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学科主题: 精神卫生
题名:
Near-infrared spectroscopy for examination of prefrontal activation during cognitive tasks in patients with major depressive disorder: A meta-analysis of observational studies
作者: Zhang, Huijun1; Dong, Wentian1; Dang, Weimin1; Quan, Wenxiang1; Tian, Ju1; Chen, Ru2; Zhan, Siyan2; Yu, Xin1
关键词: major depressive disorder ; meta-analysis ; near-infrared spectroscopy ; neuroimaging ; prefrontal cortex
刊名: PSYCHIATRY AND CLINICAL NEUROSCIENCES
发表日期: 2015
DOI: 10.1111/pcn.12209
卷: 69, 期:1, 页:22-33
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: VERBAL FLUENCY TASK ; BRAIN ACTIVATION ; HEMOGLOBIN OXYGENATION ; UNIPOLAR DEPRESSION ; BIPOLAR DISORDER ; WORKING-MEMORY ; NIRS ; BOLD ; HYPOFRONTALITY ; PERFORMANCE
英文摘要:

AimsNear-infrared spectroscopy has the potential for aiding the diagnosis of major depressive disorder. The purpose of this study was to systematically review the evidence from observational studies regarding the use of near-infrared spectroscopy in patients with major depressive disorder and to identify the characteristic pattern of prefrontal lobe activity in major depressive disorder.

Methodsmedline, PubMed, Cochrane Library and Web of Science databases were searched in December 2013. All case-control studies were included. The quality of evidence was examined using the Newcastle-Ottawa Quality Assessment Scale. The primary outcome measures were the mean oxygenated and deoxygenated hemoglobin alterations of the cerebral cortex during cognitive activation periods. The standard mean difference for the overall pooled effects across the included studies was estimated using random or fixed effect models. The primary outcome measures were included in the meta-analysis.

ResultsFourteen studies met the inclusion criteria. Six studies (n=692 participants) were included in the analysis of the mean oxygenated hemoglobin alterations; the pooled mean standardized difference was -0.74 (95% confidence interval, -0.97 to -0.52), indicating that patients with major depressive disorder were associated with attenuated increase in oxygenated hemoglobin during cognitive activation in the prefrontal regions compared to healthy controls. Five studies (n=668 participants) were included in the analysis of mean deoxygenated-hemoglobin changes; the pooled standardized mean difference was 0.18 (95% confidence interval, -0.20 to 0.56).

ConclusionsUsing near-infrared spectroscopy measurements, we observed that compared to healthy subjects, patients with major depressive disorder had significantly lower prefrontal activation during cognitive tasks.

语种: 英语
WOS记录号: WOS:000347328800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51079
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Minist Hlth, Inst Mental Hlth, Key Lab Mental Hlth,Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Huijun,Dong, Wentian,Dang, Weimin,et al. Near-infrared spectroscopy for examination of prefrontal activation during cognitive tasks in patients with major depressive disorder: A meta-analysis of observational studies[J]. PSYCHIATRY AND CLINICAL NEUROSCIENCES,2015,69(1):22-33.
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