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Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases
Zhang Le1; Wang Juan1; Li Bin1; Gao Bowen1; Wang Xiaohui1; Shi Shepo1; Tu Pengfei1
关键词Plant Polyketide Synthases Unnatural Small Molecules Combinatorial Synthesis Combinatorial Biosynthesis
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
2013-12-01
DOI10.6023/cjoc201307012
33期:12页:2469-2484
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]ENGINEERED ESCHERICHIA-COLI ; CHAIN-LENGTH CONTROL ; HUMULUS-LUPULUS L. ; CHALCONE SYNTHASE ; COMBINATORIAL BIOSYNTHESIS ; ACTIVE-SITE ; SUBSTRATE-SPECIFICITY ; BENZOPHENONE SYNTHASE ; PENTAKETIDE CHROMONE ; ENZYMATIC FORMATION
英文摘要

Plant polyketide synthases (PKSs) catalyze iterative decarboxylative condensations of malonyl units (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce linear chain polyketide intermediates. By Claisen, aldol cyclization, or lactonization, and aromatization, the linear chain polyketide intermediates produce varied unnatural small molecules. In this review, the functions of the known plant PKSs are summarized, and the catalytic mechanisms and applications of plant PKSs in the synthesis of unnatural small molecules are covered.

语种中文
WOS记录号WOS:000329686800003
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51178
专题北京大学药学院
北京大学医学部管理机构_医学部
北京大学药学院_天然药物学系
北京大学临床肿瘤学院_图书馆
作者单位1.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang Le,Wang Juan,Li Bin,et al. Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2013,33(12):2469-2484.
APA Zhang Le.,Wang Juan.,Li Bin.,Gao Bowen.,Wang Xiaohui.,...&Tu Pengfei.(2013).Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases.CHINESE JOURNAL OF ORGANIC CHEMISTRY,33(12),2469-2484.
MLA Zhang Le,et al."Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases".CHINESE JOURNAL OF ORGANIC CHEMISTRY 33.12(2013):2469-2484.
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