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学科主题: 基础医学
题名:
Structure Elucidation and Immunomodulatory Activity of A Beta Glucan from the Fruiting Bodies of Ganoderma Sinense
作者: Han, Xiao-Qiang1,2; Yue, Gar-Lee1; Yue, Rui-Qi3; Dong, Cai-Xia3; Chan, Chung-Lap1; Ko, Chun-Hay1; Cheung, Wing-Shing1; Luo, Ke-Wang1; Dai, Hui4; Wong, Chun-Kwok1; Leung, Ping-Chung1; Han, Quan-Bin1,3
刊名: PLOS ONE
发表日期: 2014-07-11
DOI: 10.1371/journal.pone.0100380
卷: 9, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: EDIBLE MUSHROOM ; PLEUROTUS-FLORIDA ; B-CELLS ; POLYSACCHARIDE ; MACROPHAGES ; ANTITUMOR ; IMMUNITY ; LUCIDUM ; CULTURE ; EDODES
英文摘要:

A polysaccharide named GSP-2 with a molecular size of 32 kDa was isolated from the fruiting bodies of Ganoderma sinense. Its structure was well elucidated, by a combined utilization of chemical and spectroscopic techniques, to be a beta-glucan with a backbone of (1 -> 4)- and (1 -> 6)-Glcp, bearing terminal- and (1 -> 3)-Glcp side-chains at O-3 position of (1 -> 6)-Glcp. Immunological assay exhibited that GSP-2 significantly induced the proliferation of BALB/c mice splenocytes with target on only B cells, and enhanced the production of several cytokines in human peripheral blood mononuclear cells and derived dendritic cells. Besides, the fluorescent labeled GSP-2 was phagocytosed by the RAW 264.7 cells and induced the nitric oxide secretion from the cells.

语种: 英语
所属项目编号: ITS/311/09 ; InP/108/10 ; 81303210 ; 81102253 ; FRG2/11-12/048 ; FRG1/12-13/018 ; FRG2/12-13/006
项目资助者: Innovation and Technology Fund of the Government of the Hong Kong Special Administrative Region ; National Natural Science Foundation of China ; Hong Kong Baptist University
WOS记录号: WOS:000339378400008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51161
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Inst Chinese Med, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Guangdong, Peoples R China
3.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Immunol, Beijing 100871, Peoples R China

Recommended Citation:
Han, Xiao-Qiang,Yue, Gar-Lee,Yue, Rui-Qi,et al. Structure Elucidation and Immunomodulatory Activity of A Beta Glucan from the Fruiting Bodies of Ganoderma Sinense[J]. PLOS ONE,2014,9(7).
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