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学科主题: 临床医学
题名:
Early experiences on living donor liver transplantation in China: multicenter report
作者: Wang, XH1; Yan, LN1; Zhang, F1; Li, XC1; Zhu, JY1; Peng, ZH1; Liu, JH1; Li, GQ1; Cheng, F1; Sun, BC1; Ge, WG1
关键词: liver transplantation ; living donors ; liver failure
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2006-06-20
卷: 119, 期:12, 页:1003-1009
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: SINGLE-CENTER EXPERIENCE/ ; WILSONS-DISEASE ; ADULT ; CHILDREN ; RECIPIENTS ; SELECTION
英文摘要:

Background Because of the lack of brain death laws in China, the proportion of cadaveric organ donation is low. Many patients with end-stage liver disease die waiting for a suitable donor. Living donor liver transplantation (LDLT) would reduce the current discrepancy between the number of patients on the transplant waiting list and the number of available organ donors. We describe the early experience of LDLT in the mainland of China based on data from five liver transplant centers.

Methods Between January 2001 and October 2003, 45 patients with end-stage liver disease received LDLT at five centers in China. The indication and timing, surgical techniques and complications, nonsurgical issues including rejection, infection, and advantages of LDLT in the series were reviewed. Actuarial patient and graft survival rates were calculated by using the Kaplan-Meier product-limit estimate. Statistical analysis was completed by using SPSS 10.0.

Results All LDLT recipients were cirrhotic patients, except for one man with fulminant hepatic failure. Among the 45 cases of LDLT, 35 (77.8%) were performed in one center (the First Affiliated Hospital of Nanjing Medical University). The overall 1 and 3 year survival rate of the recipients was 93.1 % and 92.0%, respectively. Of the 45 LDLT donors, there were 3 cases of biliary leakage, 2 subphrenic collections, 1 fat liquefaction around the incision and I biliary peritonitis after T tube removal. All donors recovered completely.

Conclusions LDLT provides an excellent approach to addressing the problem of donor shortage in China even though the operation is complicated, uncompromising and difficult with respect to the safety of the donors and receptors. Despite early technical hurdles having been overcome, perfection of technique is still necessarily. At present, LDLT is a good choice for the patients with irreversible liver disease.

语种: 英语
WOS记录号: WOS:000238634900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51116
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

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作者单位: 1.Nanjing Med Univ, Affiliated Hosp 1, Liver Transplantat Ctr, Nanjing 210029, Peoples R China
2.Sichuan Univ, W China Hosp, Dept Hepatobiliary Surg, Chengdu 610041, Peoples R China
3.Peking Univ, Hosp 1, Dept Hepatobiliary Surg, Beijing 100035, Peoples R China
4.Shanghai Jiao Tong Univ, Peoples Hosp 1, Dept Hepatobiliary Surg, Shanghai 200080, Peoples R China
5.Hebei Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Shijiazhuang 050000, Peoples R China

Recommended Citation:
Wang, XH,Yan, LN,Zhang, F,et al. Early experiences on living donor liver transplantation in China: multicenter report[J]. CHINESE MEDICAL JOURNAL,2006,119(12):1003-1009.
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