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学科主题口腔医学
Disruption of Smad4 in odontoblasts and dental epithelial cells influences the phenotype of multiple keratocystic odontogenic tumors
Jiang, Weipeng1,2,4; Yang, Guan2; Chen, Feng3; Yang, Xiao2; Li, Tiejun1
关键词Keratocystic Odontogenic Tumors Knockout Mouse Smad4 Hh Signaling Pathway
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2015-07-31
DOI10.1016/j.bbrc.2015.05.051
463期:3页:280-284
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]BENIGN CYSTIC NEOPLASM ; AGGRESSIVE NATURE ; FIBROBLASTS ; EXPRESSION ; CANCER ; IDENTIFICATION ; MUTATION ; STROMA ; MICE
英文摘要

Keratocystic odontogenic tumors (KCOTs) are cystic epithelial neoplasms with a high recurrence rate. The molecular mechanisms underlying the initiation and progression of KCOTs are still largely unknown. Previous research showed that specific ablation of Smad4 in odontoblasts and dental epithelia resulted in spontaneous KCOTs in mice, and that constitutively activated Hedgehog (Hh) signaling was detected in the cyst epithelia of both Smad4(Co/Co) OC-Cre and Smad4(Co/Co) K5-Cre mice. Here, we ablated Smad4 in mouse odontoblasts and dental epithelia and compared the sizes and numbers of KCOTs. Both the number and size of KCOTs in Smad4(Co/Co) OC-Cre mice were larger than those in Smad4(Co/Co) K5-Cre mice, suggesting that paracrine signals from root odontoblasts play a more important role than those from Hertwig′s epithelial root sheath (HERS) cells. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000356998900020
项目编号81030018 ; 30872900 ; 81241062 ; 81200762 ; 2012CB966904 ; 20120001110043 ; 011401
资助机构National Natural Science Foundation of China ; National Basic Research Program of China ; Doctoral Fund of Ministry of Education of China ; Science Foundation of the Third Dental Center, Peking University School and Hospital of Stomatology
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51086
专题北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Inst Biotechnol, Genet Lab Dev & Dis, State Key Lab Prote, Beijing 100071, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Cent Lab, Beijing 100081, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Dent Ctr 3, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Weipeng,Yang, Guan,Chen, Feng,et al. Disruption of Smad4 in odontoblasts and dental epithelial cells influences the phenotype of multiple keratocystic odontogenic tumors[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,463(3):280-284.
APA Jiang, Weipeng,Yang, Guan,Chen, Feng,Yang, Xiao,&Li, Tiejun.(2015).Disruption of Smad4 in odontoblasts and dental epithelial cells influences the phenotype of multiple keratocystic odontogenic tumors.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,463(3),280-284.
MLA Jiang, Weipeng,et al."Disruption of Smad4 in odontoblasts and dental epithelial cells influences the phenotype of multiple keratocystic odontogenic tumors".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 463.3(2015):280-284.
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