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学科主题: 药学
题名:
Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases
作者: Zhang Le1; Wang Juan1; Li Bin1; Gao Bowen1; Wang Xiaohui1; Shi Shepo1; Tu Pengfei1
关键词: plant polyketide synthases ; unnatural small molecules ; combinatorial synthesis ; combinatorial biosynthesis
刊名: CHINESE JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2013-12-01
DOI: 10.6023/cjoc201307012
卷: 33, 期:12, 页:2469-2484
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ENGINEERED ESCHERICHIA-COLI ; CHAIN-LENGTH CONTROL ; HUMULUS-LUPULUS L. ; CHALCONE SYNTHASE ; COMBINATORIAL BIOSYNTHESIS ; ACTIVE-SITE ; SUBSTRATE-SPECIFICITY ; BENZOPHENONE SYNTHASE ; PENTAKETIDE CHROMONE ; ENZYMATIC FORMATION
英文摘要:

Plant polyketide synthases (PKSs) catalyze iterative decarboxylative condensations of malonyl units (Claisen-type C-C bond formation) with a CoA-linked starter molecule to produce linear chain polyketide intermediates. By Claisen, aldol cyclization, or lactonization, and aromatization, the linear chain polyketide intermediates produce varied unnatural small molecules. In this review, the functions of the known plant PKSs are summarized, and the catalytic mechanisms and applications of plant PKSs in the synthesis of unnatural small molecules are covered.

语种: 中文
所属项目编号: NCET-11-0604 ; 5132022
项目资助者: Trans-Century Training Program Foundation for the Talents of Humanities and Social Science by the State Education Commission ; Natural Science Foundation of Beijing
WOS记录号: WOS:000329686800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51178
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhang Le,Wang Juan,Li Bin,et al. Synthesis of Unnatural Small Molecules by Plant Specific Polyketide Synthases[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2013,33(12):2469-2484.
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