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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
The cell composition of infused donor lymphocyte has different impact in different types of allogeneic hematopoietic stem cell transplantation
作者: Zhao, Xiao-su1,2; Wang, Yu1,2; Yan, Chen-hua1,2; Wang, Jing-zhi1,2; Zhang, Xiao-hui1,2; Xu, Lan-ping1,2; Liu, Kai-yan1,2; Huang, Xiao-jun1,2,3
关键词: composition ; donor lymphocyte infusion ; allogeneic hematopoietic stem cell transplantation ; outcome ; graft-versus-host disease
刊名: CLINICAL TRANSPLANTATION
发表日期: 2014-08-01
DOI: 10.1111/ctr.12404
卷: 28, 期:8, 页:926-934
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery ; Transplantation
研究领域[WOS]: Surgery ; Transplantation
关键词[WOS]: VERSUS-HOST-DISEASE ; UNMANIPULATED HAPLOIDENTICAL BLOOD ; NATURAL-KILLER-CELLS ; SUPPRESSOR-CELLS ; PERIPHERAL-BLOOD ; HEPATOCELLULAR-CARCINOMA ; MARROW TRANSPLANTATION ; PLATELET ENGRAFTMENT ; PEDIATRIC-PATIENTS ; CLINICAL-OUTCOMES
英文摘要:

Donor lymphocyte infusion (DLI) is often used to enhance the graft-versus-leukemia (GVL) effect after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, we first evaluated the impact of the cell composition of a modified DLI (mDLI) on the prognoses of patients. A total of 194 patients undergoing allo-HSCT were enrolled and received mDLI for various clinical reasons. The infused cellular components of the mDLI were examined by flow cytometry. The results showed that infusion with a lower dose of CD14+ cells (<0.33x108/kg) was an independent risk factor for the occurrence of II-IV acute graft-versus-host disease (aGVHD) (HR=0.104, p=0.032) in human leukoctye antigen-identical transplant patients. In addition, a dose of CD14+ cells greater than the 50th percentile was associated with a lower incidence of hematological relapse and longer disease-free survival (DFS) after the mDLI (relapse: HR=0.193, p=0.007; DFS: HR=0.259, p=0.016). However, we also found that a greater number of CD14+ cells were an independent risk factor for II-IV aGVHD (HR=1.758, p=0.034) in haploidentical allo-HSCT. In conclusion, our data were the first to demonstrate that the cell composition of a 56 mDLI played a distinct role in different types of allo-HSCT. This finding provided a novel approach for the development of cellular therapies by manipulating the components of infused cells.

语种: 英语
所属项目编号: 81230013 ; Z121107001012085 ; 2011-4022-08
项目资助者: Key Program of National Natural Science Foundation of China ; Clinical Characteristic Study of Capital Project ; Scientific Research Foundation for Capital Medicine Development ; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation
WOS记录号: WOS:000340474100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51166
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
3.Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China

Recommended Citation:
Zhao, Xiao-su,Wang, Yu,Yan, Chen-hua,et al. The cell composition of infused donor lymphocyte has different impact in different types of allogeneic hematopoietic stem cell transplantation[J]. CLINICAL TRANSPLANTATION,2014,28(8):926-934.
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