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Technetium 99m-Labeled VQ Peptide: A New Imaging Agent for the Early Detection of Tumors or Premalignancies
Shi, Jiyun1; Cui, Liyang1; Jia, Bing1; Liu, Zhaofei1; He, Peng1; Dong, Chengyan1; Jin, Xiaona1; Zhao, Huiyun1; Li, Fang1; Wang, Fan1
刊名MOLECULAR IMAGING
2013-07-01
DOI10.2310/7290.2012.00047
12期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Radiology, Nuclear Medicine & Medical Imaging
资助者Outstanding Youth Fund ; "973" projects ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Education of China ; Outstanding Youth Fund ; "973" projects ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Education of China
研究领域[WOS]Biochemistry & Molecular Biology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]COLORECTAL-CANCER ; IN-VIVO ; FDG-PET ; TC-99M-MIBI ; CELLS ; COLON ; INFLAMMATION ; RESPONSES
英文摘要

There is a critical need to develop diagnostic procedures enabling early detection of tumors while at a curable stage. Technetium 99m (Tc-99m)-labeled VQ peptide (Tc-99m-HYNIC-VQ) identified through screening phage display peptide libraries against fresh human colonic adenomas was prepared and evaluated for tumor detection. Tc-99m-HYNIC-VQ was prepared by a non-SnCl2 method with more than 99% radiochemical purity. The biodistribution in the HT-29 tumor model showed that although the absolute tumor uptake values were relatively low (0.60 +/- 0.09, 0.41 +/- 0.09, 0.36 +/- 0.18, and 0.19 +/- 0.08 %ID/g at 0.5, 1, 2, and 4 hours postinjection, respectively), the tumor uptake was higher than that of any of the other organs except for the kidneys at any time point examined, which led to the high tumor to nontarget ratios. The tumors and inflammation were clearly visualized with high contrast. Although the mechanism of accumulation of radiolabeled VQ peptide in tumors and inflammation needs to be further investigated, Tc-99m-HYNIC-VQ is a promising imaging agent for the early detection of tumors or premalignancies, at least for screening patients with a high risk of developing cancers.

语种英语
所属项目编号81125011 ; 2011CB707703 ; 2013CB733802 ; 81000625 ; 30930030 ; 81222019 ; 30900373 ; 81201127 ; 81028009 ; 2011YQ030114 ; 2012ZX09102301-018 ; 2012BAK25B03-16 ; 31300 ; BMU20110263
资助者Outstanding Youth Fund ; "973" projects ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Education of China ; Outstanding Youth Fund ; "973" projects ; National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology of China ; Ministry of Education of China
WOS记录号WOS:000336724400004
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51101
专题北京大学医药卫生分析中心
作者单位1.Peking Univ, Med Isotopes Res Ctr, Med & Hlth Analyt Ctr, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Radiat Med, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Dept Nucl Med, Med Coll Hosp, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Shi, Jiyun,Cui, Liyang,Jia, Bing,et al. Technetium 99m-Labeled VQ Peptide: A New Imaging Agent for the Early Detection of Tumors or Premalignancies[J]. MOLECULAR IMAGING,2013,12(5).
APA Shi, Jiyun.,Cui, Liyang.,Jia, Bing.,Liu, Zhaofei.,He, Peng.,...&Wang, Fan.(2013).Technetium 99m-Labeled VQ Peptide: A New Imaging Agent for the Early Detection of Tumors or Premalignancies.MOLECULAR IMAGING,12(5).
MLA Shi, Jiyun,et al."Technetium 99m-Labeled VQ Peptide: A New Imaging Agent for the Early Detection of Tumors or Premalignancies".MOLECULAR IMAGING 12.5(2013).
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