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IR@PKUHSC  > 北京大学临床肿瘤学院  > 遗传学研究室  > 期刊论文
学科主题: 临床医学
题名:
HLA polymorphisms are associated with Helicobacter pylori infected gastric cancer in a high risk population, China
作者: Li, ZH1; Chen, DF1; Zhang, CF1; Li, Y1; Cao, BW1; Ning, T1; Zhao, YM1; You, WC1; Ke, Y1
关键词: human leukocyte antigen ; polymorphism ; Helicobacter pylori ; genetic susceptibility ; gastric cancer
刊名: IMMUNOGENETICS
发表日期: 2005-02-01
DOI: 10.1007/s00251-004-0723-9
卷: 56, 期:11, 页:781-787
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Immunology
研究领域[WOS]: Genetics & Heredity ; Immunology
关键词[WOS]: GENETIC SUSCEPTIBILITY ; CARCINOMA ; ADENOCARCINOMA ; LESIONS ; DISEASE ; DQ
英文摘要:

Helicobacter pylori is one of the most common bacterial infections associated with an increased risk of gastric cancer, but its association with host factors, particularly polymorphisms of the immune response genes, such as human leukocyte antigen (HLA) genes, is still unclear. To investigate the role of HLA polymorphisms in the risk of gastric cancer among subjects with H. pylori infection, a case-control study involving 52 gastric cancer patients and 139 non-cancer controls was conducted in Linqu County, China, an area with a high incidence of gastric cancer. Polymorphisms of HLA class I and class II alleles were determined by PCR with sequence-specific primers (PCRSSP). The information about H. pylori infection was obtained from previous records. Among 48 class I and 19 class II HLA alleles detected in this study, two alleles, CW*03 and DRB1*01, were found to be distributed significantly differently between patients and controls [ odds ratio(OR) = 1.95, 95% confidence interval (CI) = 1.13 - 3.35, P = 0.017 and OR = 4.39, 95% CI = 1.39 - 13.84, P = 0.012, respectively). The OR of gastric cancer risk in individuals carrying CW*03/CW*03 or CW*03/CW*N was 2.06, 95% CI = 1.05 - 4.02, P = 0.035, while the OR was 3.49, 95% CI = 1.0 - 12.4, P = 0.04 for DRB1*01/DRB1*01 or DRB1*01/DRB1*N carriers. The analysis of the interaction between H. pylori infection and HLA risk genotypes of CW*03 or DRB1*01 revealed that the effect of CW*03 and DRB1*01 genotypes on gastric cancer risk was manifested stronger in H. pylori-positive individuals ( OR = 5.30, 95% CI = 1.73 - 16.29, P = 0.004 and OR = 13.38, 95% CI = 2.52 - 70.98, P = 0.002, respectively) than in H. pylori-negative ones (OR = 1.25, 95% CI = 0.25 - 6.12, P = 0.785 and OR = 2.26, 95% CI = 0.18 - 28.88, P = 0.531, respectively). The combined effect of the two risk HLA genotypes on gastric cancer risk was also analysed. The result showed that the individuals carrying both the CW*03 and DRB1*01 alleles could only be found in cancer patients (5/52), and not in controls (0/139), further suggesting that CW*03 and DRB1*01 are risk alleles advancing the progression of tumorigenesis. These observations demonstrate that host HLA genotypes may play an important role in the risk of gastric cancer, especially among persons with H. pylori infection.

语种: 英语
WOS记录号: WOS:000227047300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51131
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing, Peoples R China
2.Peking Univ, Dept Genet, Sch Oncol, Beijing Inst Canc Res, Beijing 100034, Peoples R China
3.Shandong Univ, Dept Gen Surg, Qilu Hosp, Jinan 250100, Peoples R China
4.Peking Univ, Dept Cell Biol & Genet, Beijing 100871, Peoples R China
5.Peking Univ, Dept Clin Epidemiol, Affiliated Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Li, ZH,Chen, DF,Zhang, CF,et al. HLA polymorphisms are associated with Helicobacter pylori infected gastric cancer in a high risk population, China[J]. IMMUNOGENETICS,2005,56(11):781-787.
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