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IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions
作者: Li, Hui-jie1; Wang, Peng-yun1,2; Jiang, Yang3; Chan, Raymond C. K.4; Wang, Hua-li5; Li, Juan1
关键词: Mild cognitive impairment ; Neurological soft signs ; Neuropsychological tests
刊名: BEHAVIORAL AND BRAIN FUNCTIONS
发表日期: 2012-06-07
DOI: 10.1186/1744-9081-8-29
卷: 8
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: INCIDENT ALZHEIMER-DISEASE ; NEUROCOGNITIVE FUNCTIONS ; PREFRONTAL CORTEX ; SCHIZOPHRENIA ; ABNORMALITIES ; INDIVIDUALS ; DYSFUNCTION ; INHIBITION ; INVENTORY ; DEFICITS
英文摘要:

Background: Neurological abnormalities have been reported in people with amnestic mild cognitive impairment (aMCI). The current study aimed to examine the prevalence of neurological soft signs (NSS) in this clinical group and to examine the relationship of NSS to other neuropsychological performances.

Methods: Twenty-nine people with aMCI and 28 cognitively healthy elderly people were recruited for the present study. The NSS subscales (motor coordination, sensory integration, and disinhibition) of the Cambridge Neurological Inventory and a set of neuropsychological tests were administered to all the participants.

Results: People with aMCI exhibited significantly more motor coordination signs, disinhibition signs, and total NSS than normal controls. Correlation analysis showed that the motor coordination subscale score and total score of NSS were significantly inversely correlated with the combined Z-score of neuropsychological tests in aMCI group.

Conclusions: These preliminary findings suggested that people with aMCI demonstrated a higher prevalence of NSS compared to healthy elderly people. Moreover, NSS was found to be inversely correlated with the neuropsychological performances in persons with aMCI. When taken together, these findings suggested that NSS may play a potential important role and serve as a tool to assist in the early detection of aMCI.

语种: 英语
所属项目编号: 30770725 ; 31000465 ; 30911120494 ; 2009BAI77B03 ; KSCX2-YW-R-256 ; KSCX2-EW-J-8 ; 81088001
项目资助者: National Natural Science Foundation of China ; National Science &amp ; Technology Pillar Program of China ; Knowledge Innovation Project of the Chinese Academy of Sciences ; National Outstanding Young Investigator Award from National Science Foundation of China
WOS记录号: WOS:000311727100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51145
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
3.Univ Kentucky, Coll Med, Dept Behav Sci, Lexington, KY 40536 USA
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
5.Peking Univ, Inst Mental Hlth, Dept Geriatr Psychiat, Beijing 100871, Peoples R China

Recommended Citation:
Li, Hui-jie,Wang, Peng-yun,Jiang, Yang,et al. Neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2012,8.
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