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学科主题: 临床医学
题名:
Study of STAT3 G-quadruplex folding patterns by CD spectroscopy and molecular modeling
作者: Lin, Sen2; Xu, Ming1; Yuan, Gu2
关键词: G-quadruplex ; STAT3 gene ; CD spectroscopy ; Molecular modeling
刊名: CHINESE CHEMICAL LETTERS
发表日期: 2012-03-01
DOI: 10.1016/j.cclet.2011.11.002
卷: 23, 期:3, 页:329-331
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: HEART
英文摘要:

The G-quadruplexes formed from G-rich strands in the telomere and oncogene-promoter regions are regarded as new promising targets in the cancer therapy. A G-quadruplex in the downstream flanking region of the signal transducer and activator of transcription 3 (STAT3) gene was explored. Its folding patterns were proposed to be 3:2:2 and 3:3:1 loop isomers by the mutation analysis by CD spectroscopy. The structures were constructed and refined by molecular modeling method. (C) 2012 Gu Yuan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种: 英语
所属项目编号: 90913004 ; 30821001 ; 7082101
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Program for New Century Excellent Talents in University ; Beijing Talents Foundation ; Beijing National Laboratory for Molecular Sciences
WOS记录号: WOS:000301631500020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51103
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Minist Educ, Key Lab Mol Cardiovasc Sci,Inst Vasc Med, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn, Minist Educ,Dept Chem Biol,BNLMS, Beijing 100871, Peoples R China

Recommended Citation:
Lin, Sen,Xu, Ming,Yuan, Gu. Study of STAT3 G-quadruplex folding patterns by CD spectroscopy and molecular modeling[J]. CHINESE CHEMICAL LETTERS,2012,23(3):329-331.
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