IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
The Late Stage of T Cell Development within Mouse Thymus
Chen, Weifeng
关键词immunocompetence phenothpic differentiation post-selection maturation thymocyte development
刊名CELLULAR & MOLECULAR IMMUNOLOGY
2004-02-01
1期:1页:3-11
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
英文摘要

After positive selection and lineage commitment, the TCR alpha beta(+)CD4/CD8 SP medullary thymocytes migrate into and reside in thymic medulla, where they undergo an ordered program of late stage of T cell functional maturation and negative selection to delete self- reactive clones by apoptosis. Accomplishment of this final differentiation pathway, a physiological T cell repertoire is formed: T cells acquire immunocompetence to respond to foreign antigens and tolerance to self- antigens, ready for the emigration to homing to the T cell regions of peripheral lymphoid organs and tissues. In this review, emphases are put on introducing the approaches applied in this area and our own observations. Basically, we have analyzed the late stage of medullary thymocyte phenotypic differentiation pathways of both CD4 SP and CD8 SP medullary thymocytes and the concomitant functional maturation pathway, in particular, of CD4 SP thymocytes. It is to provide a standard to compare the functional capacity of the cells at the developmental stages induced by different conditions. The cellular and molecular basis of this differentiation process has been partially described. Cellular & Molecular Immunology. 2004;1(1):3-11.

语种英语
WOS记录号WOS:000208922100002
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51196
Collection北京大学基础医学院_免疫学系
作者单位Peking Univ, Sch Basic Med Sci, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Chen, Weifeng. The Late Stage of T Cell Development within Mouse Thymus[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2004,1(1):3-11.
APA Chen, Weifeng.(2004).The Late Stage of T Cell Development within Mouse Thymus.CELLULAR & MOLECULAR IMMUNOLOGY,1(1),3-11.
MLA Chen, Weifeng."The Late Stage of T Cell Development within Mouse Thymus".CELLULAR & MOLECULAR IMMUNOLOGY 1.1(2004):3-11.
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