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学科主题: 公共卫生
题名:
Impaired development of mitochondria plays a role in the central nervous system defects of fetal alcohol syndrome
作者: Xu, YJ; Liu, P; Li, Y
关键词: alcohol ; central nervous system ; mitochondria development ; teratogenicity
刊名: BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
发表日期: 2005-02-01
DOI: 10.1002/bdra.20110
卷: 73, 期:2, 页:83-91
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Developmental Biology ; Toxicology
研究领域[WOS]: Developmental Biology ; Toxicology
关键词[WOS]: RAT-LIVER MITOCHONDRIA ; CHRONIC ETHANOL-CONSUMPTION ; FLOW-CYTOMETRY ; POSTNATAL-DEVELOPMENT ; ADENINE-NUCLEOTIDES ; NEURODEVELOPMENTAL DISORDER ; MORPHOMETRIC ANALYSIS ; PROTEIN-SYNTHESIS ; THYROID-HORMONES ; ATP SYNTHESIS
英文摘要:

BACKGROUND: Alcohol consumption during pregnancy can induce a wide spectrum of adverse effects in offspring. Microcephaly and mental retardation are two major defects of central nervous system (CNS). Most mechanism studies of alcohol-related CNS defects have been focused on the morphologically abnormal tissues, and more attention has been paid to nuclear alteration as opposed to organelle development. METHODS: A mouse model of fetal alcohol syndrome (FAS) was used to investigate the effect of alcohol on fetal cerebral mitochondria development. Pregnant mice were given different doses of ethanol intragastrically from GD6 to GD15. Fetal cerebral mitochondria were isolated and analyzed on GD18. RESULTS: Excessive cell apoptosis was found in the cerebra of prenatal alcohol exposure fetuses. Proliferation and differentiation of fetal cerebral mitochondria were inhibited by alcohol. Affected mitochondrial volume constriction and adenosine triphosphate (ATP) accumulation, reduced activities of respiratory chain complex I and IV and ATP synthase were detected in the cerebral tissue without obvious malformed appearance. CONCLUSIONS: Impaired mitochondria development plays a role in the CNS defects induced by prenatal alcohol exposure. Birth Defects Research (Part A) 73:83-91, 2005, (C) 2005 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000227252000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51200
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Lab Mol Toxicol & Dev Mol Biol, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China

Recommended Citation:
Xu, YJ,Liu, P,Li, Y. Impaired development of mitochondria plays a role in the central nervous system defects of fetal alcohol syndrome[J]. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY,2005,73(2):83-91.
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