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学科主题: 口腔医学
题名:
Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2
作者: Li, Chen-Shuang1; Tian, Haijun2,3,4; Zou, Min5; Zhao, Ke-Wei6; Li, Yawei3; Lao, Lifeng3; Brochmann, Elsa J.6,7,8; Duarte, M. Eugenia L.9; Daubs, Michael D.10; Zhou, Yan-Heng1; Murray, Samuel S.6,7,8; Wang, Jeffrey C.11
关键词: Bone morphogenetic proteins-2 ; Secreted phosphoprotein 24 kD ; Pancreatic cancer
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2015-10-16
DOI: 10.1016/j.bbrc.2015.08.124
卷: 466, 期:2, 页:167-172
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: BONE MORPHOGENETIC PROTEIN-2 ; PROSTATE-CANCER ; TUMOR-GROWTH ; A549 CELLS ; TGF-BETA ; IN-VIVO ; EXPRESSION ; LESIONS ; NOGGIN ; OVEREXPRESSION
英文摘要:

The emerging role of bone morphogenetic proteins (BMPs) in the initiation and progression of multiple cancers has drawn great attention in cancer research. In this study, we report that BMP-2 can promote the proliferation of the pancreatic tumor cell line, PANC-1. Secreted phosphoprotein 24 kD (Spp24), a BMP binding protein, did not affect the proliferation of the cells but promoted the apoptosis of the cells in vitro. In a xeneograft tumor model using PANC-1 cells, BMP-2 dramatically promoted tumor growth, while Spp24 not only abolished the effect of BMP-2, but also dramatically induced tumor shrinking when used alone. Activation of Smad1/518 participated in this process as demonstrated by immunohistochemical staining of phosphorylated Smad 1/5/8. We conclude that Spp24 can be developed into a therapeutic agent that could be employed in clinical situations where the inhibition of BMPs and related proteins is advantageous. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81402229 ; 2013DFB30360 ; 1IPBX000511 ; 1IORX000383
项目资助者: National Natural Science Foundation of China ; International S&amp ; T Cooperation Program of China ; Research Service of U.S. Department of Veterans Affairs
WOS记录号: WOS:000362610800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51183
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Bethune Sch Med, Dept Surg, Shijiazhuang 050000, Peoples R China
2.Natl Inst Traumatol & Orthopaed, Rio De Janeiro, Brazil
3.Univ So Calif, Dept Orthopaed Surg, Los Angeles, CA USA
4.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
5.Second Mil Med Univ, Dept Orthopaed Surg, Changzheng Hosp, Shanghai, Peoples R China
6.Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA USA
7.Xi An Jiao Tong Univ, Sch & Hosp Stomatol, Dept Orthodont, Xian 710049, Peoples R China
8.VA Greater Angeles Healthcare Syst, Res Serv, North Hills, CA USA
9.VA Greater Angeles Healthcare Syst, Geriatr Res Educ & Clin Ctr, North Hills, CA USA
10.Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA
11.Univ Nevada, Sch Med, Dept Surg, Div Orthopaed Surg, Las Vegas, NV 89154 USA

Recommended Citation:
Li, Chen-Shuang,Tian, Haijun,Zou, Min,et al. Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,466(2):167-172.
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