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学科主题: 临床医学
题名:
Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma
作者: Hou, Xue1,2,3; Wu, Xuan4; Huang, Peiyu2,3,5; Zhan, Jianhua2,3; Zhou, Ting1,2,3; Ma, Yuxiang2,3,6; Qin, Tao1,2,3; Luo, Rongzhen2,3,7; Feng, Yanfen2,3,7; Xu, Ying8; Chen, Likun1,2,3; Zhang, Li1,2,3
关键词: nasopharyngeal neoplasms ; osteopontin ; bone sialoprotein ; bone metastasis ; prognosis
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2015-10-01
DOI: 10.1002/ijc.29540
卷: 137, 期:7, 页:1672-1678
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: BREAST-CANCER ; PROSTATE-CANCER ; TUMOR-METASTASIS ; CELL MIGRATION ; LUNG-CANCER ; IN-VITRO ; EXPRESSION ; SIALOPROTEIN ; INTEGRIN ; GROWTH
英文摘要:

Bone is the most common metastatic site in nasopharyngeal carcinoma (NPC). Osteopontin (OPN) and bone sialoprotein (BSP) are demonstrated to be involved in multiple steps of distant metastasis and correlate with bone metastasis (BM) in cancers. We aim to explore the impacts of OPN and BSP on the prognosis of the patients with locally advanced NPC. A tissue microarray including 162 locally advanced NPC specimens was generated for immunohistochemical evaluation. All of the patients received curative treatment. Twenty-two patients developed BM during follow-up. The OPN expression level was higher in patients with BM than in those without BM (p=0.005), whereas no significant difference of the BSP expression level was noted (p=0.634). Univariate analysis demonstrated that a higher level of OPN expression associated with a poorer 8-year metastasis-free survival (MFS) rate (p<0.001), 8-year bone metastasis-free survival (BMFS) rate (93.6 vs. 87.5 vs. 64.5% for immunoreactivity score 1, 2 and 3, respectively; p=0.001) and median overall survival (OS) time (p<0.001). Multivariate Cox analysis confirmed that high level of OPN expression was independent factor associated with decreased BMFS (p=0.02), MFS (p<0.001) and OS (p<0.001). Our findings indicate that OPN is a prognostic biomarker for BM and survival in patients with locally advanced NPC, and therefore it is useful in identifying the patients with an increased risk of cancer progression and BM to guide tailored therapy.

What′s new? Nasalpharyngeal carcinoma frequently metastasizes to the bones. These authors sought a way to identify which patients are most likely to get bone metastases? They found that patients with bone metastasis also had high levels of osteopontin, an integrin-binding glycophosphoprotein which has been shown in previous work to help cancer cells infiltrate the bone. Patients with lots of osteopontin also had shorter metastasis-free survival, suggesting that testing for it could help clinicians target and treat those patients most likely to suffer metastases.

语种: 英语
所属项目编号: 2012B031800280 ; 2012AA02A502 ; 04140601
项目资助者: Guangdong Provincial Science and Technology Planning Foundation ; National High Technology Research and Development Program of China ; Excellent Young Talent Project of Sun Yat-sen University Cancer Center
WOS记录号: WOS:000358012600015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51143
Appears in Collections:北京大学深圳医院_肿瘤内科_期刊论文

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作者单位: 1.Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China
2.State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China
3.Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Oncol, Shenzhen, Guangdong, Peoples R China
5.Sun Yat Sen Univ, Ctr Canc, Dept Nasopharyngeal Carcinoma, Guangzhou 510060, Guangdong, Peoples R China
6.Sun Yat Sen Univ, Ctr Canc, Dept Clin Res, Guangzhou 510060, Guangdong, Peoples R China
7.Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou 510060, Guangdong, Peoples R China
8.Sun Yat Sen Univ, Inst Med Stat & Epidemiol, Guangzhou 510060, Guangdong, Peoples R China

Recommended Citation:
Hou, Xue,Wu, Xuan,Huang, Peiyu,et al. Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma[J]. INTERNATIONAL JOURNAL OF CANCER,2015,137(7):1672-1678.
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