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学科主题: 基础医学
题名:
Overexpression of LAPTM4B-35 in Cervical Carcinoma: A Clinicopathologic Study
作者: Meng, Fanling1; Luo, Chang1; Hu, Yuanlong2; Yin, Mingzhu1; Lin, Ming3; Lou, Ge1; Zhou, Rouli3
关键词: Lysosomal protein transmembrane 4 beta ; immunohistochemistry ; cervical carcinoma ; prognosis
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
发表日期: 2010-11-01
DOI: 10.1097/PGP.0b013e3181e0898e
卷: 29, 期:6, 页:587-593
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Pathology
研究领域[WOS]: Obstetrics & Gynecology ; Pathology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; CANCER ; PROGRESSION ; EXPRESSION ; PROTEIN ; PROGNOSIS ; MARKER ; SEEMS ; PLAY
英文摘要:

Lysosome-associated protein transmembrane 4 beta-35 (LAPTM4B-35) is a member of the mammalian 4-tetratransmembrane spanning protein superfamily, which is overexpressed in several solid malignancies. However, the expression of LAPTM4 B-35 and its role in the progression of cervical carcinoma is unknown. The aim of this study was to determine the level of expression of LAPTM4B-35 in cervical carcinoma. Immunohistochemistry was used to determine the expression of LAPTM4B-35 protein in 53 cervical intraepithelial neoplasias (CINs) and 113 cervical carcinomas in comparison with 20 normal cervical specimens. The correlation between the expression of the LAPTM4B-35 protein and the clinicopathologic characteristics of patients with cervical carcinoma was analyzed. Statistical analysis showed that LAPTM4B-35 expression was significantly elevated in CINII/III and cervical carcinoma but not in CINI compared with the normal controls (P = 0.002, P < 0.001 and P = 0.289, respectively). In addition, the LAPTM4B-35 expression was significantly higher in both the CINII/III and cervical carcinoma cases than in the CINI cases (P = 0.021 and P = 0.002, respectively). High LAPTM4B-35 staining was present in 72.57% (82 of 113) of all the cases with cervical carcinoma. The overexpression of LAPTM4B-35 was significantly associated with the International Federation of Gynecology and Obstetrics stage (P = 0.014), tumor histologic grade (P = 0.033), lymph node metastasis (P = 0.045), and recurrence (P = 0.010). The Kaplan-Meier survival analysis showed that the high expression of LAPTM4B-35 was related to the poor overall survival and disease-free survival of patients with cervical carcinoma (P = 0.004 and P = 0.005, respectively). Multivariate Cox analysis showed that LAPTM4B-35 was an independent factor for both overall survival and disease-free survival (P = 0.015 and P = 0.016, respectively). Overexpression of LAPTM4B-35 may be associated with tumor progression in cervical carcinoma and thus may serve as a new molecular marker to predict the prognosis of cervical carcinoma patients.

语种: 英语
WOS记录号: WOS:000283264400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51080
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Fifth Hosp, Dept Orthopaed, Harbin, Peoples R China
2.Harbin Med Univ, Affiliated Tumor Hosp, Dept Gynecol, Harbin 150081, Peoples R China
3.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Meng, Fanling,Luo, Chang,Hu, Yuanlong,et al. Overexpression of LAPTM4B-35 in Cervical Carcinoma: A Clinicopathologic Study[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY,2010,29(6):587-593.
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