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学科主题临床医学
Association between KCNJ11 gene polymorphisms and risk of type 2 diabetes mellitus in East Asian populations: a meta-analysis in 42,573 individuals
Yang, Lijuan; Zhou, Xianghai; Luo, Yingying; Sun, Xiuqin; Tang, Yong; Guo, Wulan; Han, Xueyao; Ji, Linong
关键词Kcnj11 Polymorphisms Type 2 Diabetes Mellitus Meta-analysis Association
刊名MOLECULAR BIOLOGY REPORTS
2012
DOI10.1007/s11033-011-0782-6
39期:1页:645-659
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]GENOME-WIDE ASSOCIATION ; SENSITIVE POTASSIUM CHANNELS ; K-ATP CHANNELS ; SINGLE NUCLEOTIDE POLYMORPHISM ; JAPANESE POPULATION ; CUMULATIVE METAANALYSIS ; SULFONYLUREA RECEPTOR ; INSULIN-RESPONSE ; PUBLICATION BIAS ; CLINICAL-TRIALS
英文摘要

A number of studies have been performed to identify the association between potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene and type 2 diabetes mellitus (T2DM) in East Asian populations, with inconsistent results. The main aim of this work was to evaluate more precisely the genetic influence of KCNJ11 on T2DM in East Asian populations by means of a meta-analysis. We identified 20 articles for qualitative analysis and 16 were eligible for quantitative analysis (meta-analysis) by database searching up to May 2010. The association was assessed under different genetic models, and the pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. The allelic and genotypic contrast demonstrated that the association between KCNJ11 and T2DM was significant for rs5210. However, not all results for rs5215 and rs5218 showed significant associations. For rs5219, the combined ORs (95% CIs) for allelic contrast, dominant and recessive models contrast (with allelic frequency and genotypic distribution data) were 1.139 (1.093-1.188), 1.177 (1.099-1.259) and 1.207 (1.094-1.332), respectively (random effect model). The analysis on the most completely adjusted ORs (95% CIs) by the covariates of rs5219 all presented significant associations under different genetic models. Population-stratified analysis (Korean, Japanese and Chinese) and sensitivity analysis verified the significant results. Cumulative meta-analysis including publication time and sample size illustrated the exaggerated genetic effect in the earliest studies. Heterogeneity and publication bias were assessed. Our study verified that single nucleotide polymorphisms (SNPs) of KCNJ11 gene were significantly associated with the risk of T2DM in East Asian populations.

语种英语
WOS记录号WOS:000297355700081
项目编号2006CB503900 ; 2006AA02A409
资助机构National Basic Research Program of China (973 program) ; National High Technology Research and Development Program of China (863 program)
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51099
专题北京大学第二临床医学院
北京大学第二临床医学院_内分泌科
作者单位Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Yang, Lijuan,Zhou, Xianghai,Luo, Yingying,et al. Association between KCNJ11 gene polymorphisms and risk of type 2 diabetes mellitus in East Asian populations: a meta-analysis in 42,573 individuals[J]. MOLECULAR BIOLOGY REPORTS,2012,39(1):645-659.
APA Yang, Lijuan.,Zhou, Xianghai.,Luo, Yingying.,Sun, Xiuqin.,Tang, Yong.,...&Ji, Linong.(2012).Association between KCNJ11 gene polymorphisms and risk of type 2 diabetes mellitus in East Asian populations: a meta-analysis in 42,573 individuals.MOLECULAR BIOLOGY REPORTS,39(1),645-659.
MLA Yang, Lijuan,et al."Association between KCNJ11 gene polymorphisms and risk of type 2 diabetes mellitus in East Asian populations: a meta-analysis in 42,573 individuals".MOLECULAR BIOLOGY REPORTS 39.1(2012):645-659.
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