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学科主题口腔医学
Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2
Li, Chen-Shuang1; Tian, Haijun2,3,4; Zou, Min5; Zhao, Ke-Wei6; Li, Yawei3; Lao, Lifeng3; Brochmann, Elsa J.6,7,8; Duarte, M. Eugenia L.9; Daubs, Michael D.10; Zhou, Yan-Heng1; Murray, Samuel S.6,7,8; Wang, Jeffrey C.11
关键词Bone Morphogenetic Proteins-2 Secreted Phosphoprotein 24 Kd Pancreatic Cancer
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2015-10-16
DOI10.1016/j.bbrc.2015.08.124
466期:2页:167-172
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]BONE MORPHOGENETIC PROTEIN-2 ; PROSTATE-CANCER ; TUMOR-GROWTH ; A549 CELLS ; TGF-BETA ; IN-VIVO ; EXPRESSION ; LESIONS ; NOGGIN ; OVEREXPRESSION
英文摘要

The emerging role of bone morphogenetic proteins (BMPs) in the initiation and progression of multiple cancers has drawn great attention in cancer research. In this study, we report that BMP-2 can promote the proliferation of the pancreatic tumor cell line, PANC-1. Secreted phosphoprotein 24 kD (Spp24), a BMP binding protein, did not affect the proliferation of the cells but promoted the apoptosis of the cells in vitro. In a xeneograft tumor model using PANC-1 cells, BMP-2 dramatically promoted tumor growth, while Spp24 not only abolished the effect of BMP-2, but also dramatically induced tumor shrinking when used alone. Activation of Smad1/518 participated in this process as demonstrated by immunohistochemical staining of phosphorylated Smad 1/5/8. We conclude that Spp24 can be developed into a therapeutic agent that could be employed in clinical situations where the inhibition of BMPs and related proteins is advantageous. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000362610800004
项目编号81402229 ; 2013DFB30360 ; 1IPBX000511 ; 1IORX000383
资助机构National Natural Science Foundation of China ; International S&amp ; T Cooperation Program of China ; Research Service of U.S. Department of Veterans Affairs
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51183
专题北京大学口腔医学院_牙周科
作者单位1.Bethune Sch Med, Dept Surg, Shijiazhuang 050000, Peoples R China
2.Natl Inst Traumatol & Orthopaed, Rio De Janeiro, Brazil
3.Univ So Calif, Dept Orthopaed Surg, Los Angeles, CA USA
4.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
5.Second Mil Med Univ, Dept Orthopaed Surg, Changzheng Hosp, Shanghai, Peoples R China
6.Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA USA
7.Xi An Jiao Tong Univ, Sch & Hosp Stomatol, Dept Orthodont, Xian 710049, Peoples R China
8.VA Greater Angeles Healthcare Syst, Res Serv, North Hills, CA USA
9.VA Greater Angeles Healthcare Syst, Geriatr Res Educ & Clin Ctr, North Hills, CA USA
10.Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA
11.Univ Nevada, Sch Med, Dept Surg, Div Orthopaed Surg, Las Vegas, NV 89154 USA
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GB/T 7714
Li, Chen-Shuang,Tian, Haijun,Zou, Min,et al. Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,466(2):167-172.
APA Li, Chen-Shuang.,Tian, Haijun.,Zou, Min.,Zhao, Ke-Wei.,Li, Yawei.,...&Wang, Jeffrey C..(2015).Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,466(2),167-172.
MLA Li, Chen-Shuang,et al."Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 466.2(2015):167-172.
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