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学科主题: 临床医学
题名:
Reduced white matter integrity and cognitive deficit in never-medicated chronic schizophrenia: A diffusion tensor study using TBSS
作者: Liu, Xiaoyi1; Lai, Yunyao1; Wang, Xijin2; Hao, Chuanxi1; Chen, Lei1; Zhou, Zhenyu1; Yu, Xin2; Hong, Nan1
关键词: Schizophrenia ; Never-medicated ; Diffusion tensor imaging ; White matter ; Cognitive ability
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2013-09-01
DOI: 10.1016/j.bbr.2013.05.061
卷: 252, 页:157-163
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: INFERIOR LONGITUDINAL FASCICULUS ; VOXEL-BASED MORPHOMETRY ; HUMAN BRAIN ; FRACTIONAL ANISOTROPY ; RADIAL DIFFUSIVITY ; CORPUS-CALLOSUM ; WORKING-MEMORY ; ANTERIOR LIMB ; 1ST-EPISODE SCHIZOPHRENIA ; ONSET SCHIZOPHRENIA
英文摘要:

Background: Disrupted white matter (WM) integrity is the pathological hallmark of schizophrenia. Previous studies have reported the cognitive deficits that are associated with WM disruption in schizophrenia with anti-psychiatric treatment. However, no study has yet revealed the correlation between cognition and WM abnormalities in never-medicated chronic schizophrenia.

Methods: We used the diffusion tensor imaging (DTI) with tract-based spatial statistics (TBSS) approach to investigate the whole-brain difference in the WM fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) values between 17 schizophrenia patients and 17 healthy controls matched in age, gender and education level. Patients′ cognition was assessed through the MATRICS Consensus Cognitive Battery (MCCB). We explored the association between WM reduction and cognitive, clinical characteristics (severity of clinical symptoms, age, age of onset, illness duration).

Results: Voxel-wise statistics revealed that schizophrenia patients showed significant FA reduction in left inferior longitudinal fasciculus (ILF) and left inferior fronto-occipital fasciculus (IFOF), and no difference in MD, AD or RD as compared to healthy subjects. Furthermore, in the patients group, lower FA value of the left ILF and left IFOF significantly correlated with worse processing speed, as well as verbal learning and visual learning abilities. There was no correlation between the FA value and the severity of clinical symptoms, age, and age of onset or illness duration.

Conclusion: Our results provide evidence to support that the disconnection of WM pathways may contribute to the pathophysiology of schizophrenia and suggest that the disturbance of left ILF and left IFOF integrity may contribute to cognitive deficits in schizophrenia, independent of effects of antipsychotic medication. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2007BAI17B04 ; RDC2012-04
项目资助者: National Key Technologies R &amp ; D Program of China ; Peking University People&prime ; s Hospital Research and Development Fund
WOS记录号: WOS:000324153600020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51122
Appears in Collections:北京大学第二临床医学院_放射科_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Xiaoyi,Lai, Yunyao,Wang, Xijin,et al. Reduced white matter integrity and cognitive deficit in never-medicated chronic schizophrenia: A diffusion tensor study using TBSS[J]. BEHAVIOURAL BRAIN RESEARCH,2013,252:157-163.
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