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Leukocyte functions in 2 cases of Papillon-Lefevre syndrome
Liu, RK; Cao, CF; Meng, HX; Tang, ZH
关键词Papillon-lefevre Syndrome Polymorphonuclear Leukocyte Chemotaxis Monocytes Interleukin-8 Elastase
刊名JOURNAL OF CLINICAL PERIODONTOLOGY
2000
27期:1页:69-73
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]EARLY-ONSET PERIODONTITIS ; NEUTROPHIL-ACTIVATING FACTOR ; GINGIVAL CREVICULAR FLUID ; GRANULOCYTE ELASTASE ; MOLECULAR-BASIS ; DYSFUNCTION ; CHEMOTAXIS ; RECEPTOR ; SIBLINGS ; PROTEIN
英文摘要

Aim: To investigate the role of leukocytes in the pathogenesis of Papillon-Lefevre syndrome (PLS).

Methods: Peripheral blood polymorphonuclear neutrophils (PMNs), monocytes (MNs) and gingival crevicular fluid (GCF) were obtained from 2 cases of PLS with typical features. The chemotaxis of PMNs and MNs were evaluated using a modified Boyden chamber. The adherence of PMNs was determined by adherence of PMNs to petri dishes. Interleukin-8 (IL-8) in GCF was detected by sandwich ELISA. Elastase activity in GCF was measured with a low molecular weight substrate (S-2484) specific for granulocyte elastase.

Results: PMNs from both patients showed depressed chemotactic response to FMLP and IL-8. Total amounts of IL-8 in GCF from the 2 patients were much higher than those of the normal controls. Elastase activity was not significantly different from that of the controls. The adherence of PMN and the chemotaxis of MN in the 2 patients were normal.

Conclusion: The depressed chemotactic response of PMN leads to decreased recruitment of PMN and/or release of lysozyme from PMN in the diseased gingival tissue, increasing the susceptibility of PLS patients to periodontal infection.

语种英语
WOS记录号WOS:000084576700010
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51082
专题北京大学口腔医学院_牙周科
北京大学口腔医学院_第二门诊部
作者单位Beijing Med Univ, Sch Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Liu, RK,Cao, CF,Meng, HX,et al. Leukocyte functions in 2 cases of Papillon-Lefevre syndrome[J]. JOURNAL OF CLINICAL PERIODONTOLOGY,2000,27(1):69-73.
APA Liu, RK,Cao, CF,Meng, HX,&Tang, ZH.(2000).Leukocyte functions in 2 cases of Papillon-Lefevre syndrome.JOURNAL OF CLINICAL PERIODONTOLOGY,27(1),69-73.
MLA Liu, RK,et al."Leukocyte functions in 2 cases of Papillon-Lefevre syndrome".JOURNAL OF CLINICAL PERIODONTOLOGY 27.1(2000):69-73.
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