IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
The association between serum uric acid levels, metabolic syndrome and cardiovascular disease in middle aged and elderly Chinese: results from the DYSlipidemia International Study
Tian, Yongfeng1,2; Chen, Kang1; Xie, Zongyan1; Fang, Yuan1; Wang, Haibin1; Nie, Yi1; Hu, Dayi3; Mu, Yiming1
关键词Uric Acid Metabolic Syndrome x Cardiovascular Disease Epidemiology
刊名BMC CARDIOVASCULAR DISORDERS
2015-07-11
DOI10.1186/s12872-015-0059-4
15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]NUTRITION EXAMINATION SURVEY ; ALL-CAUSE MORTALITY ; GENERAL-POPULATION ; RISK-FACTOR ; ATHEROSCLEROSIS RISK ; NATIONAL-HEALTH ; ISCHEMIC-STROKE ; HEART-DISEASE ; COHORT ; PREVALENCE
英文摘要

Background: To explore the association between serum uric acid (SUA) levels, metabolic syndrome (MetS) and cardiovascular disease (CVD) in patients treated with lipid-lowering agents from multiple centers in China.

Method: We investigated 15,478 participants who had been documented with recorded SUA in the DYSlipidemia International Study which included 25,697 patients, aged 45 years old or older, who were treated with lipid-lowering agents from 122 centers between April 2012 and October 2012. Logistic regression analysis was performed to examine the association between SUA levels, MetS and CVD.

Result: After adjusting for multi-variables, hyperuricemia (the highest category of SUA level) showed a significantly higher risk of MetS compared to the lowest category[according to NCEP-ATPIII criteria, odds ratio (OR) 1.51, 95 % confidence interval (CI) (1.30,1.74) in men, OR 2.35 95 % CI (2.00,2.75) in women; and according to IDF criteria, OR 1.40 95 % CI (1.20,1.63) in men, OR 1.65 95 % CI (1.41,1.94) in women]. In addition, elevated SUA concentration was shown to be associated with coronary heart disease (CHD) (OR 1.26 95 % CI (1.09, 1.45) in men, and OR 1.27, 95 % CI (1.07, 1.50) in women) and heart failure (HF) (OR 1.61 95 % CI (1.15, 2.24) in men, and OR 1.91, 95 % CI (1.29, 2.82) in women).

Conclusion: Our research suggested a positive association between SUA levels and MetS in Chinese patients receiving lipid-lowering therapy. Elevated SU levels were positively associated independently of measured confounders to CHD and HF.

语种英语
WOS记录号WOS:000357718300001
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51194
专题北京大学第二临床医学院_心血管内科
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China
2.Third Mil Med Univ, Xinqiao Hosp, Dept Endocrinol, Chongqing 400037, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Tian, Yongfeng,Chen, Kang,Xie, Zongyan,et al. The association between serum uric acid levels, metabolic syndrome and cardiovascular disease in middle aged and elderly Chinese: results from the DYSlipidemia International Study[J]. BMC CARDIOVASCULAR DISORDERS,2015,15.
APA Tian, Yongfeng.,Chen, Kang.,Xie, Zongyan.,Fang, Yuan.,Wang, Haibin.,...&Mu, Yiming.(2015).The association between serum uric acid levels, metabolic syndrome and cardiovascular disease in middle aged and elderly Chinese: results from the DYSlipidemia International Study.BMC CARDIOVASCULAR DISORDERS,15.
MLA Tian, Yongfeng,et al."The association between serum uric acid levels, metabolic syndrome and cardiovascular disease in middle aged and elderly Chinese: results from the DYSlipidemia International Study".BMC CARDIOVASCULAR DISORDERS 15(2015).
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