|Leukocyte functions in 2 cases of Papillon-Lefevre syndrome|
|Liu, RK; Cao, CF; Meng, HX; Tang, ZH|
|关键词||Papillon-lefevre Syndrome Polymorphonuclear Leukocyte Chemotaxis Monocytes Interleukin-8 Elastase|
|刊名||JOURNAL OF CLINICAL PERIODONTOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Dentistry, Oral Surgery & Medicine|
|研究领域[WOS]||Dentistry, Oral Surgery & Medicine|
|关键词[WOS]||EARLY-ONSET PERIODONTITIS ; NEUTROPHIL-ACTIVATING FACTOR ; GINGIVAL CREVICULAR FLUID ; GRANULOCYTE ELASTASE ; MOLECULAR-BASIS ; DYSFUNCTION ; CHEMOTAXIS ; RECEPTOR ; SIBLINGS ; PROTEIN|
Aim: To investigate the role of leukocytes in the pathogenesis of Papillon-Lefevre syndrome (PLS).
Methods: Peripheral blood polymorphonuclear neutrophils (PMNs), monocytes (MNs) and gingival crevicular fluid (GCF) were obtained from 2 cases of PLS with typical features. The chemotaxis of PMNs and MNs were evaluated using a modified Boyden chamber. The adherence of PMNs was determined by adherence of PMNs to petri dishes. Interleukin-8 (IL-8) in GCF was detected by sandwich ELISA. Elastase activity in GCF was measured with a low molecular weight substrate (S-2484) specific for granulocyte elastase.
Results: PMNs from both patients showed depressed chemotactic response to FMLP and IL-8. Total amounts of IL-8 in GCF from the 2 patients were much higher than those of the normal controls. Elastase activity was not significantly different from that of the controls. The adherence of PMN and the chemotaxis of MN in the 2 patients were normal.
Conclusion: The depressed chemotactic response of PMN leads to decreased recruitment of PMN and/or release of lysozyme from PMN in the diseased gingival tissue, increasing the susceptibility of PLS patients to periodontal infection.
|作者单位||Beijing Med Univ, Sch Stomatol, Dept Periodontol, Beijing 100081, Peoples R China|
|Liu, RK,Cao, CF,Meng, HX,et al. Leukocyte functions in 2 cases of Papillon-Lefevre syndrome[J]. JOURNAL OF CLINICAL PERIODONTOLOGY,2000,27(1):69-73.|
|APA||Liu, RK,Cao, CF,Meng, HX,&Tang, ZH.(2000).Leukocyte functions in 2 cases of Papillon-Lefevre syndrome.JOURNAL OF CLINICAL PERIODONTOLOGY,27(1),69-73.|
|MLA||Liu, RK,et al."Leukocyte functions in 2 cases of Papillon-Lefevre syndrome".JOURNAL OF CLINICAL PERIODONTOLOGY 27.1(2000):69-73.|