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学科主题: 临床医学
题名:
Subclinical Carotid Atherosclerosis: Short-term Natural History of Lipid-rich Necrotic Core-A Multicenter Study with MR Imaging
作者: Sun, Jie1; Balu, Niranjan1; Hippe, Daniel S.1; Xue, Yunjing3; Dong, Li4; Zhao, Xihai5; Li, Feiyu6; Xu, Dongxiang1; Hatsukami, Thomas S.2; Yuan, Chun1
刊名: RADIOLOGY
发表日期: 2013-07-01
DOI: 10.1148/radiol.13121702
卷: 268, 期:1, 页:61-68
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: HIGH-RESOLUTION MRI ; IN-VIVO ; LOWERING THERAPY ; INTRAPLAQUE HEMORRHAGE ; PLAQUE PROGRESSION ; FOLLOW-UP ; CORONARY ATHEROSCLEROSIS ; INTRAVASCULAR ULTRASOUND ; FIBROUS-CAP ; TIME-COURSE
英文摘要:

Purpose: To use magnetic resonance (MR) imaging to examine the short-term (6 months) natural history of the lipid-rich necrotic core (LRNC) in carotid artery plaques by examining the placebo group of a multicenter clinical trial.

Materials and Methods: Study procedures and consent forms were approved by the institutional review board for this HIPAA-compliant study. Written informed consent was obtained for all enrolled subjects. Subjects in the placebo group of a multicenter clinical trial who showed LRNC at screening MR imaging had a follow-up MR imaging examination after 6 months. Lumen and wall volumes and LRNC volume and percentage were measured on images from both examinations by readers who were blinded to the time sequence. Plaque progression was calculated as annualized change in common coverage by using the carotid artery bifurcation as a landmark. Associations of clinical and imaging variables with LRNC progression were examined by using linear regression analysis.

Results: Fifty-nine of 73 (81%) subjects completed the study, with a mean interval +/- standard deviation of 6.9 months +/- 1.0. The mean progression rates per year 6 standard deviation of LRNC volume and percentage were -5.2 mm(3) +/- 34.3 (P = .249) and -1.74% +/- 6.27% (P = .038), respectively. Of the clinical and imaging variables examined, presence of intraplaque hemorrhage (IPH) was significantly associated with LRNC progression (P = .001). Plaques with IPH had increased LRNC volume per year (62.9 mm(3) +/- 46.2 vs -8.8 mm(3) +/- 29.9, P<.001) and percentage per year (3.67% +/- 1.85% vs -2.03% +/- 6.30%, P = .126) compared with those without IPH. Spearman correlation analysis showed that change in LRNC positively correlated with change in wall volume (rho = 0.60, P<.001), but not with change in lumen volume (rho = 20.17, P = .201).

Conclusion: Serial MR imaging of the carotid artery allowed observation of changes in LRNC over a short follow-up period and demonstrated the complexity of plaque progression patterns related to tissue composition. LRNC progression may be influenced not only by clinical characteristics, but also and to a large extent by plaque characteristics such as IPH. (C) RSNA, 2013

语种: 英语
项目资助者: Kowa Research Institute ; VP Diagnostics ; Philips Healthcare
WOS记录号: WOS:000320761400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51096
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Union Hosp, Dept Radiol, Fuzhou, Peoples R China
2.Anzhen Hosp, Dept Radiol, Beijing, Peoples R China
3.Univ Washington, Dept Radiol, Seattle, WA 98109 USA
4.Univ Washington, Dept Surg, Seattle, WA 98109 USA
5.Tsinghua Univ, Sch Med, Ctr Biomed Imaging Res, Beijing 100084, Peoples R China
6.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Jie,Balu, Niranjan,Hippe, Daniel S.,et al. Subclinical Carotid Atherosclerosis: Short-term Natural History of Lipid-rich Necrotic Core-A Multicenter Study with MR Imaging[J]. RADIOLOGY,2013,268(1):61-68.
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