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学科主题: 口腔医学
题名:
Leukocyte functions in 2 cases of Papillon-Lefevre syndrome
作者: Liu, RK; Cao, CF; Meng, HX; Tang, ZH
关键词: Papillon-Lefevre syndrome ; polymorphonuclear leukocyte chemotaxis ; monocytes ; interleukin-8 ; elastase
刊名: JOURNAL OF CLINICAL PERIODONTOLOGY
发表日期: 2000
卷: 27, 期:1, 页:69-73
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: EARLY-ONSET PERIODONTITIS ; NEUTROPHIL-ACTIVATING FACTOR ; GINGIVAL CREVICULAR FLUID ; GRANULOCYTE ELASTASE ; MOLECULAR-BASIS ; DYSFUNCTION ; CHEMOTAXIS ; RECEPTOR ; SIBLINGS ; PROTEIN
英文摘要:

Aim: To investigate the role of leukocytes in the pathogenesis of Papillon-Lefevre syndrome (PLS).

Methods: Peripheral blood polymorphonuclear neutrophils (PMNs), monocytes (MNs) and gingival crevicular fluid (GCF) were obtained from 2 cases of PLS with typical features. The chemotaxis of PMNs and MNs were evaluated using a modified Boyden chamber. The adherence of PMNs was determined by adherence of PMNs to petri dishes. Interleukin-8 (IL-8) in GCF was detected by sandwich ELISA. Elastase activity in GCF was measured with a low molecular weight substrate (S-2484) specific for granulocyte elastase.

Results: PMNs from both patients showed depressed chemotactic response to FMLP and IL-8. Total amounts of IL-8 in GCF from the 2 patients were much higher than those of the normal controls. Elastase activity was not significantly different from that of the controls. The adherence of PMN and the chemotaxis of MN in the 2 patients were normal.

Conclusion: The depressed chemotactic response of PMN leads to decreased recruitment of PMN and/or release of lysozyme from PMN in the diseased gingival tissue, increasing the susceptibility of PLS patients to periodontal infection.

语种: 英语
WOS记录号: WOS:000084576700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51082
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: Beijing Med Univ, Sch Stomatol, Dept Periodontol, Beijing 100081, Peoples R China

Recommended Citation:
Liu, RK,Cao, CF,Meng, HX,et al. Leukocyte functions in 2 cases of Papillon-Lefevre syndrome[J]. JOURNAL OF CLINICAL PERIODONTOLOGY,2000,27(1):69-73.
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