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Study of STAT3 G-quadruplex folding patterns by CD spectroscopy and molecular modeling
Lin, Sen2; Xu, Ming1; Yuan, Gu2
关键词G-quadruplex Stat3 Gene Cd Spectroscopy Molecular Modeling
刊名CHINESE CHEMICAL LETTERS
2012-03-01
DOI10.1016/j.cclet.2011.11.002
23期:3页:329-331
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
资助者National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Program for New Century Excellent Talents in University ; Beijing Talents Foundation ; Beijing National Laboratory for Molecular Sciences ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Program for New Century Excellent Talents in University ; Beijing Talents Foundation ; Beijing National Laboratory for Molecular Sciences
研究领域[WOS]Chemistry
关键词[WOS]HEART
英文摘要

The G-quadruplexes formed from G-rich strands in the telomere and oncogene-promoter regions are regarded as new promising targets in the cancer therapy. A G-quadruplex in the downstream flanking region of the signal transducer and activator of transcription 3 (STAT3) gene was explored. Its folding patterns were proposed to be 3:2:2 and 3:3:1 loop isomers by the mutation analysis by CD spectroscopy. The structures were constructed and refined by molecular modeling method. (C) 2012 Gu Yuan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种英语
所属项目编号90913004 ; 30821001 ; 7082101
资助者National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Program for New Century Excellent Talents in University ; Beijing Talents Foundation ; Beijing National Laboratory for Molecular Sciences ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Program for New Century Excellent Talents in University ; Beijing Talents Foundation ; Beijing National Laboratory for Molecular Sciences
WOS记录号WOS:000301631500020
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51103
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Minist Educ, Key Lab Mol Cardiovasc Sci,Inst Vasc Med, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn, Minist Educ,Dept Chem Biol,BNLMS, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Lin, Sen,Xu, Ming,Yuan, Gu. Study of STAT3 G-quadruplex folding patterns by CD spectroscopy and molecular modeling[J]. CHINESE CHEMICAL LETTERS,2012,23(3):329-331.
APA Lin, Sen,Xu, Ming,&Yuan, Gu.(2012).Study of STAT3 G-quadruplex folding patterns by CD spectroscopy and molecular modeling.CHINESE CHEMICAL LETTERS,23(3),329-331.
MLA Lin, Sen,et al."Study of STAT3 G-quadruplex folding patterns by CD spectroscopy and molecular modeling".CHINESE CHEMICAL LETTERS 23.3(2012):329-331.
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