A new insulin-enhancing agent: [N,N′-bis(4-hydroxysalicylidene)-o-phenylene-diamine] oxovanadium (IV) (BPOV) was synthesized and characterized by X-ray crystallography. BPOV was administered intragastrically to STZ-diabetic rats for 4 weeks. The results showed that BPOV could significantly decrease the blood glucose level and ameliorated impaired glucose tolerance in STZ-diabetic rats. BPOV has been further tested on insulin, glycogen and serum lipid studies. The results suggested BPOV has glucose-lowering activity in diabetic rats, as well as improved the disorder of lipid metabolism in diabetes. BPOV had permeability above 10(-5) cm s(-1). It was suggested good lipophilic properties. The cytotoxicity of BPOV on Caco-2 cells was measured by MTT assay which suggested BPOV have higher effect on impairment of cellular associated with lower level capacity of cellular accumulation.
1.Yunnan Univ, Dept Chem, Kunming 650091, Yunnan, Peoples R China 2.Kunming Inst Precious Met, Kunming 650221, Peoples R China 3.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China 4.Kunming Hosp Populat & Hlth, Kunming 650204, Peoples R China 5.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Peoples R China 6.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
Recommended Citation:
Xie, Ming-jin,Li, Ling,Yang, Xiao-Da,et al. A new insulin-enhancing agent: [N,N ′-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2010,45(6):2327-2335.
