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学科主题: 药学
题名:
Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes
作者: Xiang, Yu; Liang, Liang; Wang, Xueqing; Wang, Jiancheng; Zhang, Xuan; Zhang, Qiang
关键词: Chlorotoxin ; Doxorubicin ; Liposomes ; Glioma ; Targeting delivery
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2011-06-30
DOI: 10.1016/j.jconrel.2011.03.014
卷: 152, 期:3, 页:402-410
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; DRUG-DELIVERY ; BLOOD-BRAIN ; MOLECULAR-MECHANISMS ; CELL INVASION ; TUMOR-CELLS ; PEPTIDE ; SCORPION ; XENOGRAFTS ; EXPRESSION
英文摘要:

The chlorotoxin (CITx). a scorpion-derived peptide, binding to gliomas with high specificity, was firstly applied to establish the CITx-modified doxorubicin (DOX)-loaded liposome delivery system for targeting the brain glioma and improving the anticancer efficacy. In vitro physicochemical characterization of the novel liposome system presented satisfactory size of 100 nm with uniform distribution, high encapsulation efficiency and adequate loading capacity of both fluorescent probe and anticancer drug. It was demonstrated quantitatively by the spectrophotofluorometry and flow cytometry and qualitatively by the confocal microscopy that CITx highly facilitated the uptake of liposomes by three glioma cell lines and one endothelial cell line. In vitro cytotoxicity studies proved that the presence of CITx increased the cytotoxicity against glioma cells and endothelial cells with various levels for different cell lines. In BALB/c mice bearing U87 tumor xenografts, biodistribution of DiR-loaded liposomes by body imaging and anti-glioma pharmacodynamics of DOX-loaded liposomes were investigated. The CITx-modified liposomes showed more accumulation in the subcutaneous and intracranial tumors, higher tumor growth inhibition and lower blood toxicity in the armpit tumor model. The in vitro and in vivo results exhibited good correlation of glioma targeting of the CITx-modified liposomes. Significantly, with the CITx as the targeting ligand, the liposomes might serve as an applicable delivery system for brain glioma therapy or imaging. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2007CB935800 ; 2009CB930300 ; 2009ZX09310-001 ; 2007AA021811
项目资助者: National Basic Research Program of China ; State Key Projects ; 863 Project
WOS记录号: WOS:000292666500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51185
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Xiang, Yu,Liang, Liang,Wang, Xueqing,et al. Chloride channel-mediated brain glioma targeting of chlorotoxin-modified doxorubicine-loaded liposomes[J]. JOURNAL OF CONTROLLED RELEASE,2011,152(3):402-410.
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