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学科主题: 基础医学
题名:
The Late Stage of T Cell Development within Mouse Thymus
作者: Chen, Weifeng
关键词: immunocompetence ; phenothpic differentiation ; post-selection maturation ; thymocyte development
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2004-02-01
卷: 1, 期:1, 页:3-11
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
英文摘要:

After positive selection and lineage commitment, the TCR alpha beta(+)CD4/CD8 SP medullary thymocytes migrate into and reside in thymic medulla, where they undergo an ordered program of late stage of T cell functional maturation and negative selection to delete self- reactive clones by apoptosis. Accomplishment of this final differentiation pathway, a physiological T cell repertoire is formed: T cells acquire immunocompetence to respond to foreign antigens and tolerance to self- antigens, ready for the emigration to homing to the T cell regions of peripheral lymphoid organs and tissues. In this review, emphases are put on introducing the approaches applied in this area and our own observations. Basically, we have analyzed the late stage of medullary thymocyte phenotypic differentiation pathways of both CD4 SP and CD8 SP medullary thymocytes and the concomitant functional maturation pathway, in particular, of CD4 SP thymocytes. It is to provide a standard to compare the functional capacity of the cells at the developmental stages induced by different conditions. The cellular and molecular basis of this differentiation process has been partially described. Cellular & Molecular Immunology. 2004;1(1):3-11.

语种: 英语
WOS记录号: WOS:000208922100002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51196
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Chen, Weifeng. The Late Stage of T Cell Development within Mouse Thymus[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2004,1(1):3-11.
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