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Class IV-G and IV-S lupus nephritis in Chinese patients: a large cohort study from a single center
Yu, F.1; Tan, Y.1; Wu, L. H.1; Zhu, S-N2; Liu, G.1; Zhao, M-H1
关键词Class Iv-g Class Iv-s Lupus Nephritis
刊名LUPUS
2009-10-01
DOI10.1177/0961203309106795
18期:12页:1073-1081
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; ANTI-C1Q ANTIBODIES ; INTRAVENOUS CYCLOPHOSPHAMIDE ; MYCOPHENOLATE-MOFETIL ; INDUCTION TREATMENT ; ERYTHEMATOSUS ; GLOMERULONEPHRITIS ; CLASSIFICATION ; DEPOSITION ; PROGNOSIS
英文摘要

This study is to assess the difference between IV-G and IV-S in a large cohort of Chinese patients with lupus nephritis. The detailed data of patients with subclass IV-G and IV-S were retrospectively analyzed. Serum ANCA and anti-C1q antibodies were detected. A total of 172 cases were classified as class IV, including 152 cases with IV-G and 20 cases with IV-S. In IV-S, the level of haemoglobin was significantly higher (P = 0.024), proteinuria was milder (P = 0.003), serum creatinine was lower (P = 0.021), serum C3 was higher (P = 0.045) and the ratio of positive serum anticardiolipin antibodies was higher (P = 0.014). On pathological evaluation, the ratio of glomerular fibrinoid necrosis was significantly higher (P = 0.006) and the score of endocapillary hypercellualrity, interstitial inflammation and total activity indices was significantly lower (P < 0.001, P = 0.01, P = 0.006, respectively) in IV-S. The frequency of serum ANCA was significantly higher in IV-S than that in IV-G (20 vs 4.6%, P = 0.008). The frequencies of anti-C1q IgG1 and IgG3 subclass were significantly higher in IV-G (P = 0.006, P = 0.011, respectively). There are significant differences in clinical and pathological manifestations between IV-S and IV-G lupus nephritis which need further investigation. Lupus (2009) 18, 1073-1081.

语种英语
WOS记录号WOS:000269864000008
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51112
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Div Renal, Dept Med, Hosp 1,Inst Nephrol,Key Lab Renal Dis,Minist Hlth, Beijing 100034, Peoples R China
2.Peking Univ, Dept Biostat, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yu, F.,Tan, Y.,Wu, L. H.,et al. Class IV-G and IV-S lupus nephritis in Chinese patients: a large cohort study from a single center[J]. LUPUS,2009,18(12):1073-1081.
APA Yu, F.,Tan, Y.,Wu, L. H.,Zhu, S-N,Liu, G.,&Zhao, M-H.(2009).Class IV-G and IV-S lupus nephritis in Chinese patients: a large cohort study from a single center.LUPUS,18(12),1073-1081.
MLA Yu, F.,et al."Class IV-G and IV-S lupus nephritis in Chinese patients: a large cohort study from a single center".LUPUS 18.12(2009):1073-1081.
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