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学科主题: 口腔医学
题名:
Disruption of Smad4 in odontoblasts and dental epithelial cells influences the phenotype of multiple keratocystic odontogenic tumors
作者: Jiang, Weipeng1,2,4; Yang, Guan2; Chen, Feng3; Yang, Xiao2; Li, Tiejun1
关键词: Keratocystic odontogenic tumors ; Knockout mouse ; Smad4 ; Hh signaling pathway
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2015-07-31
DOI: 10.1016/j.bbrc.2015.05.051
卷: 463, 期:3, 页:280-284
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: BENIGN CYSTIC NEOPLASM ; AGGRESSIVE NATURE ; FIBROBLASTS ; EXPRESSION ; CANCER ; IDENTIFICATION ; MUTATION ; STROMA ; MICE
英文摘要:

Keratocystic odontogenic tumors (KCOTs) are cystic epithelial neoplasms with a high recurrence rate. The molecular mechanisms underlying the initiation and progression of KCOTs are still largely unknown. Previous research showed that specific ablation of Smad4 in odontoblasts and dental epithelia resulted in spontaneous KCOTs in mice, and that constitutively activated Hedgehog (Hh) signaling was detected in the cyst epithelia of both Smad4(Co/Co) OC-Cre and Smad4(Co/Co) K5-Cre mice. Here, we ablated Smad4 in mouse odontoblasts and dental epithelia and compared the sizes and numbers of KCOTs. Both the number and size of KCOTs in Smad4(Co/Co) OC-Cre mice were larger than those in Smad4(Co/Co) K5-Cre mice, suggesting that paracrine signals from root odontoblasts play a more important role than those from Hertwig′s epithelial root sheath (HERS) cells. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81030018 ; 30872900 ; 81241062 ; 81200762 ; 2012CB966904 ; 20120001110043 ; 011401
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China ; Doctoral Fund of Ministry of Education of China ; Science Foundation of the Third Dental Center, Peking University School and Hospital of Stomatology
WOS记录号: WOS:000356998900020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51086
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Inst Biotechnol, Genet Lab Dev & Dis, State Key Lab Prote, Beijing 100071, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Cent Lab, Beijing 100081, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Dent Ctr 3, Beijing 100083, Peoples R China

Recommended Citation:
Jiang, Weipeng,Yang, Guan,Chen, Feng,et al. Disruption of Smad4 in odontoblasts and dental epithelial cells influences the phenotype of multiple keratocystic odontogenic tumors[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,463(3):280-284.
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