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学科主题: 药学
题名:
New Efficient and Flexible Synthetic Route to Emivirine and Its Analogs
作者: Li, Li1; Ma, Liying2; Wang, Xiaowei1; Liu, Junyi1,3
刊名: JOURNAL OF HETEROCYCLIC CHEMISTRY
发表日期: 2013
DOI: 10.1002/jhet.987
卷: 50, 期:1, 页:164-168
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: POTENT ; HEPT
英文摘要:

A revised synthetic route to Emivirine (MKC-442) via properly substituted beta-keto ester converted from Meldrum′s Acid was developed. This method could be applied to the synthesis of a variety of MKC-442 analogues and open the way for their systematic biological evaluation.

语种: 英语
所属项目编号: 20672008 ; 20972011 ; 2005CB523103
项目资助者: National Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000314187100027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51140
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent NCAIDS, Beijing 100050, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drug, Beijing 100191, Peoples R China

Recommended Citation:
Li, Li,Ma, Liying,Wang, Xiaowei,et al. New Efficient and Flexible Synthetic Route to Emivirine and Its Analogs[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2013,50(1):164-168.
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