IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
First-Line Therapy for Chronic Graft-versus-Host Disease that Includes Low-Dose Methotrexate Is Associated with a High Response Rate
Wang, Yu; Xu, Lan-ping; Liu, Dai-hong; Chen, Huan; Chen, Yu-hong; Han, Wei; Liu, Kai-yan; Huang, Xiao-jun
关键词Hematopoietic Stem Cell Transplantation Allogeneic Methotrexate Chronic Graft-versus-host Disease
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2009-04-01
DOI10.1016/j.bbmt.2008.12.493
15期:4页:505-511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
资助者National Outstanding Young Scientist&prime ; s Foundation of China ; FE-tech Research and Development Program of China ; Program for Innovative Research Team in University ; National Outstanding Young Scientist&prime ; s Foundation of China ; FE-tech Research and Development Program of China ; Program for Innovative Research Team in University
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]STEM-CELL TRANSPLANTATION ; MARROW TRANSPLANTATION ; SALVAGE THERAPY ; CYCLOSPORINE ; PROPHYLAXIS ; THALIDOMIDE ; MECHANISMS ; TACROLIMUS
英文摘要

We report the results of low-dose methotrexate (MTX) as first-line therapy mostly in combination with other immunosuppressive agents in patients with chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Between November 2001 and March 2008,86 patients with cGVHD after allo-HSCT received low-dose MTX therapy until a complete or partial response (CR, PR) was achieved, or until treatment failure or intolerable side effects were found. The median time from HSCT to the start of MTX was 154 (range: 80-993) days. The median number of MTX administrations was 4 (range: 2-18). The overall response rate among all enrolled patients was 83% (71 of 86 patients). The response rate for GVHD involving various organs was 90% (45 of 50) in the skin, 75% (39 of 52) in the liver, 42% (5 of 12) in the mouth, 3 of 7 in the eye, and 2 of 2 in the gut. In addition, MTX treatment allowed for a significant reduction in the prednisone dosage (median 90%) from 20 (2.5-100) mg at the start of MTX administration to 5 (0-30) mg 1 month after MTX was last used. Multivariate analysis showed that the only significant factor related to higher CR rate was sole organ involvement (P = .007). Grade 3 toxicities occurred in only 3 patients presenting cytopenias or oral mucositis. From this analysis, MTX appears to be a well-toletated, effective, and inexpensive agent when used as a first-line treatment in combination with other immunosuppressive agents for cGVHD, especially for skin or sole organ involvement without concomitant thrombocytopenia.

语种英语
所属项目编号30725038 ; 2006AA02Z4A0 ; IRT 0702
资助者National Outstanding Young Scientist&prime ; s Foundation of China ; FE-tech Research and Development Program of China ; Program for Innovative Research Team in University ; National Outstanding Young Scientist&prime ; s Foundation of China ; FE-tech Research and Development Program of China ; Program for Innovative Research Team in University
WOS记录号WOS:000264616000014
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51170
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yu,Xu, Lan-ping,Liu, Dai-hong,et al. First-Line Therapy for Chronic Graft-versus-Host Disease that Includes Low-Dose Methotrexate Is Associated with a High Response Rate[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2009,15(4):505-511.
APA Wang, Yu.,Xu, Lan-ping.,Liu, Dai-hong.,Chen, Huan.,Chen, Yu-hong.,...&Huang, Xiao-jun.(2009).First-Line Therapy for Chronic Graft-versus-Host Disease that Includes Low-Dose Methotrexate Is Associated with a High Response Rate.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,15(4),505-511.
MLA Wang, Yu,et al."First-Line Therapy for Chronic Graft-versus-Host Disease that Includes Low-Dose Methotrexate Is Associated with a High Response Rate".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 15.4(2009):505-511.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yu]的文章
[Xu, Lan-ping]的文章
[Liu, Dai-hong]的文章
百度学术
百度学术中相似的文章
[Wang, Yu]的文章
[Xu, Lan-ping]的文章
[Liu, Dai-hong]的文章
必应学术
必应学术中相似的文章
[Wang, Yu]的文章
[Xu, Lan-ping]的文章
[Liu, Dai-hong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。