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学科主题临床医学
In Vitro Immunological Effects of Blocking CCR5 on T Cells
Yuan, Jing; Ren, Han-yun; Shi, Yong-jin; Liu, Wei
关键词t Cell Activation Blocking Ccr5 Chemotaxis Cross Talk
刊名INFLAMMATION
2015-04-01
DOI10.1007/s10753-014-0052-6
38期:2页:902-910
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]VERSUS-HOST-DISEASE ; INHIBITOR MARAVIROC ; HIV ; TRANSPLANTATION ; INFLAMMATION ; EXPRESSION ; INFECTION ; RESPONSES ; BIOLOGY
英文摘要

Blockade of CC chemokine receptor 5 (CCR5) by maraviroc may induce immunological changes independent of its antiviral effects and may have immunoregulation properties. This study was designed to determine the effects of blocking CCR5 on human activated T cells in vitro and investigate the potential immunological mechanisms. Human CD3+ T cells were purified from peripheral blood mononuclear cells and then activated by cytokines. We tested the surface expressions and relative messenger RNA (mRNA) levels of CCR2, CCR5, CCR6, CCR7, and CXCR3, chemotaxis toward their cognate ligands, internalization of chemokine receptors, and production of cytokines. In conclusion, blocking CCR5 by maraviroc not only can block CCR5 and CCR2 internalization processes induced by CCL5 and CCL2, but also inhibit T cell chemotactic activities toward their cognate ligands, respectively. Moreover, blocking CCR5 with maraviroc at high doses tends to decrease the production of TNF-alpha and IFN-gamma. In addition, there might be a form of cross talk between CCR5 and CCR2, and this may offer a novel immunological effect for blockade of CCR5.

语种英语
所属项目编号81370667
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000350553800048
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51155
专题北京大学第一临床医学院_血液内科
作者单位Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yuan, Jing,Ren, Han-yun,Shi, Yong-jin,et al. In Vitro Immunological Effects of Blocking CCR5 on T Cells[J]. INFLAMMATION,2015,38(2):902-910.
APA Yuan, Jing,Ren, Han-yun,Shi, Yong-jin,&Liu, Wei.(2015).In Vitro Immunological Effects of Blocking CCR5 on T Cells.INFLAMMATION,38(2),902-910.
MLA Yuan, Jing,et al."In Vitro Immunological Effects of Blocking CCR5 on T Cells".INFLAMMATION 38.2(2015):902-910.
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