IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Antileukemic effect of interleukin-7-transduced bone marrow stromal cells in mice following allogeneic T-cell-depleted bone marrow transplantation
Li, AL; Li, C; Feng, YG; Yuan, GH; Wang, GM; Hao, J; Gao, X; Xie, SS
刊名TRANSPLANTATION PROCEEDINGS
2005-06-01
DOI10.1016/j.transproceed.2005.03.088
37期:5页:2297-2299
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Surgery ; Transplantation
研究领域[WOS]Immunology ; Surgery ; Transplantation
英文摘要

Impaired immune reconstitution following allogeneic bone marrow transplantation (BMT) remains a major obstacle to its clinical application. In this study, interleukin (IL)-7-transduced bone marrow stromal cells (MSC-IL7, 1 X 10(6)/mouse) were transfused into lethally irradiated C57BL/6 recipient mice. By day 40 after transplantation, the recipient mice were challenged with the lymphoma cell line EL4. MSC-IL7 cotransplantation protected recipient mice from leukemic mortality (MST > 120 days after BMT vs mean survival time (MST) 70 days in the PBS group) It enhance the PFC count and DTH responses of recipients after transplantation. In conclusion, MSC mediated IL-7 gene therapy and may be a more feasible strategy to restore immune function following allo-TCD-BMT.

语种英语
WOS记录号WOS:000230024800086
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51189
Collection北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Li, AL,Li, C,Feng, YG,et al. Antileukemic effect of interleukin-7-transduced bone marrow stromal cells in mice following allogeneic T-cell-depleted bone marrow transplantation[J]. TRANSPLANTATION PROCEEDINGS,2005,37(5):2297-2299.
APA Li, AL.,Li, C.,Feng, YG.,Yuan, GH.,Wang, GM.,...&Xie, SS.(2005).Antileukemic effect of interleukin-7-transduced bone marrow stromal cells in mice following allogeneic T-cell-depleted bone marrow transplantation.TRANSPLANTATION PROCEEDINGS,37(5),2297-2299.
MLA Li, AL,et al."Antileukemic effect of interleukin-7-transduced bone marrow stromal cells in mice following allogeneic T-cell-depleted bone marrow transplantation".TRANSPLANTATION PROCEEDINGS 37.5(2005):2297-2299.
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