北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
The association between serum uric acid levels, metabolic syndrome and cardiovascular disease in middle aged and elderly Chinese: results from the DYSlipidemia International Study
作者: Tian, Yongfeng1,2; Chen, Kang1; Xie, Zongyan1; Fang, Yuan1; Wang, Haibin1; Nie, Yi1; Hu, Dayi3; Mu, Yiming1
关键词: Uric acid ; Metabolic syndrome X ; Cardiovascular disease ; Epidemiology
刊名: BMC CARDIOVASCULAR DISORDERS
发表日期: 2015-07-11
DOI: 10.1186/s12872-015-0059-4
卷: 15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: NUTRITION EXAMINATION SURVEY ; ALL-CAUSE MORTALITY ; GENERAL-POPULATION ; RISK-FACTOR ; ATHEROSCLEROSIS RISK ; NATIONAL-HEALTH ; ISCHEMIC-STROKE ; HEART-DISEASE ; COHORT ; PREVALENCE
英文摘要:

Background: To explore the association between serum uric acid (SUA) levels, metabolic syndrome (MetS) and cardiovascular disease (CVD) in patients treated with lipid-lowering agents from multiple centers in China.

Method: We investigated 15,478 participants who had been documented with recorded SUA in the DYSlipidemia International Study which included 25,697 patients, aged 45 years old or older, who were treated with lipid-lowering agents from 122 centers between April 2012 and October 2012. Logistic regression analysis was performed to examine the association between SUA levels, MetS and CVD.

Result: After adjusting for multi-variables, hyperuricemia (the highest category of SUA level) showed a significantly higher risk of MetS compared to the lowest category[according to NCEP-ATPIII criteria, odds ratio (OR) 1.51, 95 % confidence interval (CI) (1.30,1.74) in men, OR 2.35 95 % CI (2.00,2.75) in women; and according to IDF criteria, OR 1.40 95 % CI (1.20,1.63) in men, OR 1.65 95 % CI (1.41,1.94) in women]. In addition, elevated SUA concentration was shown to be associated with coronary heart disease (CHD) (OR 1.26 95 % CI (1.09, 1.45) in men, and OR 1.27, 95 % CI (1.07, 1.50) in women) and heart failure (HF) (OR 1.61 95 % CI (1.15, 2.24) in men, and OR 1.91, 95 % CI (1.29, 2.82) in women).

Conclusion: Our research suggested a positive association between SUA levels and MetS in Chinese patients receiving lipid-lowering therapy. Elevated SU levels were positively associated independently of measured confounders to CHD and HF.

语种: 英语
项目资助者: Merck sharp &amp ; Dohme (China) Co., Ltd.
WOS记录号: WOS:000357718300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51194
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China
2.Third Mil Med Univ, Xinqiao Hosp, Dept Endocrinol, Chongqing 400037, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Tian, Yongfeng,Chen, Kang,Xie, Zongyan,et al. The association between serum uric acid levels, metabolic syndrome and cardiovascular disease in middle aged and elderly Chinese: results from the DYSlipidemia International Study[J]. BMC CARDIOVASCULAR DISORDERS,2015,15.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tian, Yongfeng]'s Articles
[Chen, Kang]'s Articles
[Xie, Zongyan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tian, Yongfeng]‘s Articles
[Chen, Kang]‘s Articles
[Xie, Zongyan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace