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学科主题临床医学
Ghrelin inhibits proinflammatory responses and nuclear factor-kappa B activation in human endothelial cells
Li, WG1; Gavrila, D1; Liu, XB1; Wang, LX1; Gunnlaugsson, S1; Stoll, LL1; McCormick, ML1; Sigmund, CD1; Tang, CS1; Weintraub, NL1
关键词Inflammation Hormones Endotoxins Peptide Monocytes Nuclear Factor-kappa b
刊名CIRCULATION
2004-05-11
DOI10.1161/01.CIR.0000127956.43874.F2
109期:18页:2221-2226
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]RECEPTOR ; RATS ; SECRETION ; OBESITY
英文摘要

Background-Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone secretagogue receptor has been identified in blood vessels, we examined whether ghrelin inhibits proinflammatory responses in human endothelial cells in vitro and after administration of endotoxin to rats in vivo.

Methods and Results-Human umbilical vein endothelial cells (HUVECs) were treated with or without tumor necrosis factor-alpha(TNF-alpha), and induction of proinflammatory cytokines and mononuclear cell adhesion were determined. Ghrelin (0.1 to 1000 ng/mL) inhibited both basal and TNF-alpha-induced cytokine release and mononuclear cell binding. Intravenous administration of ghrelin also inhibited endotoxin-induced proinflammatory cytokine production in rats in vivo. Ghrelin inhibited H2O2-induced cytokine release in HUVECs, suggesting that the peptide blocks redox-mediated cellular signaling. Moreover, ghrelin inhibited basal and TNF-alpha-induced activation of nuclear factor-kappaB. Des-acyl ghrelin had no effect on TNF-alpha-induced cytokine production in HUVECs, suggesting that the antiinflammatory effects of ghrelin require interaction with endothelial growth hormone secretagogue receptors.

Conclusions-Ghrelin inhibits proinflammatory cytokine production, mononuclear cell binding, and nuclear factor-kappaB activation in human endothelial cells in vitro and endotoxin-induced cytokine production in vivo. These novel antiinflammatory actions of ghrelin suggest that the peptide could play a modulatory role in atherosclerosis, especially in obese patients, in whom ghrelin levels are reduced.

语种英语
WOS记录号WOS:000221322600013
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被引频次:348[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51159
专题北京大学第一临床医学院_心血管内科
作者单位1.Univ Iowa, Coll Med, Dept Internal Med, Div Cardiovasc, Iowa City, IA 52242 USA
2.Univ Iowa, Dept Surg, Iowa City, IA 52242 USA
3.Univ Iowa, Free Rad & Radiat Biol Program, Iowa City, IA 52242 USA
4.Vet Affairs Med Ctr, Iowa City, IA 52242 USA
5.Peking Univ, Hosp 1, Inst Cardiovasc Dis Res, Beijing 100871, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, WG,Gavrila, D,Liu, XB,et al. Ghrelin inhibits proinflammatory responses and nuclear factor-kappa B activation in human endothelial cells[J]. CIRCULATION,2004,109(18):2221-2226.
APA Li, WG.,Gavrila, D.,Liu, XB.,Wang, LX.,Gunnlaugsson, S.,...&Weintraub, NL.(2004).Ghrelin inhibits proinflammatory responses and nuclear factor-kappa B activation in human endothelial cells.CIRCULATION,109(18),2221-2226.
MLA Li, WG,et al."Ghrelin inhibits proinflammatory responses and nuclear factor-kappa B activation in human endothelial cells".CIRCULATION 109.18(2004):2221-2226.
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