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Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes
Xiang, Yu; Liang, Liang; Wang, Xueqing; Wang, Jiancheng; Zhang, Xuan; Zhang, Qiang
关键词Chlorotoxin Doxorubicin Liposomes Glioma Targeting Delivery
刊名JOURNAL OF CONTROLLED RELEASE
2011-06-30
DOI10.1016/j.jconrel.2011.03.014
152期:3页:402-410
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; DRUG-DELIVERY ; BLOOD-BRAIN ; MOLECULAR-MECHANISMS ; CELL INVASION ; TUMOR-CELLS ; PEPTIDE ; SCORPION ; XENOGRAFTS ; EXPRESSION
英文摘要

The chlorotoxin (CITx). a scorpion-derived peptide, binding to gliomas with high specificity, was firstly applied to establish the CITx-modified doxorubicin (DOX)-loaded liposome delivery system for targeting the brain glioma and improving the anticancer efficacy. In vitro physicochemical characterization of the novel liposome system presented satisfactory size of 100 nm with uniform distribution, high encapsulation efficiency and adequate loading capacity of both fluorescent probe and anticancer drug. It was demonstrated quantitatively by the spectrophotofluorometry and flow cytometry and qualitatively by the confocal microscopy that CITx highly facilitated the uptake of liposomes by three glioma cell lines and one endothelial cell line. In vitro cytotoxicity studies proved that the presence of CITx increased the cytotoxicity against glioma cells and endothelial cells with various levels for different cell lines. In BALB/c mice bearing U87 tumor xenografts, biodistribution of DiR-loaded liposomes by body imaging and anti-glioma pharmacodynamics of DOX-loaded liposomes were investigated. The CITx-modified liposomes showed more accumulation in the subcutaneous and intracranial tumors, higher tumor growth inhibition and lower blood toxicity in the armpit tumor model. The in vitro and in vivo results exhibited good correlation of glioma targeting of the CITx-modified liposomes. Significantly, with the CITx as the targeting ligand, the liposomes might serve as an applicable delivery system for brain glioma therapy or imaging. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000292666500010
项目编号2007CB935800 ; 2009CB930300 ; 2009ZX09310-001 ; 2007AA021811
资助机构National Basic Research Program of China ; State Key Projects ; 863 Project
引用统计
被引频次:72[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51185
专题北京大学药学院
北京大学药学院_药剂学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Xiang, Yu,Liang, Liang,Wang, Xueqing,et al. Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes[J]. JOURNAL OF CONTROLLED RELEASE,2011,152(3):402-410.
APA Xiang, Yu,Liang, Liang,Wang, Xueqing,Wang, Jiancheng,Zhang, Xuan,&Zhang, Qiang.(2011).Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes.JOURNAL OF CONTROLLED RELEASE,152(3),402-410.
MLA Xiang, Yu,et al."Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes".JOURNAL OF CONTROLLED RELEASE 152.3(2011):402-410.
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