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Neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions
Li, Hui-jie1; Wang, Peng-yun1,2; Jiang, Yang3; Chan, Raymond C. K.4; Wang, Hua-li5; Li, Juan1
关键词Mild Cognitive Impairment Neurological Soft Signs Neuropsychological Tests
刊名BEHAVIORAL AND BRAIN FUNCTIONS
2012-06-07
DOI10.1186/1744-9081-8-29
8
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]INCIDENT ALZHEIMER-DISEASE ; NEUROCOGNITIVE FUNCTIONS ; PREFRONTAL CORTEX ; SCHIZOPHRENIA ; ABNORMALITIES ; INDIVIDUALS ; DYSFUNCTION ; INHIBITION ; INVENTORY ; DEFICITS
英文摘要

Background: Neurological abnormalities have been reported in people with amnestic mild cognitive impairment (aMCI). The current study aimed to examine the prevalence of neurological soft signs (NSS) in this clinical group and to examine the relationship of NSS to other neuropsychological performances.

Methods: Twenty-nine people with aMCI and 28 cognitively healthy elderly people were recruited for the present study. The NSS subscales (motor coordination, sensory integration, and disinhibition) of the Cambridge Neurological Inventory and a set of neuropsychological tests were administered to all the participants.

Results: People with aMCI exhibited significantly more motor coordination signs, disinhibition signs, and total NSS than normal controls. Correlation analysis showed that the motor coordination subscale score and total score of NSS were significantly inversely correlated with the combined Z-score of neuropsychological tests in aMCI group.

Conclusions: These preliminary findings suggested that people with aMCI demonstrated a higher prevalence of NSS compared to healthy elderly people. Moreover, NSS was found to be inversely correlated with the neuropsychological performances in persons with aMCI. When taken together, these findings suggested that NSS may play a potential important role and serve as a tool to assist in the early detection of aMCI.

语种英语
WOS记录号WOS:000311727100001
项目编号30770725 ; 31000465 ; 30911120494 ; 2009BAI77B03 ; KSCX2-YW-R-256 ; KSCX2-EW-J-8 ; 81088001
资助机构National Natural Science Foundation of China ; National Science &amp ; Technology Pillar Program of China ; Knowledge Innovation Project of the Chinese Academy of Sciences ; National Outstanding Young Investigator Award from National Science Foundation of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51145
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
3.Univ Kentucky, Coll Med, Dept Behav Sci, Lexington, KY 40536 USA
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
5.Peking Univ, Inst Mental Hlth, Dept Geriatr Psychiat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Hui-jie,Wang, Peng-yun,Jiang, Yang,et al. Neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2012,8.
APA Li, Hui-jie,Wang, Peng-yun,Jiang, Yang,Chan, Raymond C. K.,Wang, Hua-li,&Li, Juan.(2012).Neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions.BEHAVIORAL AND BRAIN FUNCTIONS,8.
MLA Li, Hui-jie,et al."Neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions".BEHAVIORAL AND BRAIN FUNCTIONS 8(2012).
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