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学科主题: 药学
题名:
A new insulin-enhancing agent: [N,N ′-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity
作者: Xie, Ming-jin1; Li, Ling2; Yang, Xiao-Da3; Liu, Wei-ping4; Yan, Shi-ping5; Niu, Yan-fen2; Meng, Zhao-hui6
关键词: Insulin-enhancing ; Salen-type ligands ; Caco-2 cells
刊名: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
发表日期: 2010-06-01
DOI: 10.1016/j.ejmech.2010.02.010
卷: 45, 期:6, 页:2327-2335
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DEPENDENT DIABETES-MELLITUS ; VANADIUM COMPOUNDS ; CRYSTAL-STRUCTURE ; GLUCOSE-HOMEOSTASIS ; MIMETIC AGENT ; IN-VIVO ; RATS ; COMPLEXES ; SULFATE ; BIS(MALTOLATO)OXOVANADIUM(IV)
英文摘要:

A new insulin-enhancing agent: [N,N′-bis(4-hydroxysalicylidene)-o-phenylene-diamine] oxovanadium (IV) (BPOV) was synthesized and characterized by X-ray crystallography. BPOV was administered intragastrically to STZ-diabetic rats for 4 weeks. The results showed that BPOV could significantly decrease the blood glucose level and ameliorated impaired glucose tolerance in STZ-diabetic rats. BPOV has been further tested on insulin, glycogen and serum lipid studies. The results suggested BPOV has glucose-lowering activity in diabetic rats, as well as improved the disorder of lipid metabolism in diabetes. BPOV had permeability above 10(-5) cm s(-1). It was suggested good lipophilic properties. The cytotoxicity of BPOV on Caco-2 cells was measured by MTT assay which suggested BPOV have higher effect on impairment of cellular associated with lower level capacity of cellular accumulation.

语种: 英语
所属项目编号: 30260118 ; 2002C0019R ; 2009CD006 ; 2005Q002A
项目资助者: National Natural Science Foundation of China ; Yunnan Natural Science Foundation ; Yunnan University Science Foundation
WOS记录号: WOS:000278056000028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51144
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Yunnan Univ, Dept Chem, Kunming 650091, Yunnan, Peoples R China
2.Kunming Inst Precious Met, Kunming 650221, Peoples R China
3.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
4.Kunming Hosp Populat & Hlth, Kunming 650204, Peoples R China
5.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Peoples R China
6.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Xie, Ming-jin,Li, Ling,Yang, Xiao-Da,et al. A new insulin-enhancing agent: [N,N ′-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2010,45(6):2327-2335.
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