| 学科主题 | 药学 |
| A new insulin-enhancing agent: [N,N ′-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity | |
| Xie, Ming-jin1; Li, Ling2; Yang, Xiao-Da3; Liu, Wei-ping4; Yan, Shi-ping5; Niu, Yan-fen2; Meng, Zhao-hui6 | |
| 关键词 | Insulin-enhancing Salen-type Ligands Caco-2 Cells |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 2010-06-01 | |
| DOI | 10.1016/j.ejmech.2010.02.010 |
| 卷 | 45期:6页:2327-2335 |
| 收录类别 | SCI ; IC |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Chemistry, Medicinal |
| 资助者 | National Natural Science Foundation of China ; Yunnan Natural Science Foundation ; Yunnan University Science Foundation ; National Natural Science Foundation of China ; Yunnan Natural Science Foundation ; Yunnan University Science Foundation |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | DEPENDENT DIABETES-MELLITUS ; VANADIUM COMPOUNDS ; CRYSTAL-STRUCTURE ; GLUCOSE-HOMEOSTASIS ; MIMETIC AGENT ; IN-VIVO ; RATS ; COMPLEXES ; SULFATE ; BIS(MALTOLATO)OXOVANADIUM(IV) |
| 英文摘要 | A new insulin-enhancing agent: [N,N′-bis(4-hydroxysalicylidene)-o-phenylene-diamine] oxovanadium (IV) (BPOV) was synthesized and characterized by X-ray crystallography. BPOV was administered intragastrically to STZ-diabetic rats for 4 weeks. The results showed that BPOV could significantly decrease the blood glucose level and ameliorated impaired glucose tolerance in STZ-diabetic rats. BPOV has been further tested on insulin, glycogen and serum lipid studies. The results suggested BPOV has glucose-lowering activity in diabetic rats, as well as improved the disorder of lipid metabolism in diabetes. BPOV had permeability above 10(-5) cm s(-1). It was suggested good lipophilic properties. The cytotoxicity of BPOV on Caco-2 cells was measured by MTT assay which suggested BPOV have higher effect on impairment of cellular associated with lower level capacity of cellular accumulation. |
| 语种 | 英语 |
| 所属项目编号 | 30260118 ; 2002C0019R ; 2009CD006 ; 2005Q002A |
| 资助者 | National Natural Science Foundation of China ; Yunnan Natural Science Foundation ; Yunnan University Science Foundation ; National Natural Science Foundation of China ; Yunnan Natural Science Foundation ; Yunnan University Science Foundation |
| WOS记录号 | WOS:000278056000028 |
| Citation statistics | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/51144 |
| Collection | 北京大学药学院_化学生物学系 |
| 作者单位 | 1.Yunnan Univ, Dept Chem, Kunming 650091, Yunnan, Peoples R China 2.Kunming Inst Precious Met, Kunming 650221, Peoples R China 3.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China 4.Kunming Hosp Populat & Hlth, Kunming 650204, Peoples R China 5.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Peoples R China 6.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China |
| Recommended Citation GB/T 7714 | Xie, Ming-jin,Li, Ling,Yang, Xiao-Da,et al. A new insulin-enhancing agent: [N,N ′-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2010,45(6):2327-2335. |
| APA | Xie, Ming-jin.,Li, Ling.,Yang, Xiao-Da.,Liu, Wei-ping.,Yan, Shi-ping.,...&Meng, Zhao-hui.(2010).A new insulin-enhancing agent: [N,N ′-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,45(6),2327-2335. |
| MLA | Xie, Ming-jin,et al."A new insulin-enhancing agent: [N,N ′-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 45.6(2010):2327-2335. |
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