more prevalent worldwide and the recognition of its devastating impact on the users and society has rapidly increased. However, the neurobiological mechanism of IAD has not bee fully expressed. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in individuals with IAD. SPECT brain scans were acquired on 5 male IAD subjects and 9 healthy age-matched controls. The volume (V) and weight (W) of bilateral corpus striatum as well as the Tc-99m-TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models. It was displayed that DAT expression level of striatum was significantly decreased and the V, W, and Ra were greatly reduced in the individuals with IAD compared to controls. Taken together, these results suggest that IAD may cause serious damages to the brain and the neuroimaging findings further illustrate IAD is associated with dysfunctions in the dopaminergic brain systems. Our findings also support the claim that IAD may share similar neurobiological abnormalities with other addictive disorders.

语种英语
WOS记录号WOS:000302686700001
项目编号Z2110230 ; 2010ZA075 ; 2011ZDA013 ; 81101023 ; 81170306 ; 81173468 ; 2011CB504400 ; 2012BAI13B06
资助机构Zhejiang Provincial Natural Science Foundation of China ; Health Bureau of Zhejiang Province ; National Science Foundation of China (NSFC) ; Ministry of Science and Technology of China
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51068
专题北京大学深圳医院_核医学科
北京大学临床肿瘤学院_财务处
作者单位1.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China
2.Zhejiang Univ, Med PET Ctr, Hangzhou 310009, Zhejiang, Peoples R China
3.Zhejiang Univ, Inst Nucl Med & Mol Imaging, Hangzhou 310009, Zhejiang, Peoples R China
4.Key Lab Med Mol Imaging Zhejiang Prov, Hangzhou 310009, Zhejiang, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Nucl Med, Shenzhen 310009, Peoples R China
推荐引用方式
GB/T 7714
Hou, Haifeng,Jia, Shaowe,Hu, Shu,et al. Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,2012.
APA Hou, Haifeng.,Jia, Shaowe.,Hu, Shu.,Fan, Rong.,Sun, Wen.,...&Zhang, Hong.(2012).Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder.JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY.
MLA Hou, Haifeng,et al."Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder".JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012).
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