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学科主题: 临床医学
题名:
Factors associated with post-pancreaticoduodenectomy hemorrhage: 303 consecutive cases analysis
作者: Gao Qing-xiang1; Lee Hua-yu1; Wu Wen-han1; Gao Song1; Yang Yin-mo1; Ma Irene Teting2; Cai Meng-shan1
关键词: pancreaticoduodenectomy ; post-operative bleeding ; surgical procedures
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-05-05
DOI: 10.3760/cma.j.issn.0366-6999.2012.09.009
卷: 125, 期:9, 页:1571-1575
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INTERNATIONAL STUDY-GROUP ; RISK-FACTORS ; ARTERIAL HEMORRHAGE ; POSTPANCREATECTOMY HEMORRHAGE ; PANCREATIC LEAKAGE ; SENTINEL BLEED ; MANAGEMENT ; COMPLICATIONS ; SURGERY ; DEFINITION
英文摘要:

Background Because of the complexity and severity of the surgery and its associated complications, pancreaticoduodenectomy (PD) is associated with significant morbidity and mortality, especially the hemorrhage post-PD. Exploring the factors associated with post-PD hemorrhage is very important for the patients′ safety.

Methods Clinical data from 303 cases of PD between January 1998 and December 2008 were analyzed retrospectively.

Results The overall mortality rate was 4.95% (15/303). However, post-operative bleeding occurred in 25 patients (8.25%) with nine episodes resulting in death (36.00%). Univariate analysis was performed and identified tumor size, Child′s classification, total pancreatic uncinatic process resection, and pancreatic leakage as significant risk factors for post-PD hemorrhage. In the severe hemorrhage group, incomplete resection of uncinate process of pancreas and pancreatic leakage were the main causes. The multivariate Logistic regression analysis revealed that each of these variables is an independent risk factor.

Conclusions Primary prevention of bleeding complications depends on total pancreatic uncinatic process resection and meticulous hemostatic techniques during surgery. In addition, several pen-operative factors were found to contribute to post-PD bleeding. Chin Med J 2012;125(9):1571-1575

语种: 英语
项目资助者: Department of Surgery, Peking University First Hospital
WOS记录号: WOS:000304022500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51169
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

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作者单位: 1.Univ New Mexico, Albuquerque, NM 87131 USA
2.Peking Univ First Hosp, Dept Surg, Beijing 100034, Peoples R China

Recommended Citation:
Gao Qing-xiang,Lee Hua-yu,Wu Wen-han,et al. Factors associated with post-pancreaticoduodenectomy hemorrhage: 303 consecutive cases analysis[J]. CHINESE MEDICAL JOURNAL,2012,125(9):1571-1575.
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