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学科主题: 临床医学
题名:
Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats.
作者: Mei, S1; Yao, W1; Zhu, YJ1; Zhao, JY1
刊名: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
发表日期: 2005-04-01
DOI: 10.1124/jpet.104.078030
卷: 313, 期:1, 页:379-388
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TUMOR-NECROSIS-FACTOR ; RESPIRATORY-DISTRESS-SYNDROME ; BLEOMYCIN-HAMSTER MODEL ; PULMONARY INFLAMMATION ; SUPEROXIDE-PRODUCTION ; ENDOTHELIAL-CELLS ; OXIDATIVE STRESS ; FACTOR-ALPHA ; FIBROSIS ; INHIBITION
英文摘要:

The potential role of PFD [5-methyl-L-phenyl-2-(1H)-pyridone], an antifibrotic compound with anti-inflammatory effects, in several models of acute lung injury (ALI) has gained increasing attention; however, the protective effect of PFD in oleic acid (OA)-induced ALI remains unknown. We hypothesized that PFD protects from OA-induced ALI in rats, and we hoped to obtain the optimum preclinical conditions with PFD in ALI. Sprague-Dawley rats were randomized into five groups (five rats per group): normal control group, OA-treated group (0.15 ml/kg), and three PFD-treated groups (20, 40, and 80 mg/kg p.o., respectively). Arterial blood gases, lung wet/dry weight ratio, and postmortem histological changes were determined 0.5, 1, 2, 6, and 24 h after OA challenge. Electron spin resonance spectroscopy was used for free radical detection and measurement. Experiments were examined based on the orthogonal test L4 (4(2)) setting two factors (PFD dose and PFD valid time) with four different levels. The results of the orthogonal test showed that the sequence of effect of PFD was 0.5 h (oxygen radicals), 1 h (histological changes), 2 h (lung edema), and 6 h (partial pressure of oxygen) after OA challenge, and 40 mg/kg PFD was the most effective dose in this study. We conclude that PFD protects against OA-induced ALI in rats. The mechanism of these protective effects partly involves decrease of oxygen radicals. The data of this study proves that the orthogonal test will be a powerful method to help obtain the optimum experimental conditions with PFD in ALI in the future.

语种: 英语
WOS记录号: WOS:000227733000044
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51127
Appears in Collections:北京大学第三临床医学院_职业病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Res Ctr Occupat Med, Beijing 100083, Peoples R China
2.Beijing Union Med Coll Hosp, Dept Resp Med, Beijing, Peoples R China

Recommended Citation:
Mei, S,Yao, W,Zhu, YJ,et al. Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats.[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,2005,313(1):379-388.
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